Clostridium cadaveris

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Clostridium cadaveris
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Kingdom: Bacillati
Phylum: Bacillota
Class: Clostridia
Order: Eubacteriales
Family: Clostridiaceae
Genus: Clostridium
Species:
C. cadaveris
Binomial name
Clostridium cadaveris
(Klein 1899) McClung and McCoy 1957
Synonyms
  • Bacillus cadaveris [1]
    Klein 1899
  • Plectridium cadaveris [1]
    (Klein 1899) Prevot 1938

Clostridium cadaveris is an enteric, gas-forming, motile, strictly anaerobic gram-positive bacterium of the genus Clostridium . First described by Klein in 1899, it was noted to be the most prominent bacteria during human decomposition; historically it was described as "putrefying flora".

Contents

Clostridium cadaveris is usually considered non-pathogenic; unlike other species of Clostridium, it does not produce toxins. [2] Clostridium cadaveris is found in soil, water, and is a normal component of the human intestinal tract.

The genus Clostridium is large and phylogenetically diverse, comprising over 150 species. [3] Clostridia are found extensively in nature predominantly as benign soil saprophytes. A number of Clostridium species are pathogenic to humans. Members including C. botulinium, C. perfringens, and C. septicum are spore-forming and the cause of botulism and gas gangrene respectively. Clostridium cadaveris is closely related phylogenetically to Clostridium fallax and Clostridium intestinale. [4]

Infections in humans due to C. cadaveris are rare and the organism is seldom found is clinical specimens. Most cases reported in medical literature document infections in immunocompromised patients, but isolated cases in immunocompetent hosts have been reported. [5] [6]

Colony characteristics

Primary isolation media is blood agar incubated anaerobically at 35–37 degrees Celsius for 40–48 hours. Microscopic appearance shows gram-positive rods with both smooth and rough colony types and further spore staining technique may be utilized to determine spore shape and position. [7] Currently the standard to identify clostridial species such as C. cadaveris is via molecular techniques utilizing ribosomal RNA gene sequencing. [8]

Infections

Infections due to C. cadaveris are rare and present predominantly as bacteremia of gastro-intestinal origin and may occur endogenously. [9] Associated risk factors for bacteremia due to C. cadaveris include a compromised immune system, trauma, recent surgical procedures, diabetes, and perforated bowel. [10] Bacteremia and sepsis caused by C. cadaveris have been implicated following orthopedic procedures, in patients undergoing oncological treatment, and in cases of necrotic decubitus. [11] Due to the rare clinical manifestation of bacteremia attributed to C. cadaveris, the organism's susceptibility to antibiotic treatment is not well documented. Case reports indicate a susceptibility to most antibiotics including metronidazole and penicillin as well as resistance to clindamycin and possibly beta-lactams. [12] Infections may be persistent due to the organisms ability to sporulate. [13]

In human decomposition

In humans, one of the first signs of decomposition is a yellow-green discolorization of the abdomen in the area of the cecum due to the build up of gases from bacteria and autolysis of cells. [14] Clostridium cadaveris, C. welchii, E. coli, and B. aerogenes are found in large numbers after death due to nutrient supply for anaerobic bacteria allowing for optimal organismal growth. [15] In initial stages of decomposition bacteria feed on both intestinal contents and intestinal tissues, prolific colonization occurs allowing digestive enzymes and anaerobic bacteria such as C. cadaveris to breach the intestinal tract invading other tissues and organs. [16] Translocation and proliferation of gut flora such as C. cadaveris allow for these organisms to serve as bacterial indicators for time of death in individuals. [17]

References

  1. 1 2 "Clostridium cadaveris: (Klein 1899) McClung and McCoy 1957". National Center for Biotechnology Information (NCBI).
  2. ↑ Schade, Rogier P.; Van Rijn, Michiel; Timmers, Henri J. L. M.; Dofferhoff, Anton S. M.; Klaassen, Corne H. W.; Meis, Jacques F. G. M. (28 September 2006). "Clostridium cadaveris bacteremia: Two cases and review". Scandinavian Journal of Infectious Diseases. 38 (1): 59–78. doi:10.1080/00365540500388792. PMID   16338840. S2CID   38559710.
  3. ↑ Keto-Timonen, R.; Heikinheimo, A.; Eerola, E.; Korkeala, H. (September 2006). "Identification of Clostridium Species and DNA fingerprinting of Clostridium perfringens" (PDF). Journal of Clinical Microbiology. 44 (11): 4057–65. doi:10.1128/jcm.01275-06. PMC   1698353 . PMID   16971642.
  4. ↑ Elsayed, Sameer; Zhang, Kunyan (April 2005). "Bacteremia Caused by Clostridium Intestinale". Journal of Clinical Microbiology. 43 (4): 2018–2020. doi:10.1128/JCM.43.4.2018-2020.2005. PMC   1081394 . PMID   15815049.
  5. ↑ Gucalp, Rasim; Motyl, Mary; Carlisle, Penny; Dutcher, Janice; Fuks, Joachim; Wiernik, Peter H. (1993). "Clostridium cadaveris bacteremia in the immunocompromised host". Medical and Pediatric Oncology. 21 (1): 70–2. doi:10.1002/mpo.2950210114. PMID   8426578.
  6. ↑ Poduval, Rajiv; Rajesh Mohandas; Dilip Unnikrishnan; Marilou Corpuz (November 1999). "Clostridium cadaveris in an Immunocompetent Host". Clinical Infectious Diseases. 29 (5): 1354–1355. doi: 10.1086/313491 . PMID   10525006.
  7. ↑ Starr, S. E.; Killgore, G. E.; Dowell, V. R. (October 1971). "Comparison of Schaedler Agar and Trypticase Soy-Yeast Extract Agar for the Cultivation of Anaerobic Bacteria". Applied Microbiology. 22 (4): 655–658. doi:10.1128/AEM.22.4.655-658.1971. PMC   376381 . PMID   4943275.
  8. ↑ Woo, P C Y.; Lau, S K P.; Chan, K-m; Fung, A M Y.; Tang, B S F.; Yuen, K-y (2005). "Clostridium bacteramia characterized by 16S ribosomal RNA gene sequencing". Journal of Clinical Pathology. 58 (3): 301–307. doi:10.1136/jcp.2004.022830. PMC   1770585 . PMID   15735165.
  9. ↑ Herman, R.; Goldman, I. S.; Bronzo, R.; McKinley, M. J. (January 1992). "Clostridium cadaveris: an unusual cause of spontaneous bacterial peritonitis". American Journal of Gastroenterology. 87 (1): 140–142. PMID   1728112.
  10. ↑ Elsayed, Sameer; Zhang, Kunyan (April 2005). "Bacteremia caused by Clostridium intestinale". Journal of Clinical Microbiology. 43 (4): 2018–2020. doi:10.1128/jcm.43.4.2018-2020.2005. PMC   1081394 . PMID   15815049.
  11. ↑ Morshed, S.; Malek, F.; Silverstein, R. M.; O'Donnell, R. J. (February 2007). "Clostridium cadaveris septic arthritis after total hip arthroplasty in a metastatic breast cancer patient". J. Athroplasty. 22 (2): 289–292. doi:10.1016/j.arth.2006.02.158. PMID   17275650.
  12. ↑ Willis, A. T. (1977). Anaerobic bacteriology: clinical and laboratory practice. Boston: Butterworth. pp. 111–166.
  13. ↑ Stolk-Engelaar, Virginia; Verwiel, Jeroen; Bongaerts, Ger; Linsen, Vic; Lacquet, Leon; Cox, Anton (July 1997). "Pleural empyema due to Clostridium difficile and Clostridium cadaveris". Clinical Infectious Diseases. 25 (1): 160. doi: 10.1086/516893 . PMID   9243057.
  14. ↑ Ritz, Karl Ritz; Dawson, Lorna; Miller, David (23 December 2008). Criminal and Environmental Soil Forensics. Springer Science. ISBN   978-1-4020-9203-9.
  15. ↑ Sherman, Henry C. (1946). Chemistry of Food (7th ed.). New York: MacMillan and Company. OCLC   567049.
  16. ↑ Vass, Arpab (November 2001). "Beyond the grave - understanding human decomposition". Microbiology Today. 28: 190–192. Archived from the original on 7 February 2016. Retrieved 6 February 2016.
  17. ↑ Melvin, JR; Cronholm, LS; Simson, LR; Isaacs, AM (April 1984). "Bacterial Transmigration as an indicator of time of death". Journal of Forensic Sciences. 29 (2): 412–417. doi:10.1520/JFS11687J. PMID   6726153.
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