CYP3A43

Last updated
CYP3A43
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CYP3A43 , cytochrome P450 family 3 subfamily A member 43
External IDs OMIM: 606534 HomoloGene: 136124 GeneCards: CYP3A43
EC number 1.14.14.56
Orthologs
SpeciesHumanMouse
Entrez

64816

n/a

Ensembl

ENSG00000021461

n/a

UniProt

Q9HB55

n/a

RefSeq (mRNA)

NM_001278921
NM_022820
NM_057095
NM_057096

n/a

RefSeq (protein)

NP_001265850
NP_073731
NP_476436
NP_476437

n/a

Location (UCSC) Chr 7: 99.83 – 99.87 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene. [3] [4] [5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [5]

Related Research Articles

<span class="mw-page-title-main">CYP2A6</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2A6 is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.

<span class="mw-page-title-main">CYP2C8</span> Gene-coded protein involved in metabolism of xenobiotics

Cytochrome P4502C8 (CYP2C8) is a member of the cytochrome P450 mixed-function oxidase system involved in the metabolism of xenobiotics in the body. Cytochrome P4502C8 also possesses epoxygenase activity, i.e. it metabolizes long-chain polyunsaturated fatty acids, e.g. arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and Linoleic acid to their biologically active epoxides.

<span class="mw-page-title-main">CYP1B1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 1B1 is an enzyme that in humans is encoded by the CYP1B1 gene.

<span class="mw-page-title-main">Prostacyclin synthase</span>

Prostaglandin-I synthase also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. This enzyme belongs to the family of cytochrome P450 isomerases.

<span class="mw-page-title-main">CYP3A5</span> Enzyme involved in drug metabolism

Cytochrome P450 3A5 is a protein that in humans is encoded by the CYP3A5 gene.

<span class="mw-page-title-main">CYP2C18</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2C18 is a protein that in humans is encoded by the CYP2C18 gene.

<span class="mw-page-title-main">CYP4B1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1 gene.

<span class="mw-page-title-main">Flavin containing monooxygenase 1</span> Protein-coding gene in the species Homo sapiens

Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that in humans is encoded by the FMO1 gene.

Cytochrome P450, family 3, subfamily A, also known as CYP3A, is a human gene locus. A homologous locus is found in mice.

<span class="mw-page-title-main">FMO5</span> Protein-coding gene in the species Homo sapiens

Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme that in humans is encoded by the FMO5 gene.

<span class="mw-page-title-main">CYP2A13</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene.

<span class="mw-page-title-main">CYP2F1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2F1 is a protein that in humans is encoded by the CYP2F1 gene.

<span class="mw-page-title-main">CYP26B1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 26B1 is a protein that in humans is encoded by the CYP26B1 gene.

<span class="mw-page-title-main">CYP39A1</span> Protein-coding gene in the species Homo sapiens

CYP39A1 also known as oxysterol 7-α-hydroxylase 2 is a protein that in humans is encoded by the CYP39A1 gene.

<span class="mw-page-title-main">CYP26C1</span> Protein-coding gene in the species Homo sapiens

CYP26C1 is a protein which in humans is encoded by the CYP26C1gene.

<span class="mw-page-title-main">CYP20A1</span> Protein-coding gene in the species Homo sapiens

CYP20A1 is a protein which in humans is encoded by the CYP20A1 gene.

<span class="mw-page-title-main">CYP8B1</span> Protein-coding gene in the species Homo sapiens

CYP8B1 also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP8B1 gene.

<span class="mw-page-title-main">CYP4X1</span> Protein-coding gene in the species Homo sapiens

CYP4X1 is a protein which in humans is encoded by the CYP4X1 gene.

<span class="mw-page-title-main">CYP2W1</span> Protein-coding gene in the species Homo sapiens

CYP2W1 is a protein that in humans is encoded by the CYP2W1 gene.

<span class="mw-page-title-main">CYP2A7</span> Protein-coding gene in the species Homo sapiens

CYP2A7 is a protein that in humans is encoded by the CYP2A7 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000021461 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG (Feb 2001). "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450". Mol Pharmacol. 59 (2): 386–92. doi:10.1124/mol.59.2.386. PMID   11160876.
  4. ↑ Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L (Mar 2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene". Pharmacogenetics. 11 (2): 111–21. doi:10.1097/00008571-200103000-00002. PMID   11266076.
  5. 1 2 "Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43".

Further reading


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