Ent-isokaurene C2-hydroxylase

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Ent-isokaurene C2-hydroxylase
Identifiers
EC no. 1.14.13.143
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Ent-isokaurene C2-hydroxylase (EC 1.14.13.143, CYP71Z6) is an enzyme with systematic name ent-isokaurene,NADPH:oxygen oxidoreductase (hydroxylating). [1] This enzyme catalyses the following chemical reaction

ent-isokaurene + O2 + NADPH + H+ ent-2alpha-hydroxyisokaurene + H2O + NADP+

Ent-isokaurene C2-hydroxylase performs the initial step in the conversion of ent-isokaurene to the antibacterial oryzalides in rice, Oryza sativa .

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References

  1. ↑ Wu Y, Hillwig ML, Wang Q, Peters RJ (November 2011). "Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7". FEBS Letters. 585 (21): 3446–51. doi:10.1016/j.febslet.2011.09.038. PMC   3227696 . PMID   21985968.


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