CYP20A1

Last updated
CYP20A1
Identifiers
Aliases CYP20A1 , CYP-M, cytochrome P450 family 20 subfamily A member 1
External IDs MGI: 1925201 HomoloGene: 18584 GeneCards: CYP20A1
Orthologs
SpeciesHumanMouse
Entrez

57404

77951

Ensembl

ENSG00000119004

ENSMUSG00000049439

UniProt

Q6UW02

Q8BKE6

RefSeq (mRNA)

NM_020674
NM_177538

NM_030013
NM_001313721

RefSeq (protein)

NP_001300650
NP_084289

Location (UCSC) Chr 2: 203.24 – 203.31 Mb Chr 1: 60.38 – 60.43 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein which in humans is encoded by the CYP20A1 gene. [5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in pollutant and drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP20A1 lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [6]

CYP20A1 has no identified substrate or biological role and is considered an "orphan" P450.

Related Research Articles

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Cytochrome P450 2A6 is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.

<span class="mw-page-title-main">CYP1A2</span> Enzyme in the human body

Cytochrome P450 1A2, a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene.

<span class="mw-page-title-main">CYP1B1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 1B1 is an enzyme that in humans is encoded by the CYP1B1 gene.

<span class="mw-page-title-main">21-Hydroxylase</span> Human enzyme that hydroxylates steroids

Steroid 21-hydroxylase is an enzyme that hydroxylates steroids at the C21 position and is involved in biosynthesis of aldosterone and cortisol. The enzyme converts progesterone and 17α-hydroxyprogesterone into 11-deoxycorticosterone and 11-deoxycortisol, respectively, within metabolic pathways that ultimately lead to aldosterone and cortisol. Deficiency in the enzyme may cause congenital adrenal hyperplasia.

<span class="mw-page-title-main">Steroid 11β-hydroxylase</span> Protein found in mammals

Steroid 11β-hydroxylase, also known as steroid 11β-monooxygenase, is a steroid hydroxylase found in the zona glomerulosa and zona fasciculata of the adrenal cortex. Named officially the cytochrome P450 11B1, mitochondrial, it is a protein that in humans is encoded by the CYP11B1 gene. The enzyme is involved in the biosynthesis of adrenal corticosteroids by catalyzing the addition of hydroxyl groups during oxidation reactions.

<span class="mw-page-title-main">CYP2C18</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2C18 is a protein that in humans is encoded by the CYP2C18 gene.

<span class="mw-page-title-main">CYP4B1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1 gene.

<span class="mw-page-title-main">CYP2A13</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene.

<span class="mw-page-title-main">CYP3A43</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.

<span class="mw-page-title-main">CYP2F1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 2F1 is a protein that in humans is encoded by the CYP2F1 gene.

<span class="mw-page-title-main">CYP4F12</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 4F12 is a protein that in humans is encoded by the CYP4F12 gene.

<span class="mw-page-title-main">CYP26B1</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 26B1 is a protein that in humans is encoded by the CYP26B1 gene.

<span class="mw-page-title-main">CYP39A1</span> Protein-coding gene in the species Homo sapiens

CYP39A1 also known as oxysterol 7-α-hydroxylase 2 is a protein that in humans is encoded by the CYP39A1 gene.

<span class="mw-page-title-main">CYP26C1</span> Protein-coding gene in the species Homo sapiens

CYP26C1 is a protein which in humans is encoded by the CYP26C1gene.

<span class="mw-page-title-main">CYP8B1</span> Protein-coding gene in the species Homo sapiens

CYP8B1 also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP8B1 gene.

<span class="mw-page-title-main">CYP4X1</span> Protein-coding gene in the species Homo sapiens

CYP4X1 is a protein which in humans is encoded by the CYP4X1 gene.

<span class="mw-page-title-main">CYP4F22</span> Protein-coding gene in the species Homo sapiens

CYP4F22 is a protein that in humans is encoded by the CYP4F22 gene.

<span class="mw-page-title-main">CYP2W1</span> Protein-coding gene in the species Homo sapiens

CYP2W1 is a protein that in humans is encoded by the CYP2W1 gene.

<span class="mw-page-title-main">CYP2U1</span> Protein-coding gene in the species Homo sapiens

CYP2U1 is a protein that in humans is encoded by the CYP2U1 gene

<span class="mw-page-title-main">CYP2A7</span> Protein-coding gene in the species Homo sapiens

CYP2A7 is a protein that in humans is encoded by the CYP2A7 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000119004 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049439 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
  6. ↑ PD-icon.svg This article incorporates public domain material from "Entrez Gene: CY20A1". Reference Sequence collection . National Center for Biotechnology Information.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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