CRIP2

Last updated
CRIP2
Protein CRIP2 PDB 2cu8.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CRIP2 , CRIP, CRP2, ESP1, cysteine rich protein 2
External IDs OMIM: 601183 HomoloGene: 135666 GeneCards: CRIP2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270837
NM_001270841
NM_001312

n/a

RefSeq (protein)

NP_001257766
NP_001257770
NP_001303

n/a

Location (UCSC) Chr 14: 105.47 – 105.48 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Cysteine-rich protein 2 is a protein that in humans is encoded by the CRIP2 gene. [3] [4] [5] [6]

Contents

CRIP2 and the closely related CRIP1 are cysteine-rich proteins containing two LIM domains. They are highly expressed during cardiovascular development and act to bridge serum response factor and GATA proteins and stimulate smooth muscle target genes. [7]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182809 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Tsui SK, Chan PP, Cheuk CW, Liew CC, Waye MM, Fung KP, Lee CY (Feb 1997). "A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation". Biochem Mol Biol Int. 39 (4): 747–54. doi: 10.1080/15216549600201831 . PMID   8843343. S2CID   25981657.
  4. Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (January 1996). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID   8824798.
  5. Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD (Mar 2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle". J Biol Chem. 275 (8): 5504–11. doi: 10.1074/jbc.275.8.5504 . PMID   10681529.
  6. "Entrez Gene: CRIP2 cysteine-rich protein 2".
  7. Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (January 2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors". Dev. Cell. 4 (1): 107–18. doi: 10.1016/S1534-5807(02)00396-9 . PMID   12530967.

Further reading