DLG3

Last updated

DLG3
Protein DLG3 PDB 1um7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DLG3 , MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR, discs large homolog 3, discs large MAGUK scaffold protein 3, XLID90
External IDs OMIM: 300189; MGI: 1888986; HomoloGene: 41157; GeneCards: DLG3; OMA:DLG3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166278
NM_020730
NM_021120

NM_001177778
NM_001177779
NM_001177780
NM_001290402
NM_016747

Contents

RefSeq (protein)

NP_001159750
NP_065781
NP_066943

NP_001171249
NP_001171250
NP_001171251
NP_001277331
NP_058027

Location (UCSC) Chr X: 70.44 – 70.51 Mb Chr X: 99.81 – 99.86 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene. [5] [6] DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Interactions

DLG3 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000082458 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000881 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Stathakis DG, Lee D, Bryant PJ (Aug 1998). "DLG3, the gene encoding human neuroendocrine Dlg (NE-Dlg), is located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1". Genomics. 49 (2): 310–3. doi:10.1006/geno.1998.5243. PMID   9598320.
  6. "Entrez Gene: DLG3 Discs, large homolog 3 (neuroendocrine-dlg, Drosophila)".
  7. Makino K, Kuwahara H, Masuko N, Nishiyama Y, Morisaki T, Sasaki J, Nakao M, Kuwano A, Nakata M, Ushio Y, Saya H (May 1997). "Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein". Oncogene. 14 (20): 2425–33. doi:10.1038/sj.onc.1201087. PMID   9188857. S2CID   6554126.
  8. 1 2 3 4 Lim IA, Hall DD, Hell JW (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24): 21697–711. doi: 10.1074/jbc.M112339200 . PMID   11937501.
  9. Masuko N, Makino K, Kuwahara H, Fukunaga K, Sudo T, Araki N, Yamamoto H, Yamada Y, Miyamoto E, Saya H (Feb 1999). "Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90. A possible regulatory role in molecular clustering at synaptic sites". J. Biol. Chem. 274 (9): 5782–90. doi: 10.1074/jbc.274.9.5782 . PMID   10026200.
  10. 1 2 3 Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ (Jun 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol. 5 (6): 520–30. doi:10.1038/ncb990. PMID   12738960. S2CID   13444388.
  11. 1 2 Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Südhof TC (Sep 1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID   9278515.
  12. Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y (Jun 2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses". Am. J. Physiol., Cell Physiol. 282 (6): C1396-403. doi:10.1152/ajpcell.00615.2001. PMID   11997254.
  13. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi: 10.1074/jbc.M400285200 . PMID   15024025.
  14. Seabold GK, Burette A, Lim IA, Weinberg RJ, Hell JW (Apr 2003). "Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102". J. Biol. Chem. 278 (17): 15040–8. doi: 10.1074/jbc.M212825200 . PMID   12576483.
  15. Kim JH, Liao D, Lau LF, Huganir RL (Apr 1998). "SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family". Neuron. 20 (4): 683–91. doi: 10.1016/S0896-6273(00)81008-9 . PMID   9581761.

Further reading