DEDD

Last updated
DEDD
Identifiers
Aliases DEDD , CASP8IP1, DEDD1, DEFT, FLDED1, KE05, death effector domain containing
External IDs OMIM: 606841; MGI: 1333874; HomoloGene: 7980; GeneCards: DEDD; OMA:DEDD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039711
NM_001039712
NM_004216
NM_032998
NM_001330765

Contents

RefSeq (protein)

NP_001034800
NP_001034801
NP_001317694
NP_127491

Location (UCSC) Chr 1: 161.12 – 161.13 Mb Chr 1: 171.16 – 171.17 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Death effector domain containing protein is a protein that in humans is encoded by the DEDD gene. [5] [6] [7]

Function

This gene encodes a protein that contains a death effector domain (DED). DED is a protein–protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [7]

Interactions

DEDD has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000158796 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013973 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Dec 1998). "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus". EMBO J. 17 (20): 5974–86. doi:10.1093/emboj/17.20.5974. PMC   1170924 . PMID   9774341.
  6. Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ (Dec 1998). "DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells". Endocrinology. 139 (12): 4839–48. doi: 10.1210/endo.139.12.6335 . PMID   9832420.
  7. 1 2 "Entrez Gene: DEDD death effector domain containing".
  8. 1 2 Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (Apr 2002). "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC". Cell Death Differ. 9 (4): 439–47. doi: 10.1038/sj.cdd.4401038 . PMID   11965497.
  9. 1 2 Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC (Mar 2002). "Identification and characterization of DEDD2, a death effector domain-containing protein". J. Biol. Chem. 277 (9): 7501–8. doi: 10.1074/jbc.M110749200 . PMID   11741985.
  10. Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Oct 1998). "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus". EMBO J. 17 (20): 5974–86. doi:10.1093/emboj/17.20.5974. PMC   1170924 . PMID   9774341.
  11. Alcivar A, Hu S, Tang J, Yang X (Jan 2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death". Oncogene. 22 (2): 291–7. doi: 10.1038/sj.onc.1206099 . PMID   12527898.

Further reading