Abietadienol hydroxylase

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Abieta-7,13-dien-18-ol hydroxylase
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EC no. 1.14.13.109
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Abieta-7,13-dien-18-ol hydroxylase (EC 1.14.13.109, CYP720B1, PTAO) is an enzyme with systematic name abieta-7,13-dien-18-ol,NADPH:oxygen oxidoreductase (18-hydroxylating). [1] [2] [3] This enzyme catalyses the following chemical reaction

abieta-7,13-dien-18-ol + NADPH + H+ + O2 abieta-7,13-dien-18-al + NADP+ + 2 H2O (overall reaction)
(1a) abieta-7,13-dien-18-ol + NADPH + H+ + O2 abieta-7,13-dien-18,18-diol + + NADP+ + H2O:
(1b) abieta-7,13-dien-18,18-diol abieta-7,13-dien-18-al + H2O (spontaneous)

Abietadienol hydroxylase is a heme-thiolate protein (P-450).

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Abieta-7,13-dien-18-al dehydrogenase (EC 1.2.1.74, abietadienal dehydrogenase (ambiguous)) is an enzyme with systematic name abieta-7,13-dien-18-al:NAD+ oxidoreductase. This enzyme catalyses the following chemical reaction

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References

  1. ↑ Funk C, Croteau R (January 1994). "Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis". Archives of Biochemistry and Biophysics. 308 (1): 258–66. doi:10.1006/abbi.1994.1036. PMID   8311462.
  2. ↑ Funk C, Lewinsohn E, Vogel BS, Steele CL, Croteau R (November 1994). "Regulation of Oleoresinosis in Grand Fir (Abies grandis) (Coordinate Induction of Monoterpene and Diterpene Cyclases and Two Cytochrome P450-Dependent Diterpenoid Hydroxylases by Stem Wounding)". Plant Physiology. 106 (3): 999–1005. doi:10.1104/pp.106.3.999. PMC   159624 . PMID   12232380.
  3. ↑ Ro DK, Arimura G, Lau SY, Piers E, Bohlmann J (May 2005). "Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase". Proceedings of the National Academy of Sciences of the United States of America. 102 (22): 8060–5. Bibcode:2005PNAS..102.8060R. doi: 10.1073/pnas.0500825102 . PMC   1138258 . PMID   15911762.
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