Pentalenolactone synthase

Pentalenolactone synthase
Identifiers
EC no.	1.14.19.8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Pentalenolactone synthase (EC 1.14.19.8, Formerly EC 1.3.7.10, penM (gene), pntM (gene)) is an enzyme with systematic name pentalenolactone-F:oxidized-ferredoxin oxidoreductase (pentalenolactone forming). It catalyses the rearrangement reaction

pentalenolactone F

+ 2 H⁺ + 2 reduced
ferredoxin

 

 

O₂

2 H₂O

O₂

2 H₂O

 

pentalenolactone

+ 2 oxidised
ferredoxin

 

This is heme-thiolate protein (P-450), which is isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae .The transformation is the final step in the biosynthesis of pentalenolactone. ^{[1] [2] [3]}

References

1. Enzyme 1.14.19.8 at KEGG Pathway Database.
2. Cane, David E.; Oliver, John S.; Harrison, Paul H. M.; Abell, Christopher; Hubbard, Brian R.; Kane, Charles T.; Lattman, Rene (1990). "Biosynthesis of pentalenene and pentalenolactone". Journal of the American Chemical Society. 112 (11): 4513–4524. doi:10.1021/ja00167a059.
3. Zhu D, Seo MJ, Ikeda H, Cane DE (February 2011). "Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone". Journal of the American Chemical Society. 133 (7): 2128–31. Bibcode:2011JAChS.133.2128Z. doi:10.1021/ja111279h. PMC   3041837 . PMID   21284395.

External links

• Pentalenolactone+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)