ERG11

Last updated
Sterol 14-demethylase
Identifiers
Organism Saccharomyces cerevisiae
SymbolERG11
Alt. symbolsCYP51F1
Entrez 856398
HomoloGene 55488
RefSeq (mRNA) NM_001179137
RefSeq (Prot) NP_011871
UniProt P10614
Other data
EC number 1.14.14.154
Chromosome VIII: 0.12 - 0.12 Mb
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Structures Swiss-model
Domains InterPro

ERG11 or sterol 14-demethylase is a fungal cytochrome P450 enzyme originally from Saccharomyces cerevisiae , belongs to family CYP51, with the CYP Symbol CYP51F1. [1] ERG11 catalyzes the C14-demethylation of lanosterol to 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol which is the first step of biosynthesis of the zymosterol, zymosterol will be further converted into ergosterol. [2]

References

  1. ↑ Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. (October 2003). "Global analysis of protein expression in yeast". Nature. 425 (6959): 737–41. Bibcode:2003Natur.425..737G. doi:10.1038/nature02046. PMID   14562106. S2CID   4344864.
  2. ↑ Mo C, Bard M (September 2005). "Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex". Journal of Lipid Research. 46 (9): 1991–8. doi: 10.1194/jlr.M500153-JLR200 . PMID   15995173.
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