DCUN1D1

DCUN1D1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TDU, 3TDZ, 4P5O
Identifiers
Aliases	DCUN1D1 , DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3, defective in cullin neddylation 1 domain containing 1
External IDs	OMIM: 605905; MGI: 2150386; HomoloGene: 10773; GeneCards: DCUN1D1; OMA:DCUN1D1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q26.33 Start 182,938,074 bp [1] End 182,985,953 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 B Start 35,946,254 bp [2] End 35,991,594 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm endothelial cell tendon of biceps brachii trabecular bone buccal mucosa cell Achilles tendon tail of epididymis middle temporal gyrus Top expressed in zygote spermatid Rostral migratory stream secondary oocyte genital tubercle spermatocyte interventricular septum Paneth cell triceps brachii muscle vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cullin family protein binding ubiquitin-like protein binding protein binding ubiquitin conjugating enzyme binding Cellular component ubiquitin ligase complex nucleus cytosol Biological process protein neddylation positive regulation of ubiquitin-protein transferase activity post-translational protein modification positive regulation of protein neddylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54165 114893 Ensembl ENSG00000043093 ENSMUSG00000027708 UniProt Q96GG9 Q9QZ73 RefSeq (mRNA) NM_001308101 NM_020640 NM_001205361 NM_001205362 NM_033623 RefSeq (protein) NP_001295030 NP_065691 NP_001192290 NP_001192291 NP_296372 Location (UCSC) Chr 3: 182.94 – 182.99 Mb Chr 3: 35.95 – 35.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DCN1-like protein 1 is a protein that in humans is encoded by the DCUN1D1 gene. ^{[5] [6] [7]}

DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells. ^{[8] [9] [10]}

Interactions

DCUN1D1 has been shown to interact with:

• CAND1, ^[11]
• CUL1, ^[11]
• CUL2, ^[11]
• CUL3 ^[11] and
• RBX1. ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000043093 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027708 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mas C, Bourgeois F, Bulfone A, Levacher B, Mugnier C, Simonneau M (Apr 2000). "Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16". Genomics. 65 (1): 70–4. doi:10.1006/geno.2000.6126. PMID   10777668.
6. Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M (Jun 2005). "The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae". Nature. 435 (7046): 1257–61. Bibcode:2005Natur.435.1257K. doi:10.1038/nature03662. PMID   15988528. S2CID   4328225.
7. "Entrez Gene: DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)".
8. Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B (Jun 2010). "SCCRO promotes glioma formation and malignant progression in mice". Neoplasia. 12 (6): 476–84. doi:10.1593/neo.10202. PMC   2887088 . PMID   20563250.
9. Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B (Oct 2006). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas". Cancer Research. 66 (19): 9437–44. doi: 10.1158/0008-5472.CAN-06-2074 . PMID   17018598.
10. Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, Kouros-Mehr H (2014). "Identification of druggable cancer driver genes amplified across TCGA datasets". PLOS ONE. 9 (5): e98293. Bibcode:2014PLoSO...998293C. doi: 10.1371/journal.pone.0098293 . PMC   4038530 . PMID   24874471.
11. Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". The Journal of Biological Chemistry. 283 (48): 33211–20. doi: 10.1074/jbc.M804440200 . PMC   2586271 . PMID   18826954.

Further reading

• Sarkaria IS, Pham D, Ghossein RA, Talbot SG, Hezel M, Dudas ME, Ebright MI, Chuai S, Memoli N, Venkatraman ES, Miller VA, Kris MG, Zakowski MF, Rusch VW, Singh B (Nov 2004). "SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma". The Annals of Thoracic Surgery. 78 (5): 1734–41. doi: 10.1016/j.athoracsur.2004.05.056 . PMID   15511464.
• Estilo CL, O-Charoenrat P, Ngai I, Patel SG, Reddy PG, Dao S, Shaha AR, Kraus DH, Boyle JO, Wong RJ, Pfister DG, Huryn JM, Zlotolow IM, Shah JP, Singh B (Jun 2003). "The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue". Clinical Cancer Research. 9 (6): 2300–6. PMID   12796399.
• Talbot SG, O-charoenrat P, Sarkaria IS, Ghossein R, Reddy P, Ngai I, Cordeiro CN, Wong RJ, Kris MG, Rusch VW, Singh B (May 2004). "Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A". Annals of Surgical Oncology. 11 (5): 530–4. doi:10.1245/ASO.2004.03.014. PMID   15123463. S2CID   7962781.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Jacques C, Baris O, Prunier-Mirebeau D, Savagner F, Rodien P, Rohmer V, Franc B, Guyetant S, Malthiery Y, Reynier P (Apr 2005). "Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors". The Journal of Clinical Endocrinology and Metabolism. 90 (4): 2314–20. doi:10.1210/jc.2004-1337. PMID   15623817. S2CID   7907994.
• Sarkaria IS, Stojadinovic A, Talbot SG, Hoos A, Dudas ME, Brennan MF, Ghossein RA, Singh B (Dec 2004). "Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas". Surgery. 136 (6): 1122–8. doi:10.1016/j.surg.2004.06.041. PMID   15657565.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B (Oct 2006). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas". Cancer Research. 66 (19): 9437–44. doi: 10.1158/0008-5472.CAN-06-2074 . PMID   17018598.