CYP11C1

Last updated
cytochrome P450, family 11, subfamily c, polypeptide 1
Identifiers
Organism Danio rerio
SymbolCYP11C1
Entrez 791124
HomoloGene 128035
RefSeq (mRNA) NM_001080204.1
RefSeq (Prot) NP_001073673.1
UniProt A1XRK1
Other data
EC number 1.14.15.4
Chromosome 16: 54.46 - 54.48 Mb
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Structures Swiss-model
Domains InterPro

The Cyp11c1 is a fish gene encoding a CYP450 enzyme, which was originally found in Zebrafish (Danio rerio), this enzyme mainly catalyze the formation of cortisol and 11-Ketotestosterone (11-KT). [1] 11-KT is the endogenous androgen in zebrafish. [2] CYP11C is the orthologous to CYP11B, tetrapod's CYP11B1 evolved from CYP11C1 of fish, and CYP11B/11C are the ohnologues to CYP11A, which duplicated during 2R event. [3]

References

  1. Zhang Q, Ye D, Wang H, Wang Y, Hu W, Sun Y (June 2020). "Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction". Endocrinology. 161 (6). doi: 10.1210/endocr/bqaa048 . PMID   32222764. S2CID   214716321.
  2. Zheng Q, Xiao H, Shi H, Wang T, Sun L, Tao W, et al. (March 2020). "Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone". The Journal of Endocrinology. 244 (3): 487–499. doi: 10.1530/JOE-19-0438 . PMID   31910154.
  3. Nelson DR, Goldstone JV, Stegeman JJ (February 2013). "The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368 (1612) 20120474. doi:10.1098/rstb.2012.0474. PMC   3538424 . PMID   23297357.