CYP11C1

Last updated
cytochrome P450, family 11, subfamily c, polypeptide 1
Identifiers
Organism Danio rerio
SymbolCYP11C1
Entrez 791124
HomoloGene 128035
RefSeq (mRNA) NM_001080204.1
RefSeq (Prot) NP_001073673.1
UniProt A1XRK1
Other data
EC number 1.14.15.4
Chromosome 16: 54.46 - 54.48 Mb
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Structures Swiss-model
Domains InterPro

The Cyp11c1 is a fish gene encoding a CYP450 enzyme, which was originally found in Zebrafish (Danio rerio), this enzyme mainly catalyze the formation of cortisol and 11-Ketotestosterone (11-KT). [1] 11-KT is the endogenous androgen in zebrafish. [2] CYP11C is the orthologous to CYP11B, tetrapod's CYP11B1 evolved from CYP11C1 of fish, and CYP11B/11C are the ohnologues to CYP11A, which duplicated during 2R event. [3]

References

  1. ↑ Zhang Q, Ye D, Wang H, Wang Y, Hu W, Sun Y (June 2020). "Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction". Endocrinology. 161 (6). doi: 10.1210/endocr/bqaa048 . PMID   32222764. S2CID   214716321.
  2. ↑ Zheng Q, Xiao H, Shi H, Wang T, Sun L, Tao W, et al. (March 2020). "Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone". The Journal of Endocrinology. 244 (3): 487–499. doi: 10.1530/JOE-19-0438 . PMID   31910154.
  3. ↑ Nelson DR, Goldstone JV, Stegeman JJ (February 2013). "The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368 (1612) 20120474. doi:10.1098/rstb.2012.0474. PMC   3538424 . PMID   23297357.
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