Author | Greg Bear |
---|---|
Language | English |
Series | Darwin series |
Genre | Science fiction novel |
Publisher | Del Rey |
Publication date | 31 August 1999 |
Publication place | United States |
Media type | Print (hardback & paperback) |
Pages | 448 |
ISBN | 0-345-42333-X |
OCLC | 40940104 |
813/.54 21 | |
LC Class | PS3552.E157 D43 1999 |
Followed by | Darwin's Children |
Darwin's Radio is a 1999 science fiction novel by Greg Bear. It won the Nebula Award in 2000 for Best Novel [1] [2] and the 2000 Endeavour Award. [3] It was also nominated for the Hugo Award, Locus and Campbell Awards the same year. [1]
The novel's original tagline was "The next great war will be inside us." It was followed by a sequel, Darwin's Children , in 2003.
In the novel, a new form of endogenous retrovirus has emerged, SHEVA. It controls human evolution by rapidly evolving the next generation while it is in the womb, leading to speciation.
The novel follows several characters as the "plague" is discovered as well as the panicked reaction of the public and the US government to the disease. [4]
Built into the human genome are non-coding sequences of DNA called introns. Certain portions of those "non-sense" sequences, remnants of prehistoric retroviruses, have been activated and are translating numerous LPCs (large protein complexes). The activation of SHEVA and its consequential sudden speciation was postulated to be controlled by a complex genetic network that perceives a need for modification or to be a human adaptive response to overcrowding. The disease, or rather, gene activation, is passed on laterally from male to female as per an STD. If impregnated, a woman in her first trimester who has contracted SHEVA will miscarry a deformed female fetus made of little more than two ovaries. This "first stage fetus" leaves behind a fertilized egg with 52 chromosomes, rather than the typical 46 characteristic of Homo sapiens sapiens .
During the third trimester of the second stage pregnancy, both parents go into a pre-speciation puberty to prepare them for the needs of their novel child. Facial pigmentation changes underneath the old skin which begins sloughing off like a mask. Vocal organs and olfactory glands alter and sensitize respectively, to adapt for a new form of communication. For over a year after the first SHEVA outbreak in the United States, no second stage fetus was recorded to have been born alive. The new human species was highly sensitive to all varieties of herpes and could not be viably born to a mother who had ever been infected with any of the virus's many forms, including Epstein-Barr and the chickenpox, thus eliminating 95% of the female population. Anesthetics and pitocin administered during childbirth were also lethal. So while many women would contract activated SHEVA that few would manage to give birth, making the transition from Homo sapiens sapiens to the new human species very gradual.
The international response to the threat of SHEVA was to form a special task force that would work alongside the Centers for Disease Control and Prevention (CDC) to find a vaccine. Because the "disease", called "Herod's Flu", was already in the genome of every person on Earth, the only two options were to inhibit the activation of the SHEVA gene by discovering the signal it used or to abort the second-stage fetus. Due to the rapid mutation rate of the missing-link signal molecule, preventing the activation of the gene was infeasible.
The second option, abortion, was already a controversial issue and the proposal of handing out free RU 486 was met with social upheaval, adding to the already-chaotic social scene. The general public believed that the government was not placing due importance on the death of countless fetuses or that it already had a cure and refused to release it. In response, government research facilities were forced to test prospective treatments prematurely and could not pursue explanations for SHEVA outside of the "disease" category because of the potential reactions from the masses. It was not until viable second-stage fetuses were born that the idea of SHEVA being a part of evolution rather than a disease began to grow from a few isolated sources.
The X chromosome is one of the two sex chromosomes in many organisms, including mammals, and is found in both males and females. It is a part of the XY sex-determination system and XO sex-determination system. The X chromosome was named for its unique properties by early researchers, which resulted in the naming of its counterpart Y chromosome, for the next letter in the alphabet, following its subsequent discovery.
The humanzee is a hypothetical hybrid of chimpanzee and human, thus a form of human–animal hybrid. Serious attempts to create such a hybrid were made by Soviet biologist Ilya Ivanovich Ivanov in the 1920s, and possibly by researchers in China in the 1960s, though neither succeeded.
Paleogenetics is the study of the past through the examination of preserved genetic material from the remains of ancient organisms. Emile Zuckerkandl and Linus Pauling introduced the term in 1963, long before the sequencing of DNA, in reference to the possible reconstruction of the corresponding polypeptide sequences of past organisms. The first sequence of ancient DNA, isolated from a museum specimen of the extinct quagga, was published in 1984 by a team led by Allan Wilson.
Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 3 spans more than 198 million base pairs and represents about 6.5 percent of the total DNA in cells.
Chromosome 4 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 4 spans more than 190 million base pairs and represents between 6 and 6.5 percent of the total DNA in cells.
Chromosome 9 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome, as they normally do with all chromosomes. Chromosome 9 spans about 138 million base pairs of nucleic acids and represents between 4.0 and 4.5% of the total DNA in cells.
Chromosome 10 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 10 spans about 134 million base pairs and represents between 4 and 4.5 percent of the total DNA in cells.
Chromosome 11 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome. Chromosome 11 spans about 135 million base pairs and represents between 4 and 4.5 percent of the total DNA in cells. The shorter arm is termed 11p while the longer arm is 11q. At about 21.5 genes per megabase, chromosome 11 is one of the most gene-rich, and disease-rich, chromosomes in the human genome.
Chromosome 12 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 12 spans about 133 million base pairs and represents between 4 and 4.5 percent of the total DNA in cells.
Chromosome 14 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 14 spans about 107 million base pairs and represents between 3 and 3.5% of the total DNA in cells.
Chromosome 17 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 17 spans more than 84 million base pairs and represents between 2.5 and 3% of the total DNA in cells.
Chromosome 18 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 18 spans about 80 million base pairs and represents about 2.5 percent of the total DNA in cells.
MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, macrophages, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses.
Pappalysin-1, also known as pregnancy-associated plasma protein A, and insulin-like growth factor binding protein-4 protease is a protein encoded by the PAPPA gene in humans. PAPPA is a secreted protease whose main substrate is insulin-like growth factor binding proteins. Pappalysin-1 is also used in screening tests for Down syndrome.
Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.
Zymogen Granule Protein 16 is a protein that is encoded by the ZG16 gene. Other common names include hZG16, FLJ43571, FLJ92276, secretory lectin ZG16, jacalin-like lectin domain containing, JCLN, JCLN1, MGC183567, MGC34820, ZG16A, zymogen granule membrane protein 16, zymogen granule protein 16 homolog, and zymogen granule protein. The gene is located on Chromosome 16: 29,778,256-29,782,973. The gene obtains one transcript and 128 orthologues.
Ankyrin repeat domain-containing protein 26 is a protein that in humans is encoded by the ANKRD26 gene. This protein has a function that is not currently understood.
Despeciation is the loss of a unique species of animal due to its combining with another previously distinct species. It is the opposite of speciation and is much more rare. It is similar to extinction in that there is a loss of a unique species but without the associated loss of a biological lineage. Despeciation has been noted in species of butterflies, sunflowers, mosquitoes, fish, wolves, and even humans.
Fibroblast growth factor receptor oncogene partner 2 (FGFR1OP2) was identified in a study on myeloproliferative syndrome (EMS). The study aimed to identify the partner genes to the fibroblast growth factor receptor 1 (FGFR1) involved in the syndrome. Using the 5'-RACE PCR technique, FGFR1OP2 was identified as a novel gene with no known function.
Ankyrin repeat domain-containing protein 24 is a protein in humans that is coded for by the ANKRD24 gene. The gene is also known as KIAA1981. The protein's function in humans is currently unknown. ANKRD24 is in the protein family that contains ankyrin-repeat domains.
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