CYP2A7

CYP2A7
Identifiers
Aliases	CYP2A7 , CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4, cytochrome P450 family 2 subfamily A member 7
External IDs	OMIM: 608054 MGI: 88597 HomoloGene: 85917 GeneCards: CYP2A7
Gene location (Mouse) Chr. Chromosome 7 (mouse) [1] Band 7 A3|7 15.54 cM Start 26,534,730 bp [1] End 26,542,973 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver vagina myometrium sural nerve stromal cell of endometrium canal of the cervix right lung corpus callosum superior frontal gyrus Top expressed in proximal tubule kidney hepatobiliary system liver esophagus respiratory epithelium thymus olfactory epithelium lung ovary More reference expression data BioGPS n/a
Gene ontology Molecular function monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen aromatase activity heme binding metal ion binding iron ion binding oxidoreductase activity oxygen binding arachidonic acid epoxygenase activity steroid hydroxylase activity Cellular component membrane intracellular membrane-bounded organelle endoplasmic reticulum membrane organelle membrane endoplasmic reticulum cytoplasm Biological process epoxygenase P450 pathway organic acid metabolic process xenobiotic metabolic process coumarin metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1549 13087 Ensembl n/a ENSMUSG00000005547 UniProt P20853 P20852 RefSeq (mRNA) NM_000764 NM_030589 NM_007812 RefSeq (protein) NP_000755 NP_085079 n/a Location (UCSC) n/a Chr 7: 26.53 – 26.54 Mb PubMed search [2] [3]
Wikidata
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CYP2A7 (cytochrome P450, family 2, subfamily A, polypeptide 7) is a protein that in humans is encoded by the CYP2A7 gene. ^{[4] [5]}

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. ^[6]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000005547 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR (September 1995). "A Genetic Polymorphism in Coumarin 7-Hydroxylation: Sequence of the Human CYP2A Gnes and Identification of Variant CYP2A6 Alleles". Am. J. Hum. Genet. 57 (3): 651–60. PMC   1801261 . PMID   7668294.
5. Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (January 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID   15128046.
6.  This article incorporates public domain material from "Entrez Gene: CYP2A7". Reference Sequence collection . National Center for Biotechnology Information.

External links

• Human CYP2A7 genome location and CYP2A7 gene details page in the UCSC Genome Browser .

Further reading

• Smith BD, Sanders JL, Porubsky PR, et al. (2007). "Structure of the human lung cytochrome P450 2A13". J. Biol. Chem. 282 (23): 17306–13. doi: 10.1074/jbc.M702361200 . PMID   17428784.
• Wang HH, Liao YW, Chiang HL, et al. (2009). "Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population". Pharmacogenomics. 10 (3): 359–74. doi:10.2217/14622416.10.3.359. PMID   19290787.
• Fernandez-Salguero P, Gonzalez FJ (1995). "The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis". Pharmacogenetics. 5 (Special Issue): S123–8. doi:10.1097/00008571-199512001-00013. PMID   7581481.
• Cauffiez C, Lo-Guidice JM, Quaranta S, et al. (2004). "Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility". Biochem. Biophys. Res. Commun. 317 (2): 662–9. doi:10.1016/j.bbrc.2004.03.092. PMID   15063809.
• Timofeeva MN, Kropp S, Sauter W, et al. (2009). "CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences". Carcinogenesis. 30 (7): 1161–9. doi: 10.1093/carcin/bgp102 . PMID   19414505.
• Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID   9890157.
• Saito A, Kawamoto M, Kamatani N (2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". J. Hum. Genet. 54 (6): 317–23. doi: 10.1038/jhg.2009.31 . PMID   19343046.
• He XY, Shen J, Ding X, et al. (2004). "Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen". Drug Metab. Dispos. 32 (12): 1516–21. doi:10.1124/dmd.104.001370. PMID   15333516. S2CID   26225467.
• Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID   15128046.
• He XY, Shen J, Hu WY, et al. (2004). "Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation". Arch. Biochem. Biophys. 427 (2): 143–53. doi:10.1016/j.abb.2004.03.016. PMID   15196988.
• Herr D, Bettendorf H, Denschlag D, et al. (2006). "Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma". Arch. Gynecol. Obstet. 274 (6): 367–71. doi:10.1007/s00404-006-0201-8. PMID   16835796. S2CID   28342598.
• Song DK, Xing DL, Zhang LR, et al. (2009). "Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China". Cancer Detect. Prev. 32 (5–6): 416–23. doi:10.1016/j.cdp.2009.02.003. PMID   19303722.
• Fujieda M, Yamazaki H, Kiyotani K, et al. (2003). "Eighteen novel polymorphisms of the CYP2A13 gene in Japanese". Drug Metab. Pharmacokinet. 18 (1): 86–90. doi:10.2133/dmpk.18.86. PMID   15618722.
• Wang H, Tan W, Hao B, et al. (2003). "Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK". Cancer Res. 63 (22): 8057–61. PMID   14633739.
• Cheng XY, Chen GL, Zhang WX, et al. (2004). "Arg257Cys polymorphism of CYP2A13 in a Chinese population". Clin. Chim. Acta. 343 (1–2): 213–6. doi:10.1016/j.cccn.2004.01.017. PMID   15115698.
• D'Agostino J, Zhang X, Wu H, et al. (2008). "Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidence of lung adenocarcinoma in smokers". Drug Metab. Dispos. 36 (11): 2316–23. doi:10.1124/dmd.108.022822. PMC   2597635 . PMID   18669584.
• Cauffiez C, Pottier N, Tournel G, et al. (2005). "CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations". Xenobiotica. 35 (7): 661–9. doi:10.1080/00498250500202171. PMID   16316926. S2CID   39901230.
• Mohelnikova-Duchonova B, Vrana D, Holcatova I, et al. (2010). "CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk". Pancreas. 39 (2): 144–8. doi:10.1097/MPA.0b013e3181bab6c2. PMID   19812523. S2CID   25113289.
• Jiang JH, Jia WH, Chen HK, et al. (2004). "Genetic polymorphisms of CYP2A13 and its relationship to nasopharyngeal carcinoma in the Cantonese population". J Transl Med. 2 (1): 24. doi: 10.1186/1479-5876-2-24 . PMC   455696 . PMID   15222883.
• Young RP, Hopkins RJ, Hay BA, et al. (2009). "A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers". Postgrad Med J. 85 (1008): 515–24. doi: 10.1136/pgmj.2008.077107 . PMID   19789190.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.