Dan Barouch

Last updated
Dan Barouch
Dan Barouch 20191016 07.jpg
Dan Barouch in 2019
Born(1973-02-04)February 4, 1973 [1]
CitizenshipAmerican
EducationM.D. and Ph.D.
Alma materHarvard and Oxford
Spouse(s)Fina C. Barouch, M.D.
ChildrenSusanna and Natalie
Scientific career
Fields Virology
Institutions Beth Israel Deaconess Medical Center Harvard Medical School, Ragon Institute MIT and Harvard [3]

Dan Hung Barouch is an American physician, immunologist, and virologist. He is known for his work on the pathogenesis and immunology of viral infections and the development of vaccine strategies for global infectious diseases. His research led to the development of vaccine candidates for HIV, Zika, influenza, tuberculosis, monkeypox, and COVID-19, including the Johnson & Johnson COVID-19 vaccine [4] [5] [6] [7] . He was named the founding director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, and is a founding member and a steering committee member at the Ragon Institute [8] .

Contents

Barouch is Director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center [9] and the William Bosworth Castle Professor of Medicine at Harvard Medical School [10] . He is also affiliated with the Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery [11] .

Barouch has authored over 400 original peer-reviewed research articles and 50 review articles on infectious diseases, viral pathogenesis, immune responses, and vaccine development [12] [13] [14] . He was elected to the National Academy of Medicine in 2020 [15] [16] [17] and received the King Faisal Prize in Medicine in 2023 for his work [18] .

Early Life and Education

Barouch grew up in Potsdam, New York, in an academic family with his mother, a biochemist; his father, a professor of mathematics and computer science; and his sister, now a cardiologist [19] .

He attended Harvard College at the age of 16. Barouch received his B.A. in biochemistry from Harvard University summa cum laude at the age of 20 in 1993. In 1995, at the age of 22, he received his Ph.D. in immunology from Oxford University as a Marshall Scholar [20] .

A scholar and a violinist [21] [22] , Barouch's time at Oxford University under the mentorship of Sir Andrew McMichael shaped his interests in virology and immunology. Barouch returned to Boston in 1995 and attended Havard Medical School.

In 1999, he received his M.D. from Harvard Medical School with highest honors summa cum laude. He completed clinical residency training in internal medicine and fellowship training in infectious diseases at Massachusetts General Hospital and Brigham and Women's Hospital in Boston. [23]

In 2002, he established his independent research laboratory at age 29 at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston [24] .

Personal Life

Barouch is married to Fina C. Barouch, M.D., an ophthalmologist and vitreoretinal surgeon [25] . They have two daughters, Susanna and Natalie, and reside in Newton, Massachusetts.

Research and Career

Barouch is a professor of medicine and professor of immunology at Harvard Medical School. [26] In 2012, he was named the founding director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center in Boston. [27] [28] He is also a founding member and a steering committee member at the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University. [29] [30] He was appointed the William Bosworth Castle Professor of Medicine at Harvard Medical School in 2020 [31] .


HIV research

Barouch started to develop vaccine candidates against HIV and other infectious diseases while in graduate school and medical school. He launched his independent research laboratory at age 29. His early work involved the creation of vaccine platform technologies, including adjuvanted DNA vaccines and novel adenoviral vectors, including Ad26 [32] [33] [34] .

In 2000, while still in medical school, Barouch started researching the development of an HIV vaccine. [35] He reported that HIV vaccines reduced viral loads in preclinical studies but that viral escape from immune responses could undermine immune control [36] . In 2002, he published that a candidate HIV vaccine can suppress the virus in preclinical studies for a period of two years. [37] In 2006, he developed adenovirus vaccine vectors that evaded suppression by baseline vector immunity. [38] [39] His research provided the scientific foundation for the Johnson & Johnson HIV vaccine candidate, including the creation of a set of "mosaic" proteins with Bette Korber, which improve immune responses against multiple strains of the virus. [29] [40]

Barouch was promoted to Professor of Medicine at Harvard Medical School in 2010. Two years later, in 2012, he became the Founding Director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center [41] .

From 2015 to 2018, Barouch co-led the HIV-V-0004 APPROACH study, testing the mosaic Ad26/Env vaccine in human subjects. [42] This vaccine was then advanced into clinical efficacy trials in Africa, North America, South America, and Europe with the National Institutes of Health, the Bill & Melinda Gates Foundation, Janssen, and others. [29] [43]

Barouch has also worked on immunologic strategies to cure HIV infection. [44] In 2016 and 2018, he demonstrated the potential of combining therapeutic vaccines or broadly neutralizing antibodies with immune activators, also known as the "shock and kill" strategy. [45] Barouch has also discussed his research and has commented on the research of others in the media. [46]

Zika research

In 2016, Barouch developed and tested the first Zika vaccines in preclinical studies. [47] [48] These vaccines entered first-in-human trials later that year. [49]

COVID-19 research

In February 2021, Barouch co-authored a paper on how a certain level of COVID-19 antibodies may provide lasting protection against the virus. [50] [51]

Societies and awards

In 2009, Barouch was elected to the American Society for Clinical Investigation. [52]

In 2013, he became a member of the Association of American Physicians. [23]

In 2016, Barouch was named honorary researcher at the centre de Recherche, Centre hospitalier de l'Université de Montréal [53] and was named a Bostonian of the Year by the Boston Globe Magazine . [47]

In 2017, Barouch was named the Investigator of the Year by the Massachusetts Society for Medical Research and received the Drexel Prize in Immunology from the Drexel University College of Medicine.[ citation needed ]

In 2019, Barouch received the Best Academic Research Team Vaccine Industry Excellence Award at the World Vaccine Congress. [23]

In 2020 he was elected to the National Academy of Medicine.

In 2021, he was awarded the George Ledlie Prize for his work towards the creation of the SARS-CoV-2 vaccine, [54] and was awarded the Bostonians of the Year Award by The Boston Globe. [55]

In 2023, he was jointly awarded the 2023 King Faisal Prize for Medicine with vaccinologist Sarah Gilbert. [56] [57]

Related Research Articles

<span class="mw-page-title-main">David Baltimore</span> American biologist (born 1938)

David Baltimore is an American biologist, university administrator, and 1975 Nobel laureate in Physiology or Medicine. He is a professor of biology at the California Institute of Technology (Caltech), where he served as president from 1997 to 2006. He founded the Whitehead Institute and directed it from 1982 to 1990. In 2008, he served as president of the American Association for the Advancement of Science.

Alvaro Pascual-Leone is a Spanish-American Professor of neurology at Harvard Medical School, with which he has been affiliated since 1997. He is currently a Senior Scientist at the Hinda and Arthur Marcus Institute for Aging Research at Hebrew SeniorLife. He was previously the Director of the Berenson-Allen Center for Noninvasive Brain Stimulation and Program Director of the Harvard-Thorndike Clinical Research Center of the Beth Israel Deaconess Medical Center in Boston.

<span class="mw-page-title-main">Beth Israel Deaconess Medical Center</span> Hospital in Boston, Massachusetts, US

Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts is a teaching hospital of Harvard Medical School and one of the founding members of Beth Israel Lahey Health. It was formed out of the 1996 merger of Beth Israel Hospital and New England Deaconess Hospital. Among independent teaching hospitals, Beth Israel Deaconess Medical Center has ranked in the top three recipients of biomedical research funding from the National Institutes of Health. Research funding totals nearly $200 million annually. BIDMC researchers run more than 850 active sponsored projects and 200 clinical trials. The Harvard-Thorndike General Clinical Research Center, the oldest clinical research laboratory in the United States, has been located on this site since 1973.

<span class="mw-page-title-main">Pier Paolo Pandolfi</span> Italian cancer geneticist

Pier Paolo Pandolfi is an Italian doctor, geneticist, molecular biologist, and cancer researcher.

Josef E. Fischer (1937–2021) was an American surgeon, scientist, and professor at Harvard Medical School.

<span class="mw-page-title-main">Jaap Goudsmit</span>

Jaap Goudsmit is a Dutch scientist, known for his research in the field of AIDS and influenza. He shifted his research interest to aging and neurodegenerative diseases, like Alzheimer's Disease. He is also a prolific writer of non-fiction books: Viral Sex, the Nature of AIDS (1997); Viral Fitness, the Next SARS and West Nile in the Making (2004); Serendipity Manual (2012); The Vaccine Bug, a personal history of the World of Immunity (2013); Immorbidity Alphabet, Spelling-out a life free of dis-ease (2015); The Time of your Life, Staying healthy to the End (2016) and The Art of Facing Mortality, a scientist's view (2016).

Thumbi Ndung’u is a Kenyan-born HIV/AIDS researcher. He is the deputy director (Science) and a Max Planck Research Group Leader at the Africa Health Research Institute (AHRI) in Durban, South Africa. He is Professor of Infectious Diseases in the Division of Immunity and Infection, University College London. He is Professor and Victor Daitz Chair in HIV/TB Research and Scientific Director of the HIV Pathogenesis Programme (HPP) at the Nelson R. Mandela School of Medicine, University of KwaZulu-Natal. He holds the South African Research Chair in Systems Biology of HIV/AIDS. He is an adjunct professor of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health. He is the Programme Director of the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE), a research and capacity building initiative funded by the African Academy of Sciences and the Wellcome Trust.

<span class="mw-page-title-main">Stephen C. Harrison</span> American chemist and pharmacologist

Stephen C. Harrison is professor of biological chemistry and molecular pharmacology, professor of pediatrics, and director of the Center for Molecular and Cellular Dynamics of Harvard Medical School, head of the Laboratory of Molecular Medicine at Boston Children's Hospital, and investigator of the Howard Hughes Medical Institute.

Mitchell T. Rabkin is an American physician and Distinguished Institute Scholar at the Shapiro Institute, Professor of Medicine at Harvard Medical School and CEO Emeritus at the Beth Israel Deaconess Medical Center.

Mary Katharine Levinge Collins, Lady Hunt is a British Professor of virology and the director of the Queen Mary University of London Blizard Institute. She served as Provost at the Okinawa Institute of Science and Technology in Japan. Formerly, Collins taught in the Division of Infection and Immunity at University College London, and was the head of the Division of Advanced Therapies at the National Institute for Biological Standards and Control, and the Director of the Medical Research Council Centre for Medical Molecular Virology. Her research group studies the use of viruses as vectors for introducing new genes into cells, which can be useful for experimental cell biology, for clinical applications such as gene therapy, and as cancer vaccines.

Gary J. Nabel is an American virologist and immunologist who is President and chief executive officer of ModeX Therapeutics in Natick, Massachusetts. He was the founding director of Vaccine Research Center at the National Institute of Allergy and Infectious Diseases.

<span class="mw-page-title-main">Igor J. Koralnik</span>

Igor Koralnik is an American physician, neurologist and scientist. He is one of the first physicians to study the neurologic complications caused by the human immunodeficiency virus (HIV) and is a leading researcher in the investigation of the polyomavirus JC, which causes progressive multifocal leukoencephalopathy (PML), a disease of the central nervous system that occurs in immunosuppressed individuals.

A Zika virus vaccine is designed to prevent the symptoms and complications of Zika virus infection in humans. As Zika virus infection of pregnant women may result in congenital defects in the newborn, the vaccine will attempt to protect against congenital Zika syndrome during the current or any future outbreak. As of April 2019, no vaccines have been approved for clinical use, however a number of vaccines are currently in clinical trials. The goal of a Zika virus vaccine is to produce specific antibodies against the Zika virus to prevent infection and severe disease. The challenges in developing a safe and effective vaccine include limiting side effects such as Guillain-Barré syndrome, a potential consequence of Zika virus infection. Additionally, as dengue virus is closely related to Zika virus, the vaccine needs to minimize the possibility of antibody-dependent enhancement of dengue virus infection.

<span class="mw-page-title-main">Andrew McMichael</span>

Sir Andrew James McMichael, is an immunologist, Professor of Molecular Medicine, and previously Director of the Weatherall Institute of Molecular Medicine at the University of Oxford. He is particularly known for his work on T cell responses to viral infections such as influenza and HIV.

<span class="mw-page-title-main">Hendrik Streeck</span> German virologist

Hendrik Streeck is a German researcher of human immunodeficiency virus, epidemiologist and clinical trialist. He is professor of virology and the director of the Institute of Virology and HIV Research at the University Bonn.

Barbara B. Kahn is an endocrinologist and the George Richards Minot professor of medicine at Harvard Medical School. She is also the vice chair for research strategy in the department of medicine at Beth Israel Deaconess Medical Center, and was formerly the chief of the Division of Endocrinology, Diabetes, and Metabolism at Beth Israel Deaconess. Her research focuses on insulin resistance and type 2 diabetes.

Marylyn Martina Addo is a German infectiologist who is a Professor and the German Center for Infection Research (DZIF) Head of Infectious Disease at the University Medical Center Hamburg-Eppendorf. Addo has developed and tested vaccinations that protect people from Ebola virus disease and the MERS coronavirus EMC/2012. She is currently developing a viral vector based COVID-19 vaccine.

<span class="mw-page-title-main">George Tsokos</span> Professor of Medicine at Harvard Medical School

George C. Tsokos is a Greek-American rheumatologist who serves as a Professor of Medicine at Harvard Medical School and the Chief of the Division of Rheumatology and Clinical Immunology at the Beth Israel Deaconess Medical Center, Boston. He is recognized as one of the foremost leaders of modern lupus research with landmark discoveries that have brought understanding of lupus to new levels, shedding light on how the disease develops and progresses over time.

<span class="mw-page-title-main">Viral vector vaccine</span> Type of vaccine

A viral vector vaccine is a vaccine that uses a viral vector to deliver genetic material (DNA) that can be transcribed by the recipient's host cells as mRNA coding for a desired protein, or antigen, to elicit an immune response. As of April 2021, six viral vector vaccines, four COVID-19 vaccines and two Ebola vaccines, have been authorized for use in humans.

Michael S. Diamond is a biomedical researcher, physician-scientist specializing in virology and immunology, with a particular emphasis on emerging RNA viruses such as flaviviruses, alphaviruses, and coronaviruses. He is a professor at Washington University School of Medicine, where he holds the Herbert S. Gasser Professorship of Medicine.

References

  1. "Professor Dan Hung Barouch – King Faisal Prize" . Retrieved 2024-11-14.
  2. "Professor Dan Hung Barouch – King Faisal Prize" . Retrieved 2024-11-14.
  3. "Dan H. Barouch, M.D., Ph.D." 2019-11-04. Retrieved 2024-10-28.
  4. "Barouch Laboratory – Center for Virology and Vaccine Research (CVVR)". 4 November 2019.
  5. "Dan Barouch receives Ledlie Prize for vaccine work". 6 August 2021.
  6. "414 days at work, zero days off: Dan Barouch and the race to develop the Johnson & Johnson vaccine - the Boston Globe". The Boston Globe .
  7. "Zika Vaccine Development Reveals Differences in Efficacy One Year on | Harvard Magazine". 13 December 2017.
  8. https://ragoninstitute.org/
  9. https://www.bidmc.org/about-bidmc/news/2020/10/barouch-named-to-nam
  10. "Dan H. Barouch, M.D., Ph.D." 4 November 2019.
  11. "Dan Barouch, MD, PhD | UCSF-Bay Area Center for AIDS Research (CFAR)".
  12. https://pubmed.ncbi.nlm.nih.gov/?term=%28%28%28Barouch%2C+Dan%5BAuthor%5D%29+OR+%28Barouch%2C+Dan+H%5BAuthor%5D%29%29+OR+%28Barouch+DH%5BAuthor%5D%29%29+OR+%28Barouch%2C+Dh%5BAuthor%5D%29&sort=
  13. "Dan Barouch | Harvard Catalyst Profiles | Harvard Catalyst".
  14. "ORCID".
  15. "National Academy of Medicine Elects New Members | Harvard Magazine". 22 October 2020.
  16. "Dan Hung Barouch | Harvard Program in Virology".
  17. https://nam.edu/national-academy-of-medicine-elects-100-new-members-2020/
  18. "Professor Dan Hung Barouch – King Faisal Foundation".
  19. "Jews in the News: Mark Bomback, Judy Blume and Dan Barouch | Tampa JCCS and Federation".
  20. "Dan Barouch".
  21. Quick, Jonathan D.; Fryer, Bronwyn (30 January 2018). The End of Epidemics: The Looming Threat to Humanity and How to Stop It. St. Martin's Publishing. ISBN   978-1-250-11778-6.
  22. "Dan Barouch".
  23. 1 2 3 "biography". Center for Virology and Vaccine Research. Archived from the original on 2019-10-03. Retrieved 2019-10-03.
  24. https://www.bidmc.org/research/research-by-department/medicine/center-for-virology-and-vaccine-research/barouch-laboratory
  25. "Fina Barouch, MD - Lahey Health".
  26. Browning, Bil (July 12, 2019). "A new vaccine for HIV that would work worldwide is expanding human testing to America". www.lgbtqnation.com.
  27. "Dr. Dan Barouch to lead Beth Israel Deaconess center for vaccine research - The Boston Globe". BostonGlobe.com.
  28. "Novel HIV vaccine candidate is safe and induces immune response in healthy adults and monkeys". ScienceDaily.
  29. 1 2 3 "HIV Vaccine Takes Big Step | Harvard Medical School". hms.harvard.edu. December 2017.
  30. "Monoclonal antibodies show promise as effective HIV therapy". medicalxpress.com.
  31. "Dan Hung Barouch | PhD Program in Immunology".
  32. Quick, Jonathan D.; Fryer, Bronwyn (30 January 2018). The End of Epidemics: The Looming Threat to Humanity and How to Stop It. St. Martin's Publishing. ISBN   978-1-250-11778-6.
  33. Abbink, P.; Lemckert, A. A.; Ewald, B. A.; Lynch, D. M.; Denholtz, M.; Smits, S.; Holterman, L.; Damen, I.; Vogels, R.; Thorner, A. R.; O'Brien, K. L.; Carville, A.; Mansfield, K. G.; Goudsmit, J.; Havenga, M. J.; Barouch, D. H. (2007). "Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D". Journal of Virology. 81 (9): 4654–4663. doi:10.1128/JVI.02696-06. PMC   1900173 . PMID   17329340.
  34. Quick, Dr Jonathan D.; Fryer, Bronwyn (January 30, 2018). The End of Epidemics: The Looming Threat to Humanity and How to Stop It. St. Martin's Publishing Group. ISBN   9781250117786 via Google Books.
  35. Singhal, Arvind; Rogers, Everett M.; Rogers, Dr Everett M. (October 3, 2003). Combating AIDS: Communication Strategies in Action. SAGE. ISBN   9780761997283 via Google Books.
  36. Barouch, D. H.; Kunstman, J.; Kuroda, M. J.; Schmitz, J. E.; Santra, S.; Peyerl, F. W.; Krivulka, G. R.; Beaudry, K.; Lifton, M. A.; Gorgone, D. A.; Montefiori, D. C.; Lewis, M. G.; Wolinsky, S. M.; Letvin, N. L. (2002). "Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes". Nature. 415 (6869): 335–339. doi:10.1038/415335a. PMID   11797012.
  37. "HIV Plus". Plus. Here Publishing: 11. ISSN   1522-3086 . Retrieved 2019-10-03.
  38. "The Finding". The Scientist. 2008. p. 63.
  39. Roberts, Diane M.; Nanda, Anjali; Havenga, Menzo J. E.; Abbink, Peter; Lynch, Diana M.; Ewald, Bonnie A.; Liu, Jinyan; Thorner, Anna R.; Swanson, Patricia E.; Gorgone, Darci A.; Lifton, Michelle A.; Lemckert, Angelique A. C.; Holterman, Lennart; Chen, Bing; Dilraj, Athmanundh; Carville, Angela; Mansfield, Keith G.; Goudsmit, Jaap; Barouch, Dan H. (2006). "Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity". Nature. 441 (7090): 239–243. Bibcode:2006Natur.441..239R. doi:10.1038/nature04721. PMID   16625206.
  40. Assunção, Muri (13 July 2019). "Johnson & Johnson to start testing on new type of HIV vaccine in U.S. and Europe". nydailynews.com.
  41. "Dr. Dan Barouch to lead Beth Israel Deaconess center for vaccine research - the Boston Globe". The Boston Globe .
  42. Karim, Quarraisha Abdool; Karim, Salim S. Abdool; Baxter, Cheryl (January 20, 2017). The CAPRISA Clinical Trials: HIV Treatment and Prevention. Springer. ISBN   9783319475189 via Google Books.
  43. Mega, Emiliano Rodríguez (July 31, 2019). "'Mosaic' HIV vaccine to be tested in thousands of people across the world". Nature. 572 (7768): 165–166. Bibcode:2019Natur.572..165M. doi: 10.1038/d41586-019-02319-8 . PMID   31388154.
  44. "World's second man cleared of AIDS virus invigorates quest for cure". Reuters. March 6, 2019 via www.reuters.com.
  45. "Monkeys reveal new clues toward elusive HIV vaccine and cure". Science | AAAS. March 9, 2018.
  46. "Promising HIV vaccine to be tested with gay men and trans people". aidsmap. 22 July 2019. Retrieved 2019-10-03.
  47. 1 2 "Dan Barouch and Jim Collins: The researchers racing to stop Zika - The Boston Globe". BostonGlobe.com.
  48. Mukherjee, Siddhartha (August 15, 2016). "The Race for a Zika Vaccine". The New Yorker via www.newyorker.com.
  49. Knapton, Sarah (August 4, 2016). "Zika vaccine gives complete protection and is ready for human trials, say scientists". The Telegraph via www.telegraph.co.uk.
  50. Krouse, Sarah (2021-02-21). "Elon Musk got 4,000 SpaceX workers to join a COVID-19 study. Here's what he learned". Wall Street Journal . Retrieved 2021-02-21 via foxbusiness.com.
  51. Bartsch, Yannic C.; Fischinger, Stephanie; Siddiqui, Sameed M.; Chen, Zhilin; Yu, Jingyou; Gebre, Makda; Atyeo, Caroline; Gorman, Matthew J.; Zhu, Alex Lee; Kang, Jaewon; Burke, John S.; Slein, Matthew; Gluck, Matthew J.; Beger, Samuel; Hu, Yiyuan; Rhee, Justin; Petersen, Eric; Mormann, Benjamin; de St Aubin, Michael; Hasdianda, Mohammad A.; Jambaulikar, Guruprasad; Boyer, Edward W.; Sabeti, Pardis C.; Barouch, Dan H.; Julg, Boris D.; Musk, Elon R.; Menon, Anil S.; Lauffenburger, Douglas A.; Nilles, Eric J.; Alter, Galit (2021-02-15). "Discrete SARS-CoV-2 antibody titers track with functional humoral stability". Nature Communications . 12 (1): 1018. Bibcode:2021NatCo..12.1018B. doi: 10.1038/s41467-021-21336-8 . PMC   7884400 . PMID   33589636.
  52. "The American Society for Clinical Investigation".
  53. "Barouch, Dan H. | CHUM". www.chumontreal.qc.ca.
  54. Parsons, Lian (2021-08-06). "Dan Barouch receives Ledlie Prize for vaccine work". Harvard Gazette. Retrieved 2024-10-28.
  55. "2021 Bostonians of the Year". 2021-12-16. Retrieved 2024-10-28.
  56. "Dan Barouch Awarded King Faisal Prize". Ragon Institute of Mass General, MIT, and Harvard. 6 January 2023. Retrieved 2024-11-14.
  57. "Professor Dan Hung Barouch – King Faisal Prize" . Retrieved 2024-11-14.