Beta-amyrin 11-oxidase

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Beta-amyrin 11-oxidase
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EC no. 1.14.13.134
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Beta-amyrin 11-oxidase (EC 1.14.13.134, CYP88D6) is an enzyme with systematic name beta-amyrin,NADPH:oxygen oxidoreductase (hydroxylating). [1] This enzyme catalyses the following chemical reaction

beta-amyrin + 2 O2 + 2 NADPH + 2 H+ 11-oxo-beta-amyrin + 3 H2O + 2 NADP+ (overall reaction)
(1a) beta-amyrin + O2 + NADPH + H+ 11alpha-hydroxy-beta-amyrin + H2O + NADP+
(1b) 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ 11-oxo-beta-amyrin + 2 H2O + NADP+

Beta-amyrin 11-oxidase requires cytochrome P450.

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References

  1. ↑ Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T (September 2008). "Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin". Proceedings of the National Academy of Sciences of the United States of America. 105 (37): 14204–9. Bibcode:2008PNAS..10514204S. doi: 10.1073/pnas.0803876105 . PMC   2532699 . PMID   18779566.
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