CYP26C1

Last updated
CYP26C1
Identifiers
Aliases CYP26C1 , FFDD4, cytochrome P450 family 26 subfamily C member 1
External IDs OMIM: 608428 MGI: 2679699 HomoloGene: 28089 GeneCards: CYP26C1
Orthologs
SpeciesHumanMouse
Entrez

340665

546726

Ensembl

ENSG00000187553

ENSMUSG00000062432

UniProt

Q6V0L0

B2RXA7

RefSeq (mRNA)

NM_183374

NM_001105201

RefSeq (protein)

NP_899230

NP_001098671

Location (UCSC) Chr 10: 93.06 – 93.07 Mb Chr 19: 37.67 – 37.68 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CYP26C1 (cytochrome P450, family 26, subfamily c, polypeptide 1) is a protein which in humans is encoded by the CYP26C1gene. [5]

Contents

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. [6]

CYP26C1 was found to show no expression in colorectal cancer cells or normal colonic epithelium. [7]

Related Research Articles

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CYP4F22 is a protein that in humans is encoded by the CYP4F22 gene.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000187553 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062432 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Taimi M, Helvig C, Wisniewski J, et al. (January 2004). "A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid". J. Biol. Chem. 279 (1): 77–85. doi: 10.1074/jbc.M308337200 . PMID   14532297.
  6. ↑ PD-icon.svg This article incorporates public domain material from "Entrez Gene: CYP26C1". Reference Sequence collection . National Center for Biotechnology Information.
  7. ↑ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. 9 (3): e90776. Bibcode:2014PLoSO...990776B. doi: 10.1371/journal.pone.0090776 . PMC   3946526 . PMID   24608339.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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