CAND1

CAND1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1U6G, 4A0C
Identifiers
Aliases	CAND1 , TIP120, TIP120A, cullin associated and neddylation dissociated 1
External IDs	OMIM: 607727; MGI: 1261820; HomoloGene: 10202; GeneCards: CAND1; OMA:CAND1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q14.3-q15 Start 67,269,358 bp [1] End 67,319,953 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 D2|10 67.08 cM Start 119,035,160 bp [2] End 119,075,960 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence stromal cell of endometrium Achilles tendon islet of Langerhans endothelial cell appendix left ovary right ovary parietal pleura Top expressed in spermatocyte spermatid tail of embryo somite mandibular prominence maxillary prominence Gonadal ridge epiblast cumulus cell morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function TBP-class protein binding protein binding Cellular component cytoplasm cullin-RING ubiquitin ligase complex Golgi apparatus extracellular exosome membrane nucleus ubiquitin ligase complex extracellular region secretory granule lumen ficolin-1-rich granule lumen nucleoplasm cytosol Biological process positive regulation of transcription, DNA-templated SCF complex assembly cell differentiation positive regulation of RNA polymerase II transcription preinitiation complex assembly negative regulation of catalytic activity protein ubiquitination neutrophil degranulation cellular iron ion homeostasis post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55832 71902 Ensembl ENSG00000111530 ENSMUSG00000020114 UniProt Q86VP6 Q6ZQ38 RefSeq (mRNA) NM_001329674 NM_001329675 NM_001329676 NM_018448 NM_027994 RefSeq (protein) NP_001316603 NP_001316604 NP_001316605 NP_060918 NP_082270 Location (UCSC) Chr 12: 67.27 – 67.32 Mb Chr 10: 119.04 – 119.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene. ^{[5] [6] [7]}

Interactions

CAND1 has been shown to interact with:

• CUL1, ^{[8] [9]}
• CUL2, ^{[8] [9]}
• CUL3, ^[8]
• CUL4A, ^[8]
• CUL4B, ^[8]
• DCUN1D1, ^[10] and
• RBX1. ^{[8] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000111530 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020114 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
6. Yogosawa S, Makino Y, Yoshida T, Kishimoto T, Muramatsu M, Tamura T (Dec 1996). "Molecular cloning of a novel 120-kDa TBP-interacting protein". Biochemical and Biophysical Research Communications. 229 (2): 612–7. doi:10.1006/bbrc.1996.1852. PMID   8954946.
7. "Entrez Gene: CAND1 cullin-associated and neddylation-dissociated 1".
8. Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". The Journal of Biological Chemistry. 278 (18): 15905–10. doi: 10.1074/jbc.M213070200 . PMID   12609982.
9. Menon S, Tsuge T, Dohmae N, Takio K, Wei N (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochemistry. 9: 1. doi: 10.1186/1471-2091-9-1 . PMC   2265268 . PMID   18173839.
10. Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". The Journal of Biological Chemistry. 283 (48): 33211–20. doi: 10.1074/jbc.M804440200 . PMC   2586271 . PMID   18826954.

External links

• Human CAND1 genome location and CAND1 gene details page in the UCSC Genome Browser .

Further reading

• Yogosawa S, Kayukawa K, Kawata T, Makino Y, Inoue S, Okuda A, Muramatsu M, Tamura T (Dec 1999). "Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A". Biochemical and Biophysical Research Communications. 266 (1): 123–8. doi:10.1006/bbrc.1999.1773. PMID   10581176.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (Aug 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Liu J, Furukawa M, Matsumoto T, Xiong Y (Dec 2002). "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases". Molecular Cell. 10 (6): 1511–8. doi: 10.1016/S1097-2765(02)00783-9 . PMID   12504025. S2CID   28959307.
• Zheng J, Yang X, Harrell JM, Ryzhikov S, Shim EH, Lykke-Andersen K, Wei N, Sun H, Kobayashi R, Zhang H (Dec 2002). "CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex". Molecular Cell. 10 (6): 1519–26. doi: 10.1016/S1097-2765(02)00784-0 . PMID   12504026.
• Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". The Journal of Biological Chemistry. 278 (18): 15905–10. doi: 10.1074/jbc.M213070200 . PMID   12609982.
• Feng S, Shen Y, Sullivan JA, Rubio V, Xiong Y, Sun TP, Deng XW (Jul 2004). "Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation". The Plant Cell. 16 (7): 1870–82. doi:10.1105/tpc.021949. PMC   514167 . PMID   15208391.
• Goldenberg SJ, Cascio TC, Shumway SD, Garbutt KC, Liu J, Xiong Y, Zheng N (Nov 2004). "Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases". Cell. 119 (4): 517–28. doi: 10.1016/j.cell.2004.10.019 . PMID   15537541. S2CID   1606360.
• Min KW, Kwon MJ, Park HS, Park Y, Yoon SK, Yoon JB (Sep 2005). "CAND1 enhances deneddylation of CUL1 by COP9 signalosome". Biochemical and Biophysical Research Communications. 334 (3): 867–74. doi:10.1016/j.bbrc.2005.06.188. PMID   16036220.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.