DLK1

Last updated
DLK1
Identifiers
Aliases DLK1 , DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2, AW742678, DlkI, Ly107, Peg9, SCP1, delta like non-canonical Notch ligand 1
External IDs OMIM: 176290 MGI: 94900 HomoloGene: 2846 GeneCards: DLK1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001032997
NM_003836
NM_001317172

NM_001190703
NM_001190704
NM_001190705
NM_010052

RefSeq (protein)

NP_001304101
NP_003827
NP_003827.3

NP_001177632
NP_001177633
NP_001177634
NP_034182

Location (UCSC) Chr 14: 100.73 – 100.74 Mb Chr 12: 109.42 – 109.43 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein delta homolog 1, delta like non-canonical Notch ligand 1, fetal antigen 1 [5] or preadipocyte factor 1 [6] is a protein that in humans is encoded by the DLK1 gene. [7] [8] [9]

It is expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis, [10] the differentiation of pre-adipocytes into adipocytes. [11]

It is a member of the EGF-like family of homeotic proteins. [12]

Part of the Dlk1-DIO3 imprinting control region, this gene is one involved in the epigenetic process that causes a subset of genes to be regulated based on their parental origin. [13]

Such imprinted genes are required for the formation of the placenta as well as the development of cellular lineages such as those derived from the mesoderm and ectoderm. [14]

Related Research Articles

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<span class="mw-page-title-main">Adipogenesis</span>

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<span class="mw-page-title-main">TBX15</span> Human protein and coding gene

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000185559 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040856 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jensen C, Teisner B, Højrup P, Rasmussen H, Madsen O, Nielsen B, Skjødt K (1993). "Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2". Human Reproduction. 8 (4): 635–641. doi:10.1093/oxfordjournals.humrep.a138110. PMID   8501199.
  6. Smas CM, Sul HS (1993). "Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation". Cell. 73 (4): 725–734. doi:10.1016/0092-8674(93)90252-L. PMID   8500166. S2CID   23634189.
  7. Laborda J, Sausville EA, Hoffman T, Notario V (1993). "dlk, a Putative Mammalian Homeotic Gene Differentially Expressed in Small Cell Lung Carcinoma and Neuroendocrine Tumor Cell Line". The Journal of Biological Chemistry. 268 (6): 3817–20. doi: 10.1016/S0021-9258(18)53544-4 . PMID   8095043.
  8. Jensen CH, Krogh TN, Højrup P, Clausen PP, Skjødt K, Larsson LI, Enghild JJ, Teisner B (1994). "Protein Structure of Fetal Antigen 1 (FA1). A Novel Circulating Human Epidermal-Growth-Factor-Like Protein Expressed in Neuroendocrine Tumors and its Relation to the Gene Products of Dlk and pG2". European Journal of Biochemistry. 225 (1): 83–92. doi:10.1111/j.1432-1033.1994.00083.x. PMID   7925474.
  9. EntrezGene 8788
  10. Wang Y, Sul HS (2009). "Pref-1 Regulates Mesenchymal Cell Commitment and Differentiation through Sox9". Cell Metabolism. 9 (3): 287–302. doi:10.1016/j.cmet.2009.01.013. PMC   2673480 . PMID   19254573.
  11. Adipogenesis at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  12. Laborda J (2000). "The role of the epidermal growth factor-like protein dlk in cell differentiation". Histology and Histopathology. 15 (1): 119–29. PMID   10668203.
  13. Lin SP, Coan P, da Rocha ST, Seitz H, Cavaille J, Teng PW, Takada S, Ferguson-Smith AC (Jan 2007). "Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region". Development. 134 (2): 417–426. doi: 10.1242/dev.02726 . PMID   17166925.
  14. Hernandez A, Fiering S, Martinez E, Galton VA, St Germain D (Nov 2002). "The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts". Endocrinology. 143 (11): 4483–4486. doi: 10.1210/en.2002-220800 . PMID   12399446.

Further reading