DBR1

DBR1
Identifiers
Aliases	DBR1 , debranching RNA lariats 1
External IDs	OMIM: 607024 MGI: 1931520 HomoloGene: 9428 GeneCards: DBR1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	138,174,921 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	99,466,554 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; amniotic fluid; ; germinal epithelium; ; ganglionic eminence; ; islet of Langerhans; ; endometrium; ; internal globus pallidus; ; monocyte; ; body of pancreas; ; spleen;
	Top expressed in
	primitive streak; ; abdominal wall; ; hair follicle; ; medial ganglionic eminence; ; trigeminal ganglion; ; maxillary prominence; ; motor neuron; ; barrel cortex; ; semi-lunar valve; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity ; RNA lariat debranching enzyme activity ; hydrolase activity, acting on ester bonds ; metal ion binding ; RNA binding ;
Cellular component	nucleus ; nucleoplasm ;
Biological process	RNA splicing, via transesterification reactions ; mRNA splicing, via spliceosome ; mRNA processing ; RNA phosphodiester bond hydrolysis, endonucleolytic ;
	Sources:Amigo / QuickGO
Orthologs
	51163
	83703
	ENSG00000138231
	ENSMUSG00000032469
	Q9UK59
	Q923B1
	NM_016216
	NM_031403 ; NM_001368298
	NP_057300
	NP_113580 ; NP_001355227
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Lariat debranching enzyme is a protein that in humans is encoded by the DBR1 gene.^[5]^[6]

The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules.[supplied by OMIM]^[6]

Related Research Articles

RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger RNA (mRNA). It works by removing all the introns and splicing back together exons. For nuclear-encoded genes, splicing occurs in the nucleus either during or immediately after transcription. For those eukaryotic genes that contain introns, splicing is usually needed to create an mRNA molecule that can be translated into protein. For many eukaryotic introns, splicing occurs in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs). There exist self-splicing introns, that is, ribozymes that can catalyze their own excision from their parent RNA molecule. The process of transcription, splicing and translation is called gene expression, the central dogma of molecular biology.

Pre-mRNA-processing factor 19 is a protein that in humans is encoded by the PRPF19 gene.

Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.

REX2, RNA exonuclease 2 homolog , also known as REXO2, is an enzyme which in humans is encoded by the REXO2 gene.

Probable ATP-dependent RNA helicase DDX56 is an enzyme that in humans is encoded by the DDX56 gene.

Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene.

mRNA-capping enzyme is a protein that in humans is encoded by the RNGTT gene.

Methionine aminopeptidase 1 is an enzyme that in humans is encoded by the METAP1 gene.

Protein phosphatase 1G is an enzyme that in humans is encoded by the PPM1G gene.

60S ribosomal protein L30 is a protein that in humans is encoded by the RPL30 gene.

DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.

RNA polymerase-associated protein LEO1 is an enzyme that in humans is encoded by the LEO1 gene.

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.

tRNA -methyltransferase is an enzyme that in humans is encoded by the METTL1 gene.

DNA-directed RNA polymerase III subunit RPC5 is an enzyme that in humans is encoded by the POLR3E gene.

<span class="mw-page-title-main">DDX50</span> Protein-coding gene in the species Homo sapiens

ATP-dependent RNA helicase DDX50 is an enzyme that in humans is encoded by the DDX50 gene.

GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene.

tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene.

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.

Serine/threonine-protein kinase haspin is an enzyme that in humans is encoded by the GSG2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138231 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032469 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kim JW, Kim HC, Kim GM, Yang JM, Boeke JD, Nam K (Sep 2000). "Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants". Nucleic Acids Res. 28 (18): 3666–73. doi:10.1093/nar/28.18.3666. PMC 110720 . PMID 10982890.
1 2 "Entrez Gene: DBR1 debranching enzyme homolog 1 (S. cerevisiae)".

Chapman KB, Boeke JD (1991). "Isolation and characterization of the gene encoding yeast debranching enzyme". Cell. 65 (3): 483–92. doi:10.1016/0092-8674(91)90466-C. PMID 1850323. S2CID 39225964.
Arenas J, Hurwitz J (1987). "Purification of a RNA debranching activity from HeLa cells". J. Biol. Chem. 262 (9): 4274–9. doi: 10.1016/S0021-9258(18)61343-2 . PMID 2435736.
Martin A, Schneider S, Schwer B (2002). "Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome". J. Biol. Chem. 277 (20): 17743–50. doi: 10.1074/jbc.M200762200 . PMID 11886864.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ye Y, De Leon J, Yokoyama N, et al. (2006). "DBR1 siRNA inhibition of HIV-1 replication". Retrovirology. 2: 63. doi: 10.1186/1742-4690-2-63 . PMC 1266399 . PMID 16232320.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138231 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032469 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10982890-5] Kim JW, Kim HC, Kim GM, Yang JM, Boeke JD, Nam K (Sep 2000). "Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants". Nucleic Acids Res. 28 (18): 3666–73. doi:10.1093/nar/28.18.3666. PMC 110720 . PMID 10982890.

[entrez-6] 1 2 "Entrez Gene: DBR1 debranching enzyme homolog 1 (S. cerevisiae)".

[1]

[2]

[3]

[4]

[5]

[6]

DBR1

Related Research Articles

References

Further reading