 | |
| Discipline | Oncology |
|---|---|
| Language | English |
| Edited by | M. Schwab |
| Publication details | |
| History | 1975-present |
| Publisher | |
| Frequency | 28/year |
| 9.756 (2021) | |
| Standard abbreviations | |
| ISO 4 | Cancer Lett. |
| Indexing | |
| CODEN | CALEDQ |
| ISSN | 0304-3835 (print) 1872-7980 (web) |
| LCCN | 77640685 |
| OCLC no. | 1874893 |
| Links | |
Cancer Letters is a peer-reviewed medical journal established in 1975 that focuses on the rapid publication of original research on multidisciplinary aspects of cancer. The editor-in-chief is M. Schwab.
Cancer Letters is abstracted and indexed in BIOSIS, Chemical Abstracts, Current Contents/Life Sciences, EMBASE, MEDLINE, Oncology Information Service, PASCAL and FRANCIS, and Scopus.
A Bayer designation is a stellar designation in which a specific star is identified by a Greek or Latin letter followed by the genitive form of its parent constellation's Latin name. The original list of Bayer designations contained 1,564 stars. The brighter stars were assigned their first systematic names by the German astronomer Johann Bayer in 1603, in his star atlas Uranometria. Bayer catalogued only a few stars too far south to be seen from Germany, but later astronomers supplemented Bayer's catalog with entries for southern constellations.
Heme, or haem, is a precursor to hemoglobin, which is necessary to bind oxygen in the bloodstream. Heme is biosynthesized in both the bone marrow and the liver.
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans.
Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum. Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, and fatigue. Most colorectal cancers are due to old age and lifestyle factors, with only a small number of cases due to underlying genetic disorders. Risk factors include diet, obesity, smoking, and lack of physical activity. Dietary factors that increase the risk include red meat, processed meat, and alcohol. Another risk factor is inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases. It typically starts as a benign tumor, often in the form of a polyp, which over time becomes cancerous.
Patrick Wayne Swayze was an American actor, dancer, and singer-songwriter known for playing distinctive lead roles, particularly romantic, tough, and comedic characters. He was also known for his media image and looks; People magazine named Swayze the "Sexiest Man Alive" in 1991.
Malignancy is the tendency of a medical condition to become progressively worse.
Frank Eugene "Hill" Harper is an American actor and author. He is known for his roles as Dr. Sheldon Hawkes in CSI: NY, Agent Spelman Boyle in Limitless and Dr. Marcus Andrews in The Good Doctor.
In the field of machine learning and specifically the problem of statistical classification, a confusion matrix, also known as error matrix, is a specific table layout that allows visualization of the performance of an algorithm, typically a supervised learning one; in unsupervised learning it is usually called a matching matrix.
Bessie Lillian Carter was an American nurse. Carter's son Jimmy Carter served as president of the United States from 1977 to 1981. She was also known for her contributions as a Peace Corps volunteer in India and for writing two books during his presidency.
Zbtb7, whose protein product is also known as Pokemon, is a gene that functions as a regulator of cellular growth and a proto oncogene.
Vindesine, also termed Eldisine, is a semisynthetic vinca alkaloid derived from the flowering plant Catharanthus roseus. Like the natural and semisynthetic vinca alkaloids derived from this plant, vindesine is an inhibitor of mitosis that is used as a chemotherapy drug. By inhibiting mitosis, vinedsine blocks the proliferation of cells, particularly the rapidly proliferation cells of certain types of cancer. It is used, generally in combination with other chemotherapeutic drugs, in the treatment of various malignancies such as leukaemia, lymphoma, melanoma, breast cancer, and lung cancer.
TOX high mobility group box family member 3, also known as TOX3, is a human gene.
Regorafenib, sold under the brand name Stivarga among others, is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Since 2009 it was studied as a potential treatment option in multiple tumor types. By 2015 it had two US approvals for advanced cancers.
Letters to God is a 2010 American Christian drama film directed by David Nixon and starring Robyn Lively, Jeffrey Johnson, Tanner Maguire, Michael Bolten and Bailee Madison. The story was written by Patrick Doughtie about his son Tyler, with the screenplay penned by Doughtie, Art D'Alessandro, Sandra Thrift and Cullen Douglas. The story took place in Nashville, Tennessee, but the movie was filmed in the Orlando, Florida area.
Black salve, also known by the brand name Cansema, is a pseudoscientific alternative cancer treatment. The product is commonly classified as an escharotic—a topical paste which destroys skin tissue and leaves behind a scar called an eschar. Escharotics were widely used to treat skin lesions in the early 1900s, but have since been replaced by safer and more effective treatments. Escharotics, such as black salves, are currently advertised by some alternative medicine marketers as treatments for skin cancer, often with unsubstantiated testimonials and unsupported claims of effectiveness.
RAD140 is an investigational selective androgen receptor modulator (SARM) that is developed by Radius Health, Inc. for use in androgen replacement therapy. It was licensed to Ellipses Pharmaceuticals in 2020. Some of the potential benefits under investigation are for the treatment of conditions such as muscle wasting and bone loss.
Epacadostat is an investigational drug for cancer. Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1). Epacadostat inhibits IDO1 by competitively blocking it, without interfering with IDO2 or tryptophan 2,3-dioxygenase (TDO). It has antitumor activity in some models, though is most effective when combined with other immunotherapy agents.
Brilanestrant (INN) is a nonsteroidal combined selective estrogen receptor modulator (SERM) and selective estrogen receptor degrader (SERD) that was discovered by Aragon Pharmaceuticals and was under development by Genentech for the treatment of locally advanced or metastatic estrogen receptor (ER)-positive breast cancer.
ERX-11, also known as ERα coregulator-binding modulator-11, is a novel antiestrogen and experimental hormonal antineoplastic agent which is being researched for the potential treatment of estrogen receptor-positive breast cancer. It is not a competitive antagonist of the estrogen receptor (ER) like conventional antiestrogens such as tamoxifen or fulvestrant; instead of binding to the ligand-binding site of the ER, ERX-11 interacts with a different part of the ERα and blocks protein–protein interactions of the ERα with coregulators that are necessary for the receptor to act and regulate gene expression. It was designed to bind to the coregulator binding region of the ERα and inhibit the ERα/coactivator interaction, although its precise binding site and mode of action have yet to be fully elucidated and understood. Nonetheless, it is clear that ERX-11 binds within the AF-2 domain of the ERα.
