David Siderovski | |
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Education |
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Awards | ASPET's John J. Abel Award in 2004 |
Scientific career | |
Fields | Biochemistry Pharmacology Neuroscience Medical education |
Institutions | Amgen Research Institute University of North Carolina at Chapel Hill West Virginia University University of North Texas Health Science Center |
Thesis | Human Immunodeficiency Virus Type-1 Trans-activator of Transcription (HIV-1 Tat) (1997) |
Doctoral advisor | Tak Wah Mak |
Other academic advisors | Alfred G. Gilman Robert J. Lefkowitz |
David Siderovski is a North American pharmacologist. [1] Since March 2020, Siderovski has been Chair of the HSC Department of Pharmacology & Neuroscience at the University of North Texas Health Science Center. [2] From 2012 to 2019, he was the E.J. Van Liere Medicine Professor and Chair of Physiology, Pharmacology & Neuroscience for the West Virginia University School of Medicine. [3]
Siderovski attended Earl Haig Secondary School in North York, Ontario, [4] graduating in 1985. [5] In 1989, Siderovski graduated with a BSc from Queen's University in Kingston, Ontario. [6]
Siderovski began his PhD training at the University of Toronto in May 1989. During his fifth year of his PhD, he began full-time work as a research scientist in the Quantitative Biology Laboratory of the Amgen Research Institute, Toronto. [7] He successfully defended his PhD thesis in November 1997. [8] He left the Amgen Research Institute in December 1998, having contributed to three patents as a co-inventor. [9] [10] [11]
After completing his industrial postdoctoral position at the Amgen Research Institute in 1998, [7] Siderovski joined the faculty at the University of North Carolina at Chapel Hill as an assistant professor of pharmacology. [12] His earliest publications discuss the RGS protein superfamily, [13] [14] [15] [16] and determinations of their varied protein structures [17] [18] [19] and cellular functions. [20] [ better source needed ]
In 2004, Siderovski was named the top American Pharmacologist under 40 and awarded the John J. Abel Award by the American Society for Pharmacology and Experimental Therapeutics. [21] [22] [ better source needed ]
From 2006 to 2012, Siderovski was the Thomas J. Dark Basic Science Director of UNC's Medical Scientist Training Program. [23] In August 2014, Siderovski was appointed Director of the West Virginia University School of Medicine MD/PhD Scholars Program. [24] Siderovski has been serving as Editorial Board Member for the Journal of Biological Chemistry since 2012. [25]
Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).
G protein-coupled receptor 35 also known as GPR35 is a G protein-coupled receptor which in humans is encoded by the GPR35 gene. Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.
Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.
Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.
Regulators of G protein signaling (RGS) are protein structural domains or the proteins that contain these domains, that function to activate the GTPase activity of heterotrimeric G-protein α-subunits.
GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.
1-Phosphatidylinositol-4,5-bisphosphate phospholipase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene.
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.
Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene.
Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.
Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.
Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene.
Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.
Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.
Marion Sewer (1972-2016) was a pharmacologist and professor at the University of California, San Diego's Skaggs School of Pharmacy and Pharmaceutical Sciences known for her research on steroid hormone biogenesis and her commitment to increasing diversity in science. Much of her research centered around cytochrome P450, a family of enzymes involved in the conversion of cholesterol into steroid hormones. She died unexpectedly at the age of 43 from a pulmonary embolism on January 28, 2016, while traveling through the Detroit airport.
Namandjé N. Bumpus is an American pharmacologist who serves as the Principal Deputy Commissioner and Acting Chief Scientist of the Food and Drug Administration. She was previously director of the department of pharmacology and molecular sciences at Johns Hopkins University School of Medicine, where she holds the E.K. Marshall and Thomas H. Maren professorship in pharmacology. Bumpus is known for her research on the metabolism of antiviral drugs used to treat HIV-1 and how genetic variations in drug-processing enzymes may impact these drugs' efficacy. Bumpus received a Presidential Early Career Award for Scientists and Engineers in 2016. The Food and Drug Administration’s top scientist Namandjé Bumpus has assumed the role of principal deputy commissioner when longtime agency leader Janet Woodcock retired from that role in January 2024.
Joan Heller Brown is an American pharmacologist. She is Distinguished Professor and Chair of the Department of Pharmacology at UC San Diego School of Medicine. She is known for fundamental contributions to the understanding of G-protein coupled receptors (GPCRs) — molecules that span cell membranes, where they transmit messages between cells and their environments — and how GPCRs regulate cell growth and survival, in healthy and various disease states. Many therapeutic drugs work by influencing GPCRs, thus Heller Brown's discoveries have been crucial to their development.
Paul Anthony Insel is an American physician and pharmacologist. He has been the chief editor of four academic journals and is an elected fellow of the American Association for the Advancement of Science, American Society for Pharmacology and Experimental Therapeutics, and American Physiological Society. His research is primarily focused on G proteins.
Lee Limbird is a pharmacologist, Dean of the School of Natural Science, Mathematics and Business & Professor in the Department of Life and Physical Sciences at Fisk University, Nashville, Tennessee.
Eva King Killam was a research pharmacologist who studied the activity of drugs on the brain and behavior, developing animal models for epilepsy and opiate dependence.