Daf-12

Nuclear hormone receptor family member daf-12
Identifiers
Organism	Caenorhabditis elegans
Symbol	daf-12
Alt. symbols	NR1J1
Entrez	181263
RefSeq (mRNA)	NM_001029376.5
RefSeq (Prot)	NP_001024547.1
UniProt	G5EFF5
Other data
Chromosome	X: 10.64 - 10.67 Mb
Search for Structures Swiss-model Domains InterPro

The DAF-12 (abnormal dauer formation protein 12) gene encodes the nuclear receptor of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans , with the NRNC Symbol NR1J1 as the homolog of nuclear hormone receptor HR96 (Hr96) in Drosophila melanogaster. ^[1] DAF-12 has been implicated by Cynthia Kenyon and colleagues in the formation of Dauer larva. ^[2]

In favorable environments, a cytochrome p450 Daf-9 (Cyp22a1) ^[3] produce dafachronic acid to binding Daf-12 to initiating downstream gene expression. ^[4] When in unfavorable environments, like starvation, dafachronic acid decreases, Daf-12 will form a complex with co-repressor DIN-1. ^[5]

References

1. Kaur S, Jobling S, Jones CS, Noble LR, Routledge EJ, Lockyer AE (7 April 2015). "The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: implications for developing new model organisms". PLOS ONE . 10 (4): e0121259. Bibcode:2015PLoSO..1021259K. doi: 10.1371/journal.pone.0121259 . PMC   4388693 . PMID   25849443.
2. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993). "A C. elegans mutant that lives twice as long as wild type". Nature . 366 (6454): 461–464. Bibcode:1993Natur.366..461K. doi:10.1038/366461a0. PMID   8247153. S2CID   4332206.
3. Jia K, Albert PS, Riddle DL (2002). "DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity". Development . 129 (1): 221–31. doi:10.1242/dev.129.1.221. PMID   11782415.
4. Aguilaniu H, Fabrizio P, Witting M (2016). "The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry". Frontiers in Endocrinology . 7: 12. doi: 10.3389/fendo.2016.00012 . PMC   4749721 . PMID   26903948.
5. Bento G, Ogawa A, Sommer RJ (July 2010). "Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolution". Nature . 466 (7305): 494–7. Bibcode:2010Natur.466..494B. doi:10.1038/nature09164. PMID   20592728. S2CID   4405326.