CYP305M2

Last updated
Identifiers
Organism Locusta migratoria
SymbolCYP305M2
UniProt A0A410UD22
Other data
EC number 1.14.-.-
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Structures Swiss-model
Domains InterPro

CYP305M2 (formerly called LM16181) is a cytochrome P450 enzyme found in migratory locust (Locusta migratoria) that catalyzes the key step of biosynthesis of phenylacetonitrile (PAN). [1] [2] PAN in turn is used as an aposematic chemical defense against predators.

Biosynthesis of phenylacetonitrile catalyzed by CYP305M2 and subsequent decomposition to benzaldehyde and cyanide Phenylacetonitrile biosynthesis.svg
Biosynthesis of phenylacetonitrile catalyzed by CYP305M2 and subsequent decomposition to benzaldehyde and cyanide

References

  1. Wei J, Shao W, Cao M, Ge J, Yang P, Chen L, Wang X, Kang L (January 2019). "Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor". Science Advances. 5 (1) eaav5495. Bibcode:2019SciA....5.5495W. doi:10.1126/sciadv.aav5495. PMC   6357733 . PMID   30746481.
  2. "Cytochrome P450 [Locusta migratoria]". NCBI Protein. National Center for Biotechnology Information, U.S. National Library of Medicine.