CST9L

CST9L
Identifiers
Aliases	CST9L , CTES7B, bA218C14.1, cystatin 9-like, cystatin 9 like
External IDs	OMIM: 616536; MGI: 1340053; HomoloGene: 49222; GeneCards: CST9L; OMA:CST9L - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p11.21 Start 23,564,732 bp [1] End 23,568,484 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 G3 Start 148,677,067 bp [2] End 148,680,658 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis corpus epididymis caput epididymis metanephros duodenum mammary gland female breast lactiferous gland Top expressed in seminiferous tubule Gonadal ridge spermatocyte spermatogonium spermatid epithelium of seminiferous tubule of testis Sertoli cell gastrula Ileal epithelium atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein binding protease binding cysteine-type endopeptidase inhibitor activity Cellular component extracellular region extracellular space Biological process negative regulation of peptidase activity negative regulation of cysteine-type endopeptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 128821 13013 Ensembl ENSG00000101435 ENSMUSG00000027445 UniProt Q9H4G1 Q9Z0H6 RefSeq (mRNA) NM_080610 NM_009979 RefSeq (protein) NP_542177 NP_034109 Location (UCSC) Chr 20: 23.56 – 23.57 Mb Chr 2: 148.68 – 148.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cystatin-9-like is a protein that in humans is encoded by the CST9L gene. ^[5]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to mouse cystatin 9. Based on its testis-specific expression, it is likely to have a role in tissue reorganization during early testis development. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000101435 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027445 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CST9L cystatin 9-like (mouse)".

Further reading

• Brown WM, Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution". Protein Sci. 6 (1): 5–12. doi:10.1002/pro.5560060102. PMC   2143511 . PMID   9007972.
• Saitoh E, Isemura S, Sanada K, et al. (1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". Biol. Chem. Hoppe-Seyler. 369 Suppl: 191–7. PMID   3202964.
• Dickinson DP, Thiesse M, Dempsey LD, Millar SJ (1993). "Genomic cloning, physical mapping, and expression of human type 2 cystatin genes". Crit. Rev. Oral Biol. Med. 4 (3–4): 573–80. doi:10.1177/10454411930040034401. PMID   7690606.
• Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ (1995). "Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2". Genomics. 24 (1): 172–5. doi:10.1006/geno.1994.1595. PMID   7896273.
• Thiesse M, Millar SJ, Dickinson DP (1994). "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20". DNA Cell Biol. 13 (2): 97–116. doi:10.1089/dna.1994.13.97. PMID   8179826.
• Eriksson A, Töhönen V, Wedell A, Nordqvist K (2002). "Isolation of the human testatin gene and analysis in patients with abnormal gonadal development". Mol. Hum. Reprod. 8 (1): 8–15. doi:10.1093/molehr/8.1.8. PMID   11756564.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• Human CST9L genome location and CST9L gene details page in the UCSC Genome Browser .