CYP3A7

Last updated
CYP3A7
Identifiers
Aliases CYP3A7 , CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, cytochrome P450 family 3 subfamily A member 7, P450HLp2
External IDs OMIM: 605340 MGI: 88610 HomoloGene: 133564 GeneCards: CYP3A7
Orthologs
SpeciesHumanMouse
Entrez

1551

13113

Ensembl

ENSG00000160870

ENSMUSG00000029727

UniProt

P24462

Q64464

RefSeq (mRNA)

NM_000765

NM_007819

RefSeq (protein)

NP_000756

NP_031845

Location (UCSC) Chr 7: 99.71 – 99.74 Mb Chr 5: 137.89 – 137.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults. [5] The gene location is 7q22.1. [6]

Contents

The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals. [7]

The CYP3A7 enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The CYP3A7 gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene. [8]

Notable alleles

The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents. [9]

Related Research Articles

<span class="mw-page-title-main">CYP2E1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2E1 is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown of foreign compounds in mammals.

<span class="mw-page-title-main">CYP2A6</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2A6 is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.

<span class="mw-page-title-main">CYP1A2</span> Enzyme in the human body

Cytochrome P450 1A2, a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene.

<span class="mw-page-title-main">CYP1B1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 1B1 is an enzyme that in humans is encoded by the CYP1B1 gene.

<span class="mw-page-title-main">CYP3A5</span> Enzyme involved in drug metabolism

Cytochrome P450 3A5 is a protein that in humans is encoded by the CYP3A5 gene.

<span class="mw-page-title-main">CYP4B1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1 gene.

<span class="mw-page-title-main">CYP26A1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 26A1 is a protein that in humans is encoded by the CYP26A1 gene.

<span class="mw-page-title-main">CYP2A13</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene.

<span class="mw-page-title-main">CYP3A43</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.

<span class="mw-page-title-main">CYP2F1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2F1 is a protein that in humans is encoded by the CYP2F1 gene.

<span class="mw-page-title-main">CYP26B1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 26B1 is a protein that in humans is encoded by the CYP26B1 gene.

<span class="mw-page-title-main">CYP39A1</span> Protein-coding gene in the species Homo sapiens

CYP39A1 also known as oxysterol 7-α-hydroxylase 2 is a protein that in humans is encoded by the CYP39A1 gene.

<span class="mw-page-title-main">CYP26C1</span> Protein-coding gene in the species Homo sapiens

CYP26C1 is a protein which in humans is encoded by the CYP26C1gene.

<span class="mw-page-title-main">CYP20A1</span> Protein-coding gene in the species Homo sapiens

CYP20A1 is a protein which in humans is encoded by the CYP20A1 gene.

<span class="mw-page-title-main">CYP8B1</span> Protein-coding gene in the species Homo sapiens

CYP8B1 also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP8B1 gene.

<span class="mw-page-title-main">CYP4X1</span> Protein-coding gene in the species Homo sapiens

CYP4X1 is a protein which in humans is encoded by the CYP4X1 gene.

<span class="mw-page-title-main">CYP4F11</span> Protein-coding gene in the species Homo sapiens

CYP4F11 is a protein that in humans is encoded by the CYP4F11 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

<span class="mw-page-title-main">CYP4A22</span> Protein-coding gene in the species Homo sapiens

CYP4A22 also known as fatty acid omega-hydroxylase is a protein which in humans is encoded by the CYP4A22 gene.

<span class="mw-page-title-main">CYP2W1</span> Protein-coding gene in the species Homo sapiens

CYP2W1 is a protein that in humans is encoded by the CYP2W1 gene.

<span class="mw-page-title-main">CYP2A7</span> Protein-coding gene in the species Homo sapiens

CYP2A7 is a protein that in humans is encoded by the CYP2A7 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160870 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029727 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. doi:10.1093/oxfordjournals.jbchem.a122632. PMID   2722762.
  6. ↑ "Cytochrome P450, Subfamily IIIA, Polypeptide 7". OMIM. Retrieved March 14, 2013.
  7. ↑ Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics. 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID   10898111.
  8. ↑ PD-icon.svg This article incorporates public domain material from "CYP3A7 cytochrome P450 family 3 subfamily A member 7 [ Homo sapiens (human) ]". Reference Sequence collection . National Center for Biotechnology Information.
  9. ↑ "CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer". Archived from the original on 2016-06-16. Retrieved 2016-03-27.


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