| DCUN1D1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | DCUN1D1 , DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3, defective in cullin neddylation 1 domain containing 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605905 MGI: 2150386 HomoloGene: 10773 GeneCards: DCUN1D1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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DCN1-like protein 1 is a protein that in humans is encoded by the DCUN1D1 gene. [5] [6] [7]
DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells. [8] [9] [10]
DCUN1D1 has been shown to interact with:
Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene.
p16, is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene. A deletion in this gene can result in insufficient or non-functional p16, accelerating the cell cycle and resulting in many types of cancer.
Receptor tyrosine-protein kinase erbB-3, also known as HER3, is a membrane bound protein that in humans is encoded by the ERBB3 gene.
Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 gene.
AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the AKT2 gene. It influences metabolite storage as part of the insulin signal transduction pathway.
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.
ERG is an oncogene. ERG is a member of the ETS family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.
Serpin B3 is a protein that in humans is encoded by the SERPINB3 gene.
Podoplanin is a protein that in humans is encoded by the PDPN gene.
Serpin B4 is a protein that in humans is encoded by the SERPINB4 gene.
Cullin 3 is a protein that in humans is encoded by the CUL3 gene.
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.
Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene.
Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217 gene.
Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene.
Breast carcinoma-amplified sequence 1 is a protein that in humans is encoded by the BCAS1 gene.
Metadherin, also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene.
Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene.
CKLF-like MARVEL transmembrane domain-containing protein 3, also termed chemokine-like factor superfamily 3, is a member of the CKLF-like MARVEL transmembrane domain-containing family of proteins. In humans, CMTM2 protein is encoded by the CMTM3 gene located in band 22.1 on the long arm of chromosome 16. This protein is expressed in a wide range of tissues, including fetal tissues. It is highly expressed in the male reproductive system, particularly testicular tissues and may play a role in the development of this tissue. It is also highly expressed in the immune system including circulating blood cells, i.e. B lymphocytes, CD4+ T lymphocytes, and monocytes. However, CMTM3 protein is weakly expressed or unexpressed in the malignant tissues of several types of cancers. In many but not all of theses cancers, this decreased or lack of expression appears due to methylation of the GpC islands in the promoter region, and thereby the silencing, of the CMTM3 gene.
MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.
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