David Siderovski

Last updated
David Siderovski
David Siderovski on June 4th 2019.jpg
Education
AwardsASPET's John J. Abel Award in 2004
Scientific career
Fields Biochemistry
Pharmacology
Neuroscience
Medical education
Institutions Amgen Research Institute
University of North Carolina at Chapel Hill
West Virginia University
University of North Texas Health Science Center
Thesis Human Immunodeficiency Virus Type-1 Trans-activator of Transcription (HIV-1 Tat)  (1997)
Doctoral advisor Tak Wah Mak
Other academic advisors Alfred G. Gilman
Robert J. Lefkowitz

David Siderovski is a North American pharmacologist. [1] Since March 2020, Siderovski has been Chair of the HSC Department of Pharmacology & Neuroscience at the University of North Texas Health Science Center. [2] From 2012 to 2019, he was the E.J. Van Liere Medicine Professor and Chair of Physiology, Pharmacology & Neuroscience for the West Virginia University School of Medicine. [3]

Contents

Education

Siderovski attended Earl Haig Secondary School in North York, Ontario, [4] graduating in 1985. [5] In 1989, Siderovski graduated with a BSc from Queen's University in Kingston, Ontario. [6]

Siderovski began his PhD training at the University of Toronto in May 1989. During his fifth year of his PhD, he began full-time work as a research scientist in the Quantitative Biology Laboratory of the Amgen Research Institute, Toronto. [7] He successfully defended his PhD thesis in November 1997. [8] He left the Amgen Research Institute in December 1998, having contributed to three patents as a co-inventor. [9] [10] [11]

Career

After completing his industrial postdoctoral position at the Amgen Research Institute in 1998, [7] Siderovski joined the faculty at the University of North Carolina at Chapel Hill as an assistant professor of pharmacology. [12] His earliest publications discuss the RGS protein superfamily, [13] [14] [15] [16] and determinations of their varied protein structures [17] [18] [19] and cellular functions. [20] [ better source needed ]

In 2004, Siderovski was named the top American Pharmacologist under 40 and awarded the John J. Abel Award by the American Society for Pharmacology and Experimental Therapeutics. [21] [22] [ better source needed ]

From 2006 to 2012, Siderovski was the Thomas J. Dark Basic Science Director of UNC's Medical Scientist Training Program. [23] In August 2014, Siderovski was appointed Director of the West Virginia University School of Medicine MD/PhD Scholars Program. [24] Siderovski has been serving as Editorial Board Member for the Journal of Biological Chemistry since 2012. [25]

Related Research Articles

<span class="mw-page-title-main">RGS2</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).

<span class="mw-page-title-main">GPR35</span> G protein-coupled receptor

G protein-coupled receptor 35 also known as GPR35 is a G protein-coupled receptor which in humans is encoded by the GPR35 gene. Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.

<span class="mw-page-title-main">GNAI1</span> Protein-coding gene in humans

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.

<span class="mw-page-title-main">Neuropeptide Y receptor Y2</span> Protein-coding gene in the species Homo sapiens

Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.

<span class="mw-page-title-main">Regulator of G protein signaling</span>

Regulators of G protein signaling (RGS) are protein structural domains or the proteins that contain these domains, that function to activate the GTPase activity of heterotrimeric G-protein α-subunits.

<span class="mw-page-title-main">GGL domain</span>

GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.

<span class="mw-page-title-main">PLCB1</span> Protein-coding gene in the species Homo sapiens

1-Phosphatidylinositol-4,5-bisphosphate phospholipase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene.

<span class="mw-page-title-main">PLCB3</span> Protein-coding gene in the species Homo sapiens

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.

<span class="mw-page-title-main">RGS16</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene.

<span class="mw-page-title-main">GNB5</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

<span class="mw-page-title-main">RGS12</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.

<span class="mw-page-title-main">RGS14</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene.

<span class="mw-page-title-main">RGS6</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.

<span class="mw-page-title-main">RGS11</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.

Marion Sewer (1972-2016) was a pharmacologist and professor at the University of California, San Diego's Skaggs School of Pharmacy and Pharmaceutical Sciences known for her research on steroid hormone biogenesis and her commitment to increasing diversity in science. Much of her research centered around cytochrome P450, a family of enzymes involved in the conversion of cholesterol into steroid hormones. She died unexpectedly at the age of 43 from a pulmonary embolism on January 28, 2016, while traveling through the Detroit airport.

<span class="mw-page-title-main">Namandjé Bumpus</span> American pharmacologist

Namandjé N. Bumpus is an American pharmacologist who serves as the Principal Deputy Commissioner and Acting Chief Scientist of the Food and Drug Administration. She was previously director of the department of pharmacology and molecular sciences at Johns Hopkins University School of Medicine, where she holds the E.K. Marshall and Thomas H. Maren professorship in pharmacology. Bumpus is known for her research on the metabolism of antiviral drugs used to treat HIV-1 and how genetic variations in drug-processing enzymes may impact these drugs' efficacy. Bumpus received a Presidential Early Career Award for Scientists and Engineers in 2016. The Food and Drug Administration’s top scientist Namandjé Bumpus has assumed the role of principal deputy commissioner when longtime agency leader Janet Woodcock retired from that role in January 2024.

Joan Heller Brown is an American pharmacologist. She is Distinguished Professor and Chair of the Department of Pharmacology at UC San Diego School of Medicine. She is known for fundamental contributions to the understanding of G-protein coupled receptors (GPCRs) — molecules that span cell membranes, where they transmit messages between cells and their environments — and how GPCRs regulate cell growth and survival, in healthy and various disease states. Many therapeutic drugs work by influencing GPCRs, thus Heller Brown's discoveries have been crucial to their development.

Paul Anthony Insel is an American physician and pharmacologist. He has been the chief editor of four academic journals and is an elected fellow of the American Association for the Advancement of Science, American Society for Pharmacology and Experimental Therapeutics, and American Physiological Society. His research is primarily focused on G proteins.

Lee Limbird is a pharmacologist, Dean of the School of Natural Science, Mathematics and Business & Professor in the Department of Life and Physical Sciences at Fisk University, Nashville, Tennessee.

Eva King Killam was a research pharmacologist who studied the activity of drugs on the brain and behavior, developing animal models for epilepsy and opiate dependence.

References

  1. ↑ "Abel Numbers" (PDF). ASPET.org. May 30, 2019. Retrieved November 21, 2019.
  2. ↑ Joy, William (12 March 2020). "New COVID-19 treatment has helped dozens in China, UNTHSC researchers say". wfaa.com. WFAA (ABC Channel 8 Dallas, TX).
  3. ↑ Mcmurtrie, Beth (2017-10-01). "One University Takes On the Opioid Crisis". The Chronicle of Higher Education. ISSN   0009-5982 . Retrieved 2019-11-21.
  4. ↑ Gotlieb, Risha (9 Sep 1993). "School caters to bright kids". The Toronto Star. No. Page NY5. Torstar Syndication Services, a Division of Toronto Star Newspapers Limited. Retrieved 27 December 2021.
  5. ↑ Little, James (5 July 1985). "Two students who had 98.5 averages are both dubbed Metro's top students". The Toronto Star. Torstar Syndication Services, a Division of Toronto Star Newspapers Limited. ProQuest   1400913014 . Retrieved 27 December 2021.
  6. ↑ "Prince of Wales Prizes". Automatic Awards Open to All Upper Year Students. Queen's University. Archived from the original on 24 September 2015. Retrieved 11 August 2015.
  7. 1 2 "Can You Go Home Again? | The Scientist Magazine". The Scientist. Retrieved 2016-06-09.
  8. ↑ Siderovski, David Peter (1997). Human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat): Random mutagenesis and interaction with PKR (PDF). University of Toronto. Retrieved 2015-08-04.
  9. ↑ "Methods of modulating T-cell activation WO 1997041438 A1" . Retrieved 9 August 2015.
  10. ↑ "Apoptosis-inducing factor CA 2352467 A1" . Retrieved 9 August 2015.
  11. ↑ "Apoptosis-inducing factor CA 2352467 C" . Retrieved 9 August 2015.
  12. ↑ Lang, Leslie (25 March 2004). "UNC's Siderovski wins pharmacology award". EurekAlert!. Retrieved 28 December 2021.
  13. ↑ Roush, Wade (23 February 1996). "Regulating G Protein Signaling". Science. 271 (5252): 1056–1058. Bibcode:1996Sci...271.1056R. doi:10.1126/science.271.5252.1056. PMID   8599078. S2CID   83216123.
  14. ↑ Snow BE, Antonio L, Suggs S, Gutstein HB, Siderovski DP (April 1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochem Biophys Res Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID   9168931.
  15. ↑ Snow BE, Antonio L, Suggs S, Siderovski DP (January 1998). "Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene". Gene. 206 (2): 247–53. doi:10.1016/s0378-1119(97)00593-3. PMID   9469939.
  16. ↑ Siderovski DP, Strockbine B, Behe CI (1999). "Whither goest the RGS proteins?". Crit Rev Biochem Mol Biol. 34 (4): 215–51. doi:10.1080/10409239991209273. PMID   10517644.
  17. ↑ Davis, Molly (1 May 2007). "Picture-perfect Proteins". Endeavors.
  18. ↑ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (July 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi: 10.1074/jbc.273.28.17749 . PMID   9651375.
  19. ↑ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (October 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proceedings of the National Academy of Sciences of the United States of America . 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi: 10.1073/pnas.95.22.13307 . PMC   23793 . PMID   9789084.
  20. ↑ Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP, et al. (September 1998). "Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity". J Neurosci. 18 (18): 7178–88. doi:10.1523/JNEUROSCI.18-18-07178.1998. PMC   6793237 . PMID   9736641.
  21. ↑ "ASPET AWARD WINNERS FOR 2004" (PDF). The Pharmacologist. 46 (1): 3. March 2004. Retrieved 27 December 2021.
  22. ↑ Lang, Leslie (25 March 2004). "UNC's Siderovski wins pharmacology award". EurekAlert!. Retrieved 28 December 2021.
  23. ↑ "Leadership". UNC MD-PhD Program (circa March 24, 2012). Internet Archive Wayback Machine. Archived from the original on March 24, 2012. Retrieved 12 August 2015.
  24. ↑ "Siderovski Chosen to Oversee M.D./PH.D. Scholars Program". School of Medicine > Home > News > Story. WVU School of Medicine. 11 August 2014. Retrieved 13 August 2015.
  25. ↑ "JBC Editorial Board".
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