CYP3A7

CYP3A7
Identifiers
Aliases	CYP3A7 , CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, cytochrome P450 family 3 subfamily A member 7, P450HLp2
External IDs	OMIM: 605340; MGI: 88610; HomoloGene: 133564; GeneCards: CYP3A7; OMA:CYP3A7 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q22.1 Start 99,705,036 bp [1] End 99,735,196 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 G2|5 76.89 cM Start 137,891,194 bp [2] End 137,919,881 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell liver right lobe of liver testicle gonad kidney tubule gallbladder jejunal mucosa duodenum metanephric glomerulus Top expressed in duodenum jejunum ileum left lobe of liver intestinal villus epithelium of small intestine epithelium of stomach left colon mucous cell of stomach gallbladder More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen aromatase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen iron ion binding oxidoreductase activity heme binding oxygen binding metal ion binding steroid hydroxylase activity estrogen 16-alpha-hydroxylase activity monooxygenase activity estrogen 2-hydroxylase activity Cellular component endoplasmic reticulum membrane organelle membrane intracellular membrane-bounded organelle membrane endoplasmic reticulum Biological process xenobiotic metabolic process lipid hydroxylation steroid metabolic process estrogen metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1551 13113 Ensembl ENSG00000160870 ENSMUSG00000029727 UniProt P24462 Q64464 RefSeq (mRNA) NM_000765 NM_007819 RefSeq (protein) NP_000756 NP_031845 Location (UCSC) Chr 7: 99.71 – 99.74 Mb Chr 5: 137.89 – 137.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults. ^[5] The gene location is 7q22.1. ^[6]

The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals. ^[7]

The CYP3A7 enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The CYP3A7 gene is part of a cluster of related genes on chromosome 7q21.1. Naturally occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene. ^[8]

Notable alleles

The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000160870 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029727 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. doi:10.1093/oxfordjournals.jbchem.a122632. PMID   2722762.
6. "Cytochrome P450, Subfamily IIIA, Polypeptide 7". OMIM. Retrieved March 14, 2013.
7. Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics. 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID   10898111.
8.  This article incorporates public domain material from "CYP3A7 cytochrome P450 family 3 subfamily A member 7 [ Homo sapiens (human) ]". Reference Sequence collection . National Center for Biotechnology Information.
9. "CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer". Archived from the original on 2016-06-16. Retrieved 2016-03-27.

External links

• CYP3A7 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CYP3A7 genome location and CYP3A7 gene details page in the UCSC Genome Browser .