Animal testing, also known as animal experimentation, animal research, and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study. This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. Experimental research with animals is usually conducted in universities, medical schools, pharmaceutical companies, defense establishments, and commercial facilities that provide animal-testing services to the industry. The focus of animal testing varies on a continuum from pure research, focusing on developing fundamental knowledge of an organism, to applied research, which may focus on answering some questions of great practical importance, such as finding a cure for a disease. Examples of applied research include testing disease treatments, breeding, defense research, and toxicology, including cosmetics testing. In education, animal testing is sometimes a component of biology or psychology courses. The practice is regulated to varying degrees in different countries.
The Draize test is an acute toxicity test devised in 1944 by Food and Drug Administration (FDA) toxicologists John H. Draize and Jacob M. Spines. Initially used for testing cosmetics, the procedure involves applying 0.5 mL or 0.5 g of a test substance to the eye or skin of a restrained, conscious animal, and then leaving it for set amount of time before rinsing it out and recording its effects. The animals are observed for up to 14 days for signs of erythema and edema in the skin test, and redness, swelling, discharge, ulceration, hemorrhaging, cloudiness, or blindness in the tested eye. The test subject is commonly an albino rabbit, though other species are used too, including dogs. The animals are euthanized after testing if the test renders irreversible damage to the eye or skin. Animals may be re-used for testing purposes if the product tested causes no permanent damage. Animals are typically reused after a "wash out" period during which all traces of the tested product are allowed to disperse from the test site.
In the animal rights movement, cruelty-free is a label for products or activities that do not harm or kill animals anywhere in the world. Products tested on animals or made from animals are not considered cruelty-free, since these tests are often painful and cause the suffering and death of millions of animals every year.
The United States National Agricultural Library (NAL) is one of the world's largest agricultural research libraries, and serves as a national library of the United States and as the library of the United States Department of Agriculture. Located in Beltsville, Maryland, it is one of five national libraries of the United States. It is also the coordinator for the Agriculture Network Information Center (AgNIC), a national network of state land-grant institutions and coordinator for the U.S. Department of Agriculture (USDA) field libraries.
The Animal Welfare Act was signed into law by President Lyndon B. Johnson on August 24, 1966. It is the main federal law in the United States that regulates the treatment of animals in research and exhibition. Other laws, policies, and guidelines may include additional species coverage or specifications for animal care and use, but all refer to the Animal Welfare Act as the minimally acceptable standard for animal treatment and care. The USDA and APHIS oversee the AWA and the House and Senate Agriculture Committees have primary legislative jurisdiction over the Act. Animals covered under this Act include any live or dead cat, dog, hamster, rabbit, nonhuman primate, guinea pig, and any other warm-blooded animal determined by the Secretary of Agriculture for research, pet use or exhibition. Excluded from the Act are birds, rats of the genus Rattus, mice of the genus Mus, farm animals, and all cold-blooded animals.
Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals.
Michael Balls is a British zoologist and professor emeritus of medical cell biology at the University of Nottingham. He is best known for his work on laboratory animal welfare and alternatives to animal testing.
Animal testing regulations are guidelines that permit and control the use of non-human animals for scientific experimentation. They vary greatly around the world, but most governments aim to control the number of times individual animals may be used; the overall numbers used; and the degree of pain that may be inflicted without anesthetic.
Fund for the Replacement of Animals in Medical Experiments (FRAME) is a charity based in Nottingham, UK. FRAME funds and promotes alternatives to animal testing.
The European Partnership for Alternative Approaches to Animal Testing (EPAA) promotes the application of the 3Rs principles in meeting regulatory requirements for products such as pharmaceuticals, chemicals, soaps, detergents and cosmetics. The EPAA covers research and development, as well as the use of 3Rs approaches in regulatory compliance and communication and dissemination.
The New England Anti-Vivisection Society (NEAVS) is a national, registered 501(c)(3) nonprofit organization "dedicated to ending the use of animals in research, testing, and science education" and replacing them with "modern alternatives that are ethically, humanely, and scientifically superior."
The Three Rs (3Rs) are guiding principles for more ethical use of animals in product testing and scientific research. They were first described by W. M. S. Russell and R. L. Burch in 1959. The 3Rs are:
- Replacement:methods which avoid or replace the use of animals in research
- Reduction: use of methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain more information from the same number of animals.
- Refinement: use of methods that alleviate or minimize potential pain, suffering or distress, and enhance animal welfare for the animals used.
The Universities Federation for Animal Welfare (UFAW) is an animal welfare science society. It is a UK-registered scientific and educational charity.
Animal welfare and rights in the People's Republic of China is a topic of growing interest. China has had limited animal protections by international standards, and animal-rights activists have condemned the treatment of animals in the country. Movements towards animal welfare and animal rights are expanding in China, including among homegrown Chinese activists, but face resistance from nationalists.
A Designated Member Review (DMR) or Designated Subcommittee Review (DSR), also known as Designated Review, is a review of a protocol where a committee designates one or more members of the committee to review a decisionmaking process or a protocol or procedure, a review which would ordinarily require the full committee's review. Typically this pertains to IACUCs.
The Institute for Laboratory Animal Research (ILAR) is a United States organization which develops and shares information and guidelines about animal testing and care of laboratory animals. It is a unit in the United States National Research Council. Their mission is "to evaluate and to report on scientific, technological, and ethical use of animals and related biological resources, and of non-animal alternatives in non-food settings, such as research, testing, education, and production of pharmaceuticals".
Animal welfare in the United States relates to the treatment of non-human animals in fields such as agriculture, hunting, medical testing and the domestic ownership of animals. It is distinct from animal conservation.
Directive 2010/63/EU is the European Union (EU) legislation "on the protection of animals used for scientific purposes" and is one of the most stringent ethical and welfare standards worldwide.
William Moy Stratton Russell, also known as Bill Russell, was a British zoologist and animal welfare worker. He was best known for writing, along with R. L. Burch (1926-1996) The Principles of Humane Experimental Technique (1959), a landmark in the humane use of animals in research, education and testing. Russell and Burch introduced the concept of the Three Rs in the scientific community and provided a blueprint for combining animal welfare considerations and quality of research.
Uwe Marx is a German physician and biotechnologist, and one of the world’s leading researchers in the fields of organ-on-a-chip technology and antibody production.
