Pentalenene oxygenase

Pentalenene oxygenase
Identifiers
EC no.	1.14.15.32
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Pentalenene oxygenase (EC 1.14.15.32, Formerly EC 1.14.13.133, PtlI) is an enzyme with systematic name pentalenene,NADPH:oxygen 13-oxidoreductase. ^[1] This enzyme catalyses the following chemical reaction

pentalenene + 2 NADPH + 2 H⁺ + 2 O₂${\displaystyle \rightleftharpoons }$ pentalen-13-al + 2 NADP⁺ + 3 H₂O (overall reaction)

(1a) pentalenene + NADPH + H⁺ + O₂${\displaystyle \rightleftharpoons }$ pentalen-13-ol + NADP⁺ + H₂O

(1b) pentalen-13-ol + NADPH + H⁺ + O₂${\displaystyle \rightleftharpoons }$ pentalen-13-al + NADP⁺ + 2 H₂O

Pentalenene oxygenase is a heme-thiolate protein (P-450).

References

1. Quaderer R, Omura S, Ikeda H, Cane DE (October 2006). "Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis". Journal of the American Chemical Society. 128 (40): 13036–7. Bibcode:2006JAChS.12813036Q. doi:10.1021/ja0639214. PMC   2533730 . PMID   17017767.

External links

• Pentalenene+oxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)