CUL2

CUL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WQO
Identifiers
Aliases	CUL2 , cullin 2
External IDs	OMIM: 603135; MGI: 1918995; HomoloGene: 2662; GeneCards: CUL2; OMA:CUL2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10p11.21 Start 35,008,504 bp [1] End 35,127,006 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 A1 Start 3,382,988 bp [2] End 3,436,377 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm muscle of thigh gastrocnemius muscle gonad Achilles tendon ventricular zone stromal cell of endometrium islet of Langerhans ganglionic eminence biceps brachii Top expressed in superior cervical ganglion epiblast abdominal wall facial motor nucleus arcuate nucleus ventromedial nucleus paraventricular nucleus of hypothalamus lateral hypothalamus sternocleidomastoid muscle neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase activity ubiquitin protein ligase binding protein-containing complex binding Cellular component cullin-RING ubiquitin ligase complex cytosol nucleolus VCB complex nucleoplasm Cul2-RING ubiquitin ligase complex SCF ubiquitin ligase complex Biological process intrinsic apoptotic signaling pathway viral process protein catabolic process regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of cell population proliferation ubiquitin-dependent protein catabolic process post-translational protein modification G1/S transition of mitotic cell cycle protein ubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8453 71745 Ensembl ENSG00000108094 ENSMUSG00000024231 UniProt Q13617 Q9D4H8 RefSeq (mRNA) NM_001198777 NM_001198778 NM_001198779 NM_003591 NM_001324375 NM_001324376 NM_029402 NM_001360829 RefSeq (protein) NP_001185706 NP_001185707 NP_001185708 NP_001311304 NP_001311305 NP_003582 NP_083678 NP_001347758 Location (UCSC) Chr 10: 35.01 – 35.13 Mb Chr 18: 3.38 – 3.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cullin-2 is a protein that in humans is encoded by the CUL2 gene. ^{[5] [6]}

Interactions

CUL2 has been shown to interact with:

• CAND1, ^{[7] [8]}
• DCUN1D1, ^[9]
• RBX1, ^{[10] [11]}
• SAP130, ^[7]
• TCEB2 ^{[7] [12]} and
• Von Hippel-Lindau tumor suppressor. ^{[7] [12] [13] [14] [15]}

References

1. GRCh38: Ensembl release 89: ENSG00000108094 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024231 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi: 10.1016/S0092-8674(00)81267-2 . PMID   8681378. S2CID   15805562.
6. "Entrez Gene: CUL2 cullin 2".
7. Menon S, Tsuge T, Dohmae N, Takio K, Wei N (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochem. 9: 1. doi: 10.1186/1471-2091-9-1 . PMC   2265268 . PMID   18173839.
8. Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". J. Biol. Chem. 278 (18): 15905–10. doi: 10.1074/jbc.M213070200 . PMID   12609982.
9. Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". J. Biol. Chem. 283 (48): 33211–20. doi: 10.1074/jbc.M804440200 . PMC   2586271 . PMID   18826954.
10. Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601–6. doi: 10.1073/pnas.252646399 . PMC   139190 . PMID   12481031.
11. Ohta T, Michel JJ, Schottelius AJ, Xiong Y (Apr 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi: 10.1016/s1097-2765(00)80482-7 . PMID   10230407. S2CID   19371828.
12. Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (Aug 2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi: 10.1074/jbc.M103093200 . PMID   11384984.
13. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
14. Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG (Dec 1999). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. Invest. 104 (11): 1583–91. doi:10.1172/JCI8161. PMC   481054 . PMID   10587522.
15. Hacker KE, Lee CM, Rathmell WK (2008). Zhang B (ed.). "VHL type 2B mutations retain VBC complex form and function". PLOS ONE. 3 (11): e3801. Bibcode:2008PLoSO...3.3801H. doi: 10.1371/journal.pone.0003801 . PMC   2583047 . PMID   19030229.

External links

• Human CUL2 genome location and CUL2 gene details page in the UCSC Genome Browser .

Further reading

• Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG (1995). "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C". Science. 269 (5229): 1444–6. Bibcode:1995Sci...269.1444K. doi:10.1126/science.7660130. PMID   7660130. S2CID   25410108.
• Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD (1997). "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2156–61. Bibcode:1997PNAS...94.2156P. doi: 10.1073/pnas.94.6.2156 . PMC   20057 . PMID   9122164.
• Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG (1998). "Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2". Mol. Cell. Biol. 18 (2): 732–41. doi:10.1128/mcb.18.2.732. PMC   108784 . PMID   9447969.
• Wada H, Yeh ET, Kamitani T (1999). "Identification of NEDD8-conjugation site in human cullin-2". Biochem. Biophys. Res. Commun. 257 (1): 100–5. doi:10.1006/bbrc.1999.0339. PMID   10092517.
• Ohta T, Michel JJ, Schottelius AJ, Xiong Y (1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi: 10.1016/S1097-2765(00)80482-7 . PMID   10230407. S2CID   19371828.
• Pause A, Peterson B, Schaffar G, Stearman R, Klausner RD (1999). "Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9533–8. Bibcode:1999PNAS...96.9533P. doi: 10.1073/pnas.96.17.9533 . PMC   22243 . PMID   10449727.
• Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A (1999). "Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12436–41. Bibcode:1999PNAS...9612436I. doi: 10.1073/pnas.96.22.12436 . PMC   22941 . PMID   10535940.
• Hori T, Osaka F, Chiba T, Miyamoto C, Okabayashi K, Shimbara N, Kato S, Tanaka K (2000). "Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene. 18 (48): 6829–34. doi: 10.1038/sj.onc.1203093 . PMID   10597293.
• Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW (2000). "Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10430–5. Bibcode:2000PNAS...9710430K. doi: 10.1073/pnas.190332597 . PMC   27041 . PMID   10973499.
• Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. Bibcode:2001Sci...292.1382L. doi:10.1126/science.1059780. PMID   11337588. S2CID   14224920.
• Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi: 10.1074/jbc.M103093200 . PMID   11384984.
• Ohh M, Kim WY, Moslehi JJ, Chen Y, Chau V, Read MA, Kaelin WG (2002). "An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells". EMBO Rep. 3 (2): 177–82. doi:10.1093/embo-reports/kvf028. PMC   1083969 . PMID   11818338.
• Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (2002). "Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling". Science. 296 (5574): 1886–9. Bibcode:2002Sci...296.1886M. doi: 10.1126/science.1073440 . PMID   12004076. S2CID   19641938.
• Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC (2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10353–8. Bibcode:2002PNAS...9910353B. doi: 10.1073/pnas.162424199 . PMC   124918 . PMID   12149480.
• Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". J. Biol. Chem. 278 (18): 15905–10. doi: 10.1074/jbc.M213070200 . PMID   12609982.
• Yan Q, Kamura T, Cai Y, Jin J, Ivan M, Mushegian A, Conaway RC, Conaway JW (2004). "Identification of Elongin C and Skp1 sequences that determine Cullin selection". J. Biol. Chem. 279 (41): 43019–26. doi: 10.1074/jbc.M408018200 . PMID   15280393.