CYP76 family

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Cytochrome P450, family 76, also known as CYP76, is a cytochrome P450 family in land plants, [1] [2] related to the biosynthesis of many plant monoterpenes and diterpenes such as 8-hydroxygeraniol, [3] [2] tanshinone and alkannin. [4] [5] The first gene identified in this family is the CYP76A1 and CYP76A2 from the eggplant. [1]

References

  1. 1 2 Toguri, T; Kobayashi, O; Umemoto, N (19 October 1993). "The cloning of eggplant seedling cDNAs encoding proteins from a novel cytochrome P-450 family (CYP76)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1216 (1): 165–9. doi:10.1016/0167-4781(93)90058-l. PMID   8218411.
  2. 1 2 Höfer, R; Dong, L; André, F; Ginglinger, JF; Lugan, R; Gavira, C; Grec, S; Lang, G; Memelink, J; Van der Krol, S; Bouwmeester, H; Werck-Reichhart, D (November 2013). "Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway". Metabolic Engineering. 20: 221–32. doi:10.1016/j.ymben.2013.08.001. PMID   23933465.
  3. ↑ Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J (November 2001). "Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis". FEBS Letters. 508 (2): 215–20. doi: 10.1016/s0014-5793(01)03045-9 . PMID   11718718. S2CID   45615763.
  4. ↑ Höfer, R; Boachon, B; Renault, H; Gavira, C; Miesch, L; Iglesias, J; Ginglinger, JF; Allouche, L; Miesch, M; Grec, S; Larbat, R; Werck-Reichhart, D (November 2014). "Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides". Plant Physiology. 166 (3): 1149–61. doi:10.1104/pp.114.244814. PMC   4226383 . PMID   25082892.
  5. ↑ Bathe, Ulschan; Frolov, Andrej; Porzel, Andrea; Tissier, Alain (11 December 2019). "CYP76 Oxidation Network of Abietane Diterpenes in Lamiaceae Reconstituted in Yeast". Journal of Agricultural and Food Chemistry. 67 (49): 13437–13450. Bibcode:2019JAFC...6713437B. doi:10.1021/ACS.JAFC.9B00714. PMID   30994346.
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