Nitric oxide reductase (NAD(P), nitrous oxide-forming)

Nitric oxide reductase (NAD(P), nitrous oxide-forming)
Identifiers
EC no.	1.7.1.14
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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Nitric oxide reductase (NAD(P), nitrous oxide-forming) (EC 1.7.1.14, fungal nitric oxide reductase, cytochrome P450nor, NOR (ambiguous)) is an enzyme with systematic name nitrous oxide:NAD(P) oxidoreductase. ^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

N₂O + NAD(P)⁺ + H
_²O${\displaystyle \rightleftharpoons }$ 2 NO + NAD(P)H + H⁺

This enzyme is heme-thiolate protein (P450).

References

1. Shoun H, Tanimoto T (June 1991). "Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 in the respiratory nitrite reduction". The Journal of Biological Chemistry. 266 (17): 11078–82. doi: 10.1016/S0021-9258(18)99130-1 . PMID   2040619.
2. Shiro Y, Fujii M, Iizuka T, Adachi S, Tsukamoto K, Nakahara K, Shoun H (January 1995). "Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide. Implication for its nitric oxide reduction mechanism". The Journal of Biological Chemistry. 270 (4): 1617–23. doi: 10.1074/jbc.270.4.1617 . PMID   7829493.
3. Zhang L, Kudo T, Takaya N, Shoun H (September 2002). "The B' helix determines cytochrome P450nor specificity for the electron donors NADH and NADPH". The Journal of Biological Chemistry. 277 (37): 33842–7. doi: 10.1074/jbc.M203923200 . PMID   12105197.
4. Oshima R, Fushinobu S, Su F, Zhang L, Takaya N, Shoun H (September 2004). "Structural evidence for direct hydride transfer from NADH to cytochrome P450nor". Journal of Molecular Biology. 342 (1): 207–17. doi:10.1016/j.jmb.2004.07.009. PMID   15313618.

External links

• Nitric+oxide+reductase+(NAD(P),+nitrous+oxide-forming) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)