DMP1

DMP1
Identifiers
Aliases	DMP1 , ARHP, ARHR, DMP-1, dentin matrix acidic phosphoprotein 1
External IDs	OMIM: 600980; MGI: 94910; HomoloGene: 68396; GeneCards: DMP1; OMA:DMP1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	87,664,361 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	104,361,968 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; tibia; ; testicle; ; trabecular bone; ; tendon of biceps brachii; ; sperm; ; mucosa of paranasal sinus; ; lateral nuclear group of thalamus; ; upper respiratory tract; ; sensory nervous system;
	Top expressed in
	body of femur; ; fossa; ; molar; ; cochlea; ; calvaria; ; lumbar subsegment of spinal cord; ; ankle; ; facial motor nucleus; ; condyle; ; otolith organ;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding ; integrin binding ; extracellular matrix binding ;
Cellular component	cytoplasm ; extracellular region ; nucleus ; endoplasmic reticulum lumen ; extracellular matrix ;
Biological process	biomineral tissue development ; extracellular matrix organization ; ossification ; positive regulation of cell-substrate adhesion ; regulation of enamel mineralization ; post-translational protein modification ;
	Sources:Amigo / QuickGO
Orthologs
	1758
	13406
	ENSG00000152592
	ENSMUSG00000029307
	Q13316
	O55188
	NM_001079911 ; NM_004407
	NM_016779 ; NM_001359013
	NP_001073380 ; NP_004398
	NP_058059 ; NP_001345942
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 23, 2024

Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene.^[5]^[6]^[7]

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family (other members being DSPP, IBSP, MEPE, and SPP1). This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional Arg-Gly-Asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.^[7]

Related Research Articles

Bone sialoprotein (BSP) is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. BSP is a significant component of the bone extracellular matrix and has been suggested to constitute approximately 8% of all non-collagenous proteins found in bone and cementum. BSP, a SIBLING protein, was originally isolated from bovine cortical bone as a 23-kDa glycopeptide with high sialic acid content.

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Vasodilator-stimulated phosphoprotein is a protein that in humans is encoded by the VASP gene.

Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene.

<span class="mw-page-title-main">ADAMTS1</span> Protein-coding gene in the species Homo sapiens

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Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.

Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene.

Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene.

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein, is a protein that in humans is encoded by the MST1 gene.

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.

Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

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Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2

Disintegrin and metalloproteinase domain-containing protein 28 is an enzyme that in humans is encoded by the ADAM28 gene.

Matrix extracellular phosphoglycoprotein is a protein that in humans is encoded by the MEPE gene. A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.

Dentin sialophosphoprotein is a precursor protein for other proteins found in the teeth. It is produced by cells (odontoblasts) inside the teeth, and in smaller quantities by bone tissues. It is required for normal hardening (mineralisation) of teeth. During teeth development, it is broken down into three proteins such as dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). These proteins become the major non-collagenous components of teeth. Their distribution in the collagen matrix of the forming dentin suggests these proteins play an important role in the regulation of mineral deposition. Additional evidence for this correlation is phenotypically manifested in patients with mutant forms of dentin sialophosphoprotein. Such patients suffer dental anomalies including type III dentinogenesis imperfecta.

Dentin sialoprotein is a protein found in teeth. It is one of the two proteins produced by the segmentation of dentin sialophosphoprotein. Dentin sialoprotein can be found in the dentin immediately subjacent to cellular cementum, but not subjacent to acellular fibrous cementum.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152592 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029307 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Aplin HM, Hirst KL, Crosby AH, Dixon MJ (Mar 1996). "Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21". Genomics. 30 (2): 347–9. doi:10.1006/geno.1995.9867. PMID 8586437.
↑ Hirst KL, Simmons D, Feng J, Aplin H, Dixon MJ, MacDougall M (Jul 1997). "Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II". Genomics. 42 (1): 38–45. doi:10.1006/geno.1997.4700. PMID 9177774.
1 2 "Entrez Gene: DMP1 dentin matrix acidic phosphoprotein".

Cell Cycle-Dependent Nuclear Localization of DMP1

J.O. MANCERA1, T. JHALA2, S. WANG2, C. QIN2, R. D'SOUZA2, and Y. LU2, 1School of Dentistry, Meharry Medical College, Nashville, TN, 2Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX

George A, Sabsay B, Simonian PA, Veis A (1993). "Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization". J. Biol. Chem. 268 (17): 12624–30. doi: 10.1016/S0021-9258(18)31434-0 . PMID 8509401.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID 8889549.
Srinivasan R, Chen B, Gorski JP, George A (2000). "Recombinant expression and characterization of dentin matrix protein 1". Connect. Tissue Res. 40 (4): 251–8. doi:10.3109/03008209909000703. PMID 10757113.
Kulkarni GV, Chen B, Malone JP, et al. (2000). "Promotion of selective cell attachment by the RGD sequence in dentine matrix protein 1". Arch. Oral Biol. 45 (6): 475–84. doi:10.1016/S0003-9969(00)00010-8. PMID 10775676.
Jain A, Karadag A, Fohr B, et al. (2002). "Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack". J. Biol. Chem. 277 (16): 13700–8. doi: 10.1074/jbc.M110757200 . PMID 11825898.
Papagerakis P, Berdal A, Mesbah M, et al. (2002). "Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth". Bone. 30 (2): 377–85. doi:10.1016/S8756-3282(01)00683-4. PMID 11856645.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Narayanan K, Ramachandran A, Hao J, et al. (2003). "Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store". J. Biol. Chem. 278 (19): 17500–8. doi: 10.1074/jbc.M212700200 . PMID 12615915.
Chaplet M, De Leval L, Waltregny D, et al. (2004). "Dentin matrix protein 1 is expressed in human lung cancer". J. Bone Miner. Res. 18 (8): 1506–12. doi: 10.1359/jbmr.2003.18.8.1506 . PMID 12929940. S2CID 24870810.
Steiglitz BM, Ayala M, Narayanan K, et al. (2004). "Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1". J. Biol. Chem. 279 (2): 980–6. doi: 10.1074/jbc.M310179200 . PMID 14578349.
Toyosawa S, Tomita Y, Kishino M, et al. (2004). "Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia". Mod. Pathol. 17 (5): 573–8. doi: 10.1038/modpathol.3800084 . PMID 15001995.
Chen S, Inozentseva-Clayton N, Dong J, et al. (2005). "Binding of two nuclear factors to a novel silencer element in human dentin matrix protein 1 (DMP1) promoter regulates the cell type-specific DMP1 gene expression". J. Cell. Biochem. 92 (2): 332–49. doi:10.1002/jcb.20051. PMID 15108359. S2CID 31421133.
Ogbureke KU, Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands". J. Dent. Res. 83 (9): 664–70. doi:10.1177/154405910408300902. PMID 15329369. S2CID 17978869.
Yang W, Lu Y, Kalajzic I, et al. (2005). "Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo". J. Biol. Chem. 280 (21): 20680–90. doi: 10.1074/jbc.M500104200 . PMID 15728181.
Ogbureke KU, Fisher LW (2005). "Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)". Kidney Int. 68 (1): 155–66. doi: 10.1111/j.1523-1755.2005.00389.x . PMID 15954904.
Ling Y, Rios HF, Myers ER, et al. (2006). "DMP1 Depletion Decreases Bone Mineralization In Vivo: An FTIR Imaging Analysis". J. Bone Miner. Res. 20 (12): 2169–77. doi:10.1359/JBMR.050815. PMC 1456072 . PMID 16294270.
Karadag A, Fedarko NS, Fisher LW (2006). "Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins and CD44". Cancer Res. 65 (24): 11545–52. doi:10.1158/0008-5472.CAN-05-2861. PMC 1350722 . PMID 16357164.
Qin C, Huang B, Wygant JN, et al. (2006). "A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment". J. Biol. Chem. 281 (12): 8034–40. doi: 10.1074/jbc.M512964200 . PMID 16421105.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000152592 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029307 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8586437-5] Aplin HM, Hirst KL, Crosby AH, Dixon MJ (Mar 1996). "Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21". Genomics. 30 (2): 347–9. doi:10.1006/geno.1995.9867. PMID 8586437.

[pmid9177774-6] Hirst KL, Simmons D, Feng J, Aplin H, Dixon MJ, MacDougall M (Jul 1997). "Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II". Genomics. 42 (1): 38–45. doi:10.1006/geno.1997.4700. PMID 9177774.

[entrez-7] 1 2 "Entrez Gene: DMP1 dentin matrix acidic phosphoprotein".

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DMP1

Related Research Articles

References

Further reading