CST11

CST11
Identifiers
Aliases	CST11 , CST8L, CTES2, SC13, dJ322G13.6, cystatin 11
External IDs	OMIM: 609731 MGI: 1925490 HomoloGene: 15634 GeneCards: CST11
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p11.21 Start 23,450,403 bp [1] End 23,452,876 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 G3 Start 148,610,529 bp [2] End 148,613,417 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis stromal cell of endometrium fundus breast kidney sigmoid colon urinary bladder kidney myometrium Top expressed in morula white adipose tissue foregut gonad stomach testicle More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity protease binding cysteine-type endopeptidase inhibitor activity Cellular component sperm flagellum sperm head extracellular space extracellular region nucleus cytoplasm Biological process negative regulation of peptidase activity defense response to bacterium androgen receptor signaling pathway defense response to Gram-negative bacterium negative regulation of cysteine-type endopeptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140880 78240 Ensembl ENSG00000125831 ENSMUSG00000036958 UniProt Q9H112 Q9D269 RefSeq (mRNA) NM_130794 NM_080830 NM_030059 RefSeq (protein) NP_543020 NP_570612 NP_084335 Location (UCSC) Chr 20: 23.45 – 23.45 Mb Chr 2: 148.61 – 148.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cystatin-11 is a protein that in humans is encoded by the CST11 gene. ^[5]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity.

There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions.

The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein whose specific function has not been determined. Alternative splicing yields two variants encoding distinct isoforms. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000125831 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036958 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CST11 cystatin 11".

External links

• Human CST11 genome location and CST11 gene details page in the UCSC Genome Browser .

Further reading

• Brown WM, Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution". Protein Sci. 6 (1): 5–12. doi:10.1002/pro.5560060102. PMC   2143511 . PMID   9007972.
• Saitoh E, Isemura S, Sanada K, et al. (1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". Biol. Chem. Hoppe-Seyler. 369 Suppl: 191–7. PMID   3202964.
• Dickinson DP, Thiesse M, Dempsey LD, Millar SJ (1993). "Genomic cloning, physical mapping, and expression of human type 2 cystatin genes". Crit. Rev. Oral Biol. Med. 4 (3–4): 573–80. doi:10.1177/10454411930040034401. PMID   7690606.
• Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ (1995). "Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2". Genomics. 24 (1): 172–5. doi:10.1006/geno.1994.1595. PMID   7896273.
• Thiesse M, Millar SJ, Dickinson DP (1994). "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20". DNA Cell Biol. 13 (2): 97–116. doi:10.1089/dna.1994.13.97. PMID   8179826.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Hamil KG, Liu Q, Sivashanmugam P, et al. (2002). "Cystatin 11: a new member of the cystatin type 2 family". Endocrinology. 143 (7): 2787–96. doi: 10.1210/endo.143.7.8925 . PMID   12072414.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.