Daf-9

Cytochrome P450 daf-9
Identifiers
Organism	Caenorhabditis elegans
Symbol	daf-9
Alt. symbols	CYP22A1
Entrez	180889
RefSeq (mRNA)	NM_001029732.2
RefSeq (Prot)	NP_001024903.1
UniProt	H2KYS3
Other data
Chromosome	X: 6.2 - 6.2 Mb
Search for Structures Swiss-model Domains InterPro

The daf-9 gene encodes a cytochrome p450 enzyme that catalyses the generation of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans , ^{[1] [2]} with the CYP Symbol CYP22A1 (Cytochrome P450, family 22, member A1). After generation, dafachronic acid will bind its nuclear receptor Daf-12, whose genetic mutation has been implicated by Cynthia Kenyon and colleagues as related to the formation of Dauer larva. ^[3]

References

1. Jia K, Albert PS, Riddle DL (2002). "DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity". Development . 129 (1): 221–31. doi:10.1242/dev.129.1.221. PMID   11782415.
2. Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ (2006). "Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans". Cell. 124 (6): 1209–1223. doi: 10.1016/j.cell.2006.01.037 . PMID   16529801.
3. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993). "A C. elegans mutant that lives twice as long as wild type". Nature . 366 (6454): 461–464. Bibcode:1993Natur.366..461K. doi:10.1038/366461a0. PMID   8247153. S2CID   4332206.