Amorpha-4,11-diene 12-monooxygenase

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Amorpha-4,11-diene 12-monooxygenase
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EC no. 1.14.13.158
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Amorpha-4,11-diene 12-monooxygenase (EC 1.14.13.158, CYP71AV1) is an enzyme with systematic name amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating). [1] This enzyme catalyses the following chemical reaction

amorpha-4,11-diene + 3 O2 + 3 NADPH + 3 H+ artemisinate + 3 NADP+ + 4 H2O (overall reaction)
(1a) amorpha-4,11-diene + O2 + NADPH + H+ artemisinic alcohol + NADP+ + H2O
(1b) artemisinic alcohol + O2 + NADPH + H+ artemisinic aldehyde + NADP+ + 2 H2O
(1c) artemisinic aldehyde + O2 + NADPH + H+ artemisinate + NADP+ + H2O

Amorpha-4,11-diene 12-monooxygenase is a heme-thiolate protein (P-450)

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References

  1. ↑ Teoh KH, Polichuk DR, Reed DW, Nowak G, Covello PS (February 2006). "Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin". FEBS Letters. 580 (5): 1411–6. doi: 10.1016/j.febslet.2006.01.065 . PMID   16458889.
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