CYP4X1

CYP4X1
Identifiers
Aliases	CYP4X1 , CYPIVX1, cytochrome P450 family 4 subfamily X member 1
External IDs	OMIM: 614999 MGI: 1932403 HomoloGene: 75853 GeneCards: CYP4X1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p33|1 Start 47,023,669 bp [1] End 47,050,751 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D1 Start 114,963,520 bp [2] End 114,991,478 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva trachea bronchial epithelial cell Brodmann area 23 urethra endothelial cell right coronary artery minor salivary gland ascending aorta trigeminal ganglion Top expressed in facial motor nucleus substantia nigra trigeminal ganglion piriform cortex dorsomedial hypothalamic nucleus medial dorsal nucleus anterior horn of spinal cord medial geniculate nucleus temporal lobe cingulate gyrus More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 260293 81906 Ensembl ENSG00000186377 ENSMUSG00000047155 UniProt Q8N118 Q6A152 RefSeq (mRNA) NM_178033 NM_001320289 NM_001320290 NM_001003947 RefSeq (protein) NP_001307218 NP_001307219 NP_828847 NP_001003947 Location (UCSC) Chr 1: 47.02 – 47.05 Mb Chr 4: 114.96 – 114.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) is a protein which in humans is encoded by the CYP4X1 gene. ^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000186377 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047155 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bylund J; Zhang C; Harder DR (August 2002). "Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain". Biochem. Biophys. Res. Commun. 296 (3): 677–84. doi:10.1016/S0006-291X(02)00918-X. PMID   12176035.
6.  This article incorporates public domain material from "Entrez Gene: CYP4X1". Reference Sequence collection . National Center for Biotechnology Information.

Further reading

• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Savas U, Hsu MH, Griffin KJ, et al. (2005). "Conditional regulation of the human CYP4X1 and CYP4Z1 genes". Arch. Biochem. Biophys. 436 (2): 377–85. doi:10.1016/j.abb.2005.02.022. PMID   15797250.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID   15128046.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.