DCDC2

Last updated
DCDC2
Protein DCDC2 PDB 2dnf.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DCDC2 , DCDC2A, DFNB66, NPHP19, RU2, RU2S, doublecortin domain containing 2, NSC
External IDs OMIM: 605755; MGI: 2652818; HomoloGene: 9483; GeneCards: DCDC2; OMA:DCDC2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016356
NM_001195610

NM_001195617
NM_177577

RefSeq (protein)

NP_001182539
NP_057440

NP_001182546
NP_808245

Location (UCSC) Chr 6: 24.17 – 24.36 Mb Chr 13: 25.24 – 25.39 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Doublecortin domain-containing protein 2 (DCDC2) is a protein that in humans is encoded by the DCDC2 gene. [5] [6] [7]

Contents

Function

This gene encodes a protein with two doublecortin peptide domains. This domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [7]

Clinical significance

Mutations in this gene have been associated with reading disability (RD), also referred to as developmental dyslexia. [7] [8] But this is controverse since a recent study proposed that there is a "low likelihood of a direct deletion effect on reading skills." [9] Changes in the DCDC2 gene are frequently found among dyslexics. Altered alleles often occur among children with reading and writing difficulties. The gene appears to have a strong linkage with the processing of speech information when writing. [10] [11] [12]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000146038 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035910 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Van Den Eynde BJ, Gaugler B, Probst-Kepper M, Michaux L, Devuyst O, Lorge F, Weynants P, Boon T (Jan 2000). "A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription". J Exp Med. 190 (12): 1793–800. doi:10.1084/jem.190.12.1793. PMC   2195717 . PMID   10601354.
  6. Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID   10574461.
  7. 1 2 3 "Entrez Gene: DCDC2 doublecortin domain containing 2".
  8. Lind PA, Luciano M, Wright MJ, Montgomery GW, Martin NG, Bates TC (June 2010). "Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample". Eur. J. Hum. Genet. 18 (6): 668–73. doi:10.1038/ejhg.2009.237. PMC   2987340 . PMID   20068590.
  9. Scerri TS, Macpherson E, Martinelli A, Wa WC, Monaco AP, Stein J, Zheng M, Suk-Han C, McBride C, Snowling M, Hulme C, Hayiou-Thomas ME, Waye M, Talcott JB, Paracchini S (2017). "The DCDC2 deletion is not a risk factor for dyslexia". Transl Psychiatry. 7 (7): e1182. doi:10.1038/tp.2017.151. PMC   5538127 . PMID   28742079.
  10. Meng H, Smith SD, Hager K, Held M, Liu J, Olson RK, Pennington BF, DeFries JC, Gelernter J, O'Reilly-Pol T, Somlo S, Skudlarski P, Shaywitz SE, Shaywitz BA, Marchione K, Wang Y, Paramasivam M, LoTurco JJ, Page GP, Gruen JR (November 2005). "DCDC2 is associated with reading disability and modulates neuronal development in the brain". Proc. Natl. Acad. Sci. U.S.A. 102 (47): 17053–8. doi: 10.1073/pnas.0508591102 . PMC   1278934 . PMID   16278297.
  11. Schumacher, J.; Anthoni H.; Dadouh F.; et al. (Jan 2006). "Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia" (PDF). The American Journal of Human Genetics. 78 (1): 52–62. doi:10.1086/498992. PMC   1380223 . PMID   16385449. Archived from the original (PDF) on 2013-05-15.
  12. Marino C, Meng H, Mascheretti S, Rusconi M, Cope N, Giorda R, Molteni M, Gruen JR (February 2012). "DCDC2 genetic variants and susceptibility to developmental dyslexia". Psychiatr. Genet. 22 (1): 25–30. doi:10.1097/YPG.0b013e32834acdb2. PMC   3232293 . PMID   21881542.

Further reading