Calvin Ralph Stiller (born February 12, 1941) [1] is a Canadian physician, scientist, and entrepreneur. He retired as a member of the Schulich School of Medicine & Dentistry at Western University in London, Ontario. [2]
Stiller is from Naicam, Saskatchewan. [3] He was born to Mildred Stiller (née Parsons) and the Reverend Hilmer Stiller, a minister ordained by the Pentecostal Assemblies of Canada. [4] Stiller spent his childhood and adolescence in Naicam, Tisdale, and Saskatoon. [5] Stiller graduated from Bedford Road Collegiate and completed two years of undergraduate pre-medical studies in Arts and Science at the University of Saskatchewan. He graduated with an MD from the University of Saskatchewan in 1965. [6]
Stiller completed his post-graduate fellowship studies at the University of Western Ontario in London, Ontario and the University of Alberta in Edmonton. [7] Stiller developed a specialization in nephrology, as well as in the related areas of transplantation, immunology, and infection. In 1972, he received his fellowship designation of FRCP(C) in the Royal College of Physicians and Surgeons of Canada. [8] He co-founded the Robarts Research Institute in 1986. [9]
Stiller was an early adopter of computerized patient records; he was a partner in the firm that co-created the first form of telemedicine offered by the Government of Ontario. The eventual widespread success of organ transplantation led to Stiller’s establishing the Multi-Organ Transplant Service and the Canadian Centre for Transplantation in London, over which he acted as chief from 1984 until 1996. [10] Stiller was principal investigator in the early 1980s in the clinical trials and market development of the drug cyclosporine for use as a first-line therapy for transplant rejection. [11] He and his brother, the Reverend Brian Stiller, co-authored Lifegifts: The Real Story of Organ Transplants, an account of the history of human organ transplants. [12] Stiller was on a team of researchers that proved that human type 1 diabetes is an autoimmune disorder and therefore amenable to immunosuppressant treatment. [13]
Stiller co-founded the Canadian Medical Discoveries Fund Inc., which has raised and managed over half a billion dollars in assets. [14] Stiller served as founder and chair of the Ontario Institute for Cancer Research, as well as the chair of Genome Canada. [15] Along with Dr. John Evans, a former president of the University of Toronto, and Ken Knox, Stiller catalyzed the 2000 launch of the Medical and Related Science (MaRS) Discovery District in downtown Toronto, and then served as its director. [16] Stiller was invited by the then Premier of Ontario, Mike Harris, to chair the Ontario Research and Development Challenge Fund, which, together with the Ontario Innovation Trust, would provide over $1.2-billion in R&D support during the following decade to Ontario universities in an alliance with research-intensive businesses. [17]
Stiller was named Ontario Entrepreneur of the Year in 1996. [18] In 2000, Western University established the Novartis-Calvin Stiller Chair in Xenotransplantation. [19] That year, he was made a Member of the Order of Ontario. [20] In 2002, the namesake Stiller Centre for Technology Commercialization was opened in London. [21] He was recognized by his alma mater, the University of Saskatchewan, in its "100 Graduates of Influence", an all-time list celebrated to mark the university's centenary in 2007. [22] In 2012, he was invested as an Officer of the Order of Canada, having been invested as a Member in 1995. [23]
In 2010, Stiller was inducted into the Canadian Medical Hall of Fame. [1] Also in 2010, he was made a Distinguished Fellow of the Canadian Academy of Health Sciences, [24] and won the highly prestigious Canada Gairdner Wightman Award. [25]
Xenotransplantation, or heterologous transplant, is the transplantation of living cells, tissues or organs from one species to another. Such cells, tissues or organs are called xenografts or xenotransplants. It is contrasted with allotransplantation, syngeneic transplantation or isotransplantation and autotransplantation. Xenotransplantation is an artificial method of creating an animal-human chimera, that is, a human with a subset of animal cells. In contrast, an individual where each cell contains genetic material from a human and an animal is called a human–animal hybrid.
The Temerty Faculty of Medicine is the medical school of the University of Toronto. Founded in 1843, the faculty is based in Downtown Toronto and is one of Canada's oldest institutions of medical studies, being known for the discovery of insulin, stem cells and the site of the first single and double lung transplants in the world.
Phil Gold is a Canadian physician, scientist, professor and author.
The Toronto General Hospital (TGH) is a major teaching hospital in Toronto, Ontario, Canada and the flagship campus of University Health Network (UHN). It is located in the Discovery District of Downtown Toronto along University Avenue's Hospital Row; it is directly north of The Hospital for Sick Children, across Gerrard Street West, and east of Princess Margaret Cancer Centre and Mount Sinai Hospital. The hospital serves as a teaching hospital for the University of Toronto Faculty of Medicine. In 2019, the hospital was ranked first for research in Canada by Research Infosource for the ninth consecutive year.
John Robert Evans was a Canadian cardiologist, academic, businessperson, and civic leader.
The Gairdner Foundation is a non-profit organization devoted to the recognition of outstanding achievements in biomedical research worldwide. It was created in 1957 by James Arthur Gairdner to recognize and reward the achievements of medical researchers whose work contributes significantly to improving the quality of human life. Since the first awards were made in 1959, the Gairdner Awards have become Canada's most prestigious medical awards, recognizing and celebrating the research of the world’s best and brightest biomedical researchers. Since 1959, more than 390 Canada Gairdner Awards have been given to scientists from 35 countries; of these recipients, 98 have subsequently gone on to win a Nobel Prize.
Joseph Louis Rotman,, was a noted Canadian businessman and philanthropist. Rotman was the founder, benefactor and member of many successful organizations, such as the Clairvest Group Inc., the Rotman Research Institute, the Rotman School of Management, and the Rotman Institute of Philosophy. Throughout his life, he received three honorary degrees, as well as an induction into the Canadian Business Hall of Fame. He is well-regarded for donating his time and financial assistance to numerous philanthropic causes including the arts, education and healthcare.
James Edgar Till is a University of Toronto biophysicist, best known for demonstrating – with Ernest McCulloch – the existence of stem cells.
Ernest Armstrong McCulloch was a University of Toronto cellular biologist, best known for demonstrating – with James Till – the existence of stem cells.
Robert Laing Noble was a Canadian physician who was involved in the discovery of vinblastine.
Murray Llewellyn Barr was a Canadian physician and medical researcher who discovered with graduate student Ewart George Bertram, in 1948, an important cell structure, the "Barr body".
The Schulich School of Medicine and Dentistry is the combined medical school and dental school of the University of Western Ontario, a public university in London, Ontario, Canada
MaRS Discovery District is a not-for-profit corporation founded in Toronto, Ontario, Canada in 2000. Its stated goal is to commercialize publicly funded medical research and other technologies with the help of local private enterprises and as such is a public-private partnership. As part of its mission MaRS says, "MaRS helps create successful global businesses from Canada's science, technology and social innovation." As of 2014, startup companies emerging from MaRS had created more than 4,000 jobs, and in the period of 2011 to 2014 had raised over $750 million in capital investments.
Mark Adam Hardy was Auchincloss Professor of Surgery, Director Emeritus of the Transplant Centre, and Vice Chairman and Residency Program Director of the Department of Surgery at the Columbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital in New York City. He retired from Columbia in 2023, after almost 50 years of service.
Alan Bernstein is Professor Emeritus at the University of Toronto and President Emeritus of the Canadian Institute for Advanced Research (CIFAR), where he served as President and CEO from 2012 to 2022. A Distinguished Fellow at the Munk School of Global Affairs and Public Policy, he is also a Fellow and Member of the Standing Committee for Science Planning at the International Science Council (2022-2025). Canadian Bernstein is recognized as a leader in health research, science policy, mentorship and organizational leadership.
Till & McCulloch are James Till and Ernest McCulloch who, while studying the effect of radiation on the bone marrow of mice at the Ontario Cancer Institute, in Toronto, demonstrated the existence of multipotent stem cells in 1961.
John Herbert Dirks is a Canadian physician.
David Lorne John Tyrrell is a Canadian physician.
Bernard Langer was a Canadian surgeon and educator. In 2015, he was inducted into the Canadian Medical Hall of Fame.
Jean-François Borel is a Belgian microbiologist and immunologist who is considered one of the discoverers of cyclosporin.