Ronald G. Worton OC FRSC (born April 2, 1942) is a Canadian doctor. [1]
Born in Winnipeg, Manitoba, he earned a BSc and MSc from the University of Manitoba and a PhD in medical biophysics from the University of Toronto. Worton pursued post-doctoral studies at Yale University. In 1971, he became director of the diagnostic cytogenetics laboratory at The Hospital for Sick Children in Toronto. Worton became geneticist in chief at the hospital and professor of Medical Genetics at the University of Toronto in 1985. In 1996, he became director of research at the Ottawa General Hospital and chief executive officer of the Ottawa Hospital Research Institute, as well as professor of medicine, University of Ottawa. [2]
Worton and his team identified the dystrophin gene whose mutation is associated with Duchenne and Becker muscular dystrophies. Under his leadership, the genetics department at The Hospital for Sick Children also identified genes associated with cystic fibrosis, Fanconi anemia, Wilson's disease, Wilms' tumor [2] and Tay–Sachs disease. [1]
Worton served four years on the board of the Human Genome Organization, twelve years as associate director for the Canadian Genetic Diseases network, six years as head of the Canadian Genome Analysis and Technology Program and four years as founding scientific director of the Canadian Stem Cell Network. [3]
He was awarded a Gairdner Foundation International Award in 1989, [4] was named an officer of the Order of Canada in 2012 [5] and is a fellow of the Royal Society of Canada. [3] He has also received the E. Mead Johnson Award for pediatrics research. [2] In 2014, Worton was inducted into the Canadian Medical Hall of Fame. [1]
Worton has retired from medical research and lives in Oakville, Ontario, spending his winters in Mesa, Arizona. [6]
Michael Smith was a British-born Canadian biochemist and businessman. He shared the 1993 Nobel Prize in Chemistry with Kary Mullis for his work in developing site-directed mutagenesis. Following a PhD in 1956 from the University of Manchester, he undertook postdoctoral research with Har Gobind Khorana at the British Columbia Research Council in Vancouver, British Columbia, Canada. Subsequently, Smith worked at the Fisheries Research Board of Canada Laboratory in Vancouver before being appointed a professor of biochemistry in the UBC Faculty of Medicine in 1966. Smith's career included roles as the founding director of the UBC Biotechnology Laboratory and the founding scientific leader of the Protein Engineering Network of Centres of Excellence (PENCE). In 1996 he was named Peter Wall Distinguished Professor of Biotechnology. Subsequently, he became the founding director of the Genome Sequencing Centre at the BC Cancer Research Centre.
Lap-Chee Tsui is a Chinese-born Canadian geneticist and served as the 14th Vice-Chancellor and President of the University of Hong Kong.
Marco A. Marra is a Distinguished Scientist and Director of Canada's Michael Smith Genome Sciences Centre at the BC Cancer Research Centre and Professor of Medical Genetics at the University of British Columbia (UBC). He also serves as UBC Canada Research Chair in Genome Science for the Canadian Institutes of Health Research and is an inductee in the Canadian Medical Hall of Fame. Marra has been instrumental in bringing genome science to Canada by demonstrating the pivotal role that genomics can play in human health and disease research.
Irene Ayako Uchida, was a Canadian scientist and Down syndrome researcher.
The Temerty Faculty of Medicine is the medical school of the University of Toronto. Founded in 1843, the faculty is based in Downtown Toronto and is one of Canada's oldest institutions of medical studies, being known for the discovery of insulin, stem cells and the site of the first single and double lung transplants in the world.
Charles Robert Scriver was a Canadian pediatrician and biochemical geneticist. His work focused on inborn errors of metabolism and led in establishing a Canada-wide newborn metabolic screening program.
Louis Siminovitch was a Canadian molecular biologist. He was a pioneer in human genetics, researcher into the genetic basis of muscular dystrophy and cystic fibrosis, and helped establish Ontario programs exploring genetic roots of cancer.
Oliver Smithies was a British-American geneticist and physical biochemist. He is known for introducing starch as a medium for gel electrophoresis in 1955, and for the discovery, simultaneously with Mario Capecchi and Martin Evans, of the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previously used, and the technique behind gene targeting and knockout mice. He received the Nobel Prize in Physiology or Medicine in 2007 for his genetics work.
Connie Jean Eaves, CorrFRSE, is a Canadian biologist with significant contributions to cancer and stem cell research. Eaves is a professor generics of genetics at the University of British Columbia and is also the co-founder with Allen C Eaves of Terry Fox Laboratory.
The Centre for Applied Genomics is a genome centre in the Research Institute of The Hospital for Sick Children, and is affiliated with the University of Toronto. TCAG also operates as a Science and Technology Innovation Centre of Genome Canada, with an emphasis on next-generation sequencing (NGS) and bioinformatics support. Research at TCAG focuses on the genetic and genomic basis of human variability, health and disease, including research on the genetics of autism spectrum disorder and structural variation of the human genome. The centre is located in the Peter Gilgan Centre for Research and Learning in downtown Toronto, Canada.
Janet Rossant, is a developmental biologist well known for her contributions to the understanding of the role of genes in embryo development. She is a world renowned leader in developmental biology. Her current research interests focus on stem cells, molecular genetics, and developmental biology. Specifically, she uses cellular and genetic manipulation techniques to study how genes control both normal and abnormal development of early mouse embryos. Rossant has discovered information on embryo development, how multiple types of stem cells are established, and the mechanisms by which genes control development. In 1998, her work helped lead to the discovery of the trophoblast stem cell, which has assisted in showing how congenital anomalies in the heart, blood vessels, and placenta can occur.
Stephen Wayne "Steve" Scherer is a Canadian scientist who studies genetic variation in human disease. He obtained his PhD at the University of Toronto under Professor Lap-chee Tsui. Together they founded Canada's first human genome centre, the Centre for Applied Genomics (TCAG) at the Hospital for Sick Children. He continues to serve as director of TCAG, and is also a University Professor in the Department of Molecular Genetics, and the director of the McLaughlin Centre at the Temerty Faculty of Medicine at the University of Toronto.
Alan Bernstein is Professor Emeritus at the University of Toronto and President Emeritus of CIFAR, where he served as President and CEO from 2012 to 2022. A Distinguished Fellow at the Munk School of Global Affairs and Public Policy, he is also a Fellow and Member of the Standing Committee for Science Planning at the International Science Council (2022-2025). Bernstein is recognized as a leader in health research, science policy, mentorship and organizational leadership.
Michael R. Hayden, is a Killam Professor of Medical Genetics at the University of British Columbia, the highest honour UBC can confer on any faculty member. Only four such awards have ever been conferred in the Faculty of Medicine. Dr. Hayden is also Canada Research Chair in Human Genetics and Molecular Medicine. Hayden is best known for his research in Huntington disease (HD).
Allan R. Ronald is a Canadian doctor and microbiologist. He has been instrumental in the investigation into sexually transmitted infections in Africa, particularly in the fields of HIV/AIDS. Ronald is the recipient of multiple awards and honours.
Antoine M. Hakim is a Canadian engineer and physician.
Francis Allan Plummer was a Canadian scientist, academic and HIV/AIDS researcher. He was "a recognized specialist in infectious diseases whose work influenced public health policy in Canada and abroad". He was Distinguished Professor Emeritus of Medicine and Medical Microbiology at the University of Manitoba and Scientific Director General, National Microbiology Laboratory.
Johanna Rommens is a Canadian geneticist who was on the research team which identified and cloned the CFTR gene, which when mutated, is responsible for causing cystic fibrosis (CF). She later discovered the gene responsible for Shwachman-Diamond syndrome, a rare genetic disorder that causes pancreatic and hematologic problems. She is a Senior Scientist Emeritus at SickKids Research Institute and a professor in the Department of Molecular Genetics at the University of Toronto.
Grant Robert Sutherland is a retired Australian human geneticist and celebrated cytogeneticist. He was the Director, Department of Cytogenetics and Molecular Genetics, Adelaide Women's and Children's Hospital for 27 years (1975-2002), then became the Foundation Research Fellow there until 2007. He is an Emeritus Professor in the Departments of Paediatrics and Genetics at the University of Adelaide.
Monica J. Justice is an American–Canadian developmental geneticist. She is the Canada Research Chair in Mammalian Molecular Genetics at the University of Toronto and Program Head of Genetics and Genome Biology at SickKids Hospital.