DEK (gene)

DEK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q1V, 2JX3
Identifiers
Aliases	DEK , D6S231E, DEK proto-oncogene
External IDs	OMIM: 125264; MGI: 1926209; HomoloGene: 2593; GeneCards: DEK; OMA:DEK - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.3 Start 18,223,860 bp [1] End 18,264,548 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13 A5|13 24.5 cM Start 47,238,251 bp [2] End 47,259,677 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of nasopharynx ventricular zone tibia ganglionic eminence trabecular bone amniotic fluid germinal epithelium skin of hip jejunal mucosa Top expressed in tail of embryo zygote genital tubercle secondary oocyte primary oocyte epiblast bone marrow ventricular zone thymus yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding histone binding chromatin binding RNA binding Cellular component nucleoplasm contractile fiber nucleus Biological process epigenetic maintenance of chromatin in transcription-competent conformation viral genome replication regulation of double-strand break repair via nonhomologous end joining transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of double-strand break repair signal transduction chromatin remodeling chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7913 110052 Ensembl ENSG00000124795 ENSMUSG00000021377 UniProt P35659 Q7TNV0 RefSeq (mRNA) NM_001134709 NM_003472 NM_025900 RefSeq (protein) NP_001128181 NP_003463 NP_080176 Location (UCSC) Chr 6: 18.22 – 18.26 Mb Chr 13: 47.24 – 47.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The human DEKgene encodes the DEK protein. ^{[5] [6]}

Function

This gene encodes a protein with one SAP domain. The protein binds to cruciform DNA and DNA coiled into a superhelix, thereby inducing positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases. ^[6]

Interactions

DEK interacts with TFAP2A. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000124795 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021377 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G (Apr 1992). "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Mol. Cell. Biol. 12 (4): 1687–97. doi:10.1128/mcb.12.4.1687. PMC   369612 . PMID   1549122.
6. "Entrez Gene: DEK DEK oncogene (DNA binding)".
7. Campillos M, García MA, Valdivieso F, Vázquez J (Mar 2003). "Transcriptional activation by AP-2alpha is modulated by the oncogene DEK". Nucleic Acids Res. 31 (5): 1571–5. doi:10.1093/nar/gkg247. PMC   149840 . PMID   12595566.

Further reading

• von Lindern M, Fornerod M, Soekarman N, van Baal S, Jaegle M, Hagemeijer A, Bootsma D, Grosveld G (1992). "Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene". Baillière's Clinical Haematology. 5 (4): 857–79. doi:10.1016/s0950-3536(11)80049-1. PMID   1308167.
• Waldmann T, Scholten I, Kappes F, Hu HG, Knippers R (2004). "The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin". Gene. 343 (1): 1–9. doi:10.1016/j.gene.2004.08.029. PMID   15563827.
• Denisenko ON, O'Neill B, Ostrowski J, Van Seuningen I, Bomsztyk K (1996). "Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein". J. Biol. Chem. 271 (44): 27701–6. doi: 10.1074/jbc.271.44.27701 . PMID   8910362.
• Fu GK, Grosveld G, Markovitz DM (1997). "DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1811–5. Bibcode:1997PNAS...94.1811F. doi: 10.1073/pnas.94.5.1811 . PMC   19999 . PMID   9050861.
• Murray KJ, Szer W, Grom AA, Donnelly P, Levinson JE, Giannini EH, Glass DN, Szer IS (1997). "Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene". J. Rheumatol. 24 (3): 560–7. PMID   9058666.
• Forero L, Zwirner NW, Fink CW, Fernández-Viña MA, Stastny P (1998). "Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides". Hum. Immunol. 59 (7): 443–50. doi:10.1016/S0198-8859(98)00034-2. PMID   9684994.
• Dong X, Michelis MA, Wang J, Bose R, DeLange T, Reeves WH (1998). "Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis". Arthritis Rheum. 41 (8): 1505–10. doi:10.1002/1529-0131(199808)41:8<1505::AID-ART23>3.0.CO;2-N. PMID   9704652.
• Wichmann I, Garcia-Lozano JR, Respaldiza N, Gonzalez-Escribano MF, Nuñez-Roldan A (1999). "Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus". Hum. Immunol. 60 (1): 57–62. doi:10.1016/S0198-8859(98)00085-8. PMID   9952027.
• Alexiadis V, Waldmann T, Andersen J, Mann M, Knippers R, Gruss C (2000). "The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner". Genes Dev. 14 (11): 1308–12. doi:10.1101/gad.14.11.1308. PMC   316669 . PMID   10837023.
• McGarvey T, Rosonina E, McCracken S, Li Q, Arnaout R, Mientjes E, Nickerson JA, Awrey D, Greenblatt J, Grosveld G, Blencowe BJ (2000). "The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes". J. Cell Biol. 150 (2): 309–20. doi:10.1083/jcb.150.2.309. PMC   2180225 . PMID   10908574.
• Grottke C, Mantwill K, Dietel M, Schadendorf D, Lage H (2000). "Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs". Int. J. Cancer. 88 (4): 535–46. doi:10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V. PMID   11058868. S2CID   24030621.
• Le Hir H, Izaurralde E, Maquat LE, Moore MJ (2000). "The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions". EMBO J. 19 (24): 6860–9. doi:10.1093/emboj/19.24.6860. PMC   305905 . PMID   11118221.
• Kappes F, Burger K, Baack M, Fackelmayer FO, Gruss C (2001). "Subcellular localization of the human proto-oncogene protein DEK". J. Biol. Chem. 276 (28): 26317–23. doi: 10.1074/jbc.M100162200 . PMID   11333257.
• Waldmann T, Eckerich C, Baack M, Gruss C (2002). "The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils". J. Biol. Chem. 277 (28): 24988–94. doi: 10.1074/jbc.M204045200 . PMID   11997399.
• Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S (2002). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica. 87 (6): 569–77. PMID   12031912.
• Hollenbach AD, McPherson CJ, Mientjes EJ, Iyengar R, Grosveld G (2002). "Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek". J. Cell Sci. 115 (Pt 16): 3319–30. doi:10.1242/jcs.115.16.3319. PMID   12140263.
• Krithivas A, Fujimuro M, Weidner M, Young DB, Hayward SD (2002). "Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes". J. Virol. 76 (22): 11596–604. doi:10.1128/JVI.76.22.11596-11604.2002. PMC   136775 . PMID   12388720.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein DEK