CYP2A13

Last updated
CYP2A13
Protein CYP2A13 PDB 1z10.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CYP2A13 , CPAD, CYP2A, CYPIIA13, cytochrome P450 family 2 subfamily A member 13
External IDs OMIM: 608055 MGI: 88597 HomoloGene: 85917 GeneCards: CYP2A13
Gene location (Human)
Ideogram human chromosome 19.svg
Chr. Chromosome 19 (human) [1]
Human chromosome 19 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 19q13.2Start41,088,451 bp [1]
End41,096,195 bp [1]
RNA expression pattern
PBB GE CYP2A13 207718 x at fs.png

PBB GE CYP2A13 208327 at fs.png

PBB GE CYP2A13 211295 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1553

13087

Ensembl

ENSG00000197838

n/a

UniProt

Q16696

P20852

RefSeq (mRNA)

NM_000766

NM_007812

RefSeq (protein)

NP_000757

n/a

Location (UCSC) Chr 19: 41.09 – 41.1 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene. [4] [5] [6]

Contents

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [6]

Related Research Articles

CYP2A6 protein-coding gene in the species Homo sapiens

Cytochrome P450 2A6 is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.

NNK chemical compound

Nicotine-derived nitrosamine ketone (NNK) is one of the key tobacco-specific nitrosamines derived from nicotine. It plays an important role in carcinogenesis. The conversion of nicotine to NNK entails opening of the pyrrolidine ring.

CYP2C9 mammalian protein found in Homo sapiens

Cytochrome P450 2C9 is an enzyme that in humans is encoded by the CYP2C9 gene.

CYP2C19 protein-coding gene in the species Homo sapiens

Cytochrome P450 2C19 is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This subfamily includes enzymes that catalize metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs. In humans, it is the CYP2C19 gene that encodes the CYP2C19 protein. CYP2C19 is a liver enzyme that acts on at least 10% of drugs in current clinical use, most notably the antiplatelet treatment clopidogrel (Plavix), drugs that treat pain associated with ulcers, such as omeprazole, antiseizure drugs such as mephenytoin, the antimalarial proguanil, and the anxiolytic diazepam.

CYP1A1 Protein-coding gene in the species Homo sapiens

Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the CYP1A1 gene. The protein is a member of the cytochrome P450 superfamily of enzymes.

CYP1B1 protein-coding gene in the species Homo sapiens

Cytochrome P450 1B1 is an enzyme that in humans is encoded by the CYP1B1 gene.

Prostacyclin synthase mammalian protein found in Homo sapiens

Prostaglandin-I synthase also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. This enzyme belongs to the family of cytochrome P450 isomerases.

CYP3A5 protein-coding gene in the species Homo sapiens

Cytochrome P450 3A5 is a protein that in humans is encoded by the CYP3A5 gene.

CYP2J2 gene of the species Homo sapiens

Cytochrome P450 2J2 (CYP2J2) is a protein that in humans is encoded by the CYP2J2 gene. CYP2J2 is a member of the cytochrome P450 superfamily of enzymes. The enzymes are oxygenases which catalyze many reactions involved in the metabolism of drugs and other xenobiotics) as well as in the synthesis of cholesterol, steroids and other lipids.

CYP4B1 protein-coding gene in the species Homo sapiens

Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1 gene.

CYP4F2 protein-coding gene in the species Homo sapiens

Leukotriene-B(4) omega-hydroxylase 1 is an enzyme involved in the metabolism various endogenous substrates and xenobiotics. Most notable substrate of the enzyme is leukotriene B4, a potent mediator of inflammation. The enzyme is encoded by the CYP4F2 gene in humans.

CYP3A43 protein-coding gene in the species Homo sapiens

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.

CYP2F1 protein-coding gene in the species Homo sapiens

Cytochrome P450 2F1 is a protein that in humans is encoded by the CYP2F1 gene.

CYP39A1 protein-coding gene in the species Homo sapiens

CYP39A1 also known as oxysterol 7-α-hydroxylase 2 is a protein that in humans is encoded by the CYP39A1 gene.

CYP26C1 protein-coding gene in the species Homo sapiens

CYP26C1 is a protein which in humans is encoded by the CYP26C1gene.

CYP20A1 protein-coding gene in the species Homo sapiens

CYP20A1 is a protein which in humans is encoded by the CYP20A1 gene.

CYP8B1 protein-coding gene in the species Homo sapiens

CYP8B1 also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP8B1 gene.

CYP4X1 protein-coding gene in the species Homo sapiens

CYP4X1 is a protein which in humans is encoded by the CYP4X1 gene.

CYP2W1 protein-coding gene in the species Homo sapiens

CYP2W1 is a protein that in humans is encoded by the CYP2W1 gene.

CYP2A7 protein-coding gene in the species Homo sapiens

CYP2A7 is a protein that in humans is encoded by the CYP2A7 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000197838 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR, et al. (Oct 1995). "A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles". Am J Hum Genet. 57 (3): 651–60. PMC   1801261 . PMID   7668294.
  5. ↑ Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (May 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID   15128046.
  6. 1 2 "Entrez Gene: CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13".

Further reading


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