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Delirium is a specific state of acute confusion attributable to the direct physiological consequence of a medical condition, effects of a psychoactive substance, or multiple causes, which usually develops over the course of hours to days. As a syndrome, delirium presents with disturbances in attention, awareness, and higher-order cognition. People with delirium may experience other neuropsychiatric disturbances, including changes in psychomotor activity, disrupted sleep-wake cycle, emotional disturbances, disturbances of consciousness, or, altered state of consciousness, as well as perceptual disturbances, although these features are not required for diagnosis.
A TASER is a conducted energy device (CED) primarily used to incapacitate people, allowing them to be approached and handled in an unresisting and thus less-lethal manner. Sold by Axon, formerly TASER International, the TASER fires two small barbed darts intended to puncture the skin and remain attached to the target until removed by the user of the TASER device, at a speed of 55 m/s. Their range extends from 4.5 m (15 ft) for non-Law Enforcement Tasers to 10.5 m (34 ft) for Law Enforcement Tasers. The darts are connected to the main unit by thin laquer insulated copper wire and deliver a modulated electric current designed to disrupt voluntary control of muscles, causing "neuromuscular incapacitation." The effects of a taser may only be localized pain or strong involuntary long muscle contractions, based on the mode of use and connectivity of the darts.
Stimulant psychosis is a mental disorder characterized by psychotic symptoms. It involves and typically occurs following an overdose or several day binge on psychostimulants; however, one study reported occurrences at regularly prescribed doses in approximately 0.1% of individuals within the first several weeks after starting amphetamine or methylphenidate therapy. Methamphetamine psychosis, or long-term effects of stimulant use in the brain, depend upon genetics and may persist for some time.
Opioid use disorder (OUD) is a substance use disorder characterized by cravings for opioids, continued use despite physical and/or psychological deterioration, increased tolerance with use, and withdrawal symptoms after discontinuing opioids. Opioid withdrawal symptoms include nausea, muscle aches, diarrhea, trouble sleeping, agitation, and a low mood. Addiction and dependence are important components of opioid use disorder.
Irvin Dana Beal is an American social and political activist, best known for his efforts to legalize marijuana and to promote the benefits of Ibogaine as an addiction treatment. He is a founder and long-term activist in the Youth International Party (Yippies), and founded the Yipster Times newspaper in 1972. The Yipster Times was renamed Overthrow in 1978, and ended publication in 1989.
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption of the drug. A drug addiction, a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences. An addictive drug is a drug which is both rewarding and reinforcing. ΔFosB, a gene transcription factor, is now known to be a critical component and common factor in the development of virtually all forms of behavioral and drug addictions, but not dependence.
Howard Lotsof was an American scientific researcher who discovered and pioneered the use of ibogaine as an approach in Western medicine in the treatment of substance addictions. In 1962, at the age of 19, Lotsof was addicted to heroin and accidentally discovered the anti-addictive effects of ibogaine. He later attended Fairleigh Dickinson University and then New York University, graduating with a degree in film in 1976.
Ibogaine is a naturally occurring psychoactive substance found in plants in the family Apocynaceae such as Tabernanthe iboga, Voacanga africana, and Tabernaemontana undulata. It is a psychedelic with dissociative properties.
Organic brain syndrome, also known as organic brain disease, organic brain damage, organic brain disorder, organic mental syndrome, or organic mental disorder, refers to any syndrome or disorder of mental function whose cause is alleged to be known as organic (physiologic) rather than purely of the mind. These names are older and nearly obsolete general terms from psychiatry, referring to many physical disorders that cause impaired mental function. They are meant to exclude psychiatric disorders. Originally, the term was created to distinguish physical causes of mental impairment from psychiatric disorders, but during the era when this distinction was drawn, not enough was known about brain science for this cause-based classification to be more than educated guesswork labeled with misplaced certainty, which is why it has been deemphasized in current medicine. While mental or behavioural abnormalities related to the dysfunction can be permanent, treating the disease early may prevent permanent damage in addition to fully restoring mental functions. An organic cause to brain dysfunction is suspected when there is no indication of a clearly defined psychiatric or "inorganic" cause, such as a mood disorder.
18-Methoxycoronaridine, also known as zolunicant, is a derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley D. Glick from the Albany Medical College and the chemists Upul K. Bandarage and Martin E. Kuehne from the University of Vermont. In animal studies it has proved to be effective at reducing self-administration of morphine, cocaine, methamphetamine, nicotine and sucrose. It has also been shown to produce anorectic effects in obese rats, most likely due to the same actions on the reward system which underlie its anti-addictive effects against drug addiction.
Marc Galanter is Professor of Psychiatry at New York University School of Medicine and has served as the Founding Director of the Division of Alcoholism and Drug Abuse. His studies have addressed family therapy for substance abuse, pharmacologic treatment for addiction, and Twelve Step recovery for addiction. He is an author of over 200 peer-reviewed articles. He chairs Twelve Step Interest Groups in AAAP, ASAM, and the International Society of Addiction Medicine and teaches at the New York University School of Medicine.
Addiction medicine is a medical subspecialty that deals with the diagnosis, prevention, evaluation, treatment, and recovery of persons with addiction, of those with substance-related and addictive disorders, and of people who show unhealthy use of substances including alcohol, nicotine, prescription medicine and other illicit and licit drugs. The medical subspecialty often crosses over into other areas, since various aspects of addiction fall within the fields of public health, psychology, social work, mental health counseling, psychiatry, and internal medicine, among others. Incorporated within the specialty are the processes of detoxification, rehabilitation, harm reduction, abstinence-based treatment, individual and group therapies, oversight of halfway houses, treatment of withdrawal-related symptoms, acute intervention, and long term therapies designed to reduce likelihood of relapse. Some specialists, primarily those who also have expertise in family medicine or internal medicine, also provide treatment for disease states commonly associated with substance use, such as hepatitis and HIV infection.
Excited delirium (ExDS), also known as agitated delirium (AgDS) or hyperactive delirium syndrome with severe agitation, is a widely rejected diagnosis characterized as a potentially fatal state of extreme agitation and delirium. It has typically been diagnosed postmortem in young adult black males who were physically restrained by law enforcement personnel at the time of death.
Cocaine dependence is a neurological disorder that is characterized by withdrawal symptoms upon cessation from cocaine use. It also often coincides with cocaine addiction which is a biopsychosocial disorder characterized by persistent use of cocaine and/or crack despite substantial harm and adverse consequences. The Diagnostic and Statistical Manual of Mental Disorders, classifies problematic cocaine use as a stimulant use disorder. The International Classification of Diseases, includes "Cocaine dependence" as a classification (diagnosis) under "Disorders due to use of cocaine".
Behavioral addiction, process addiction, or non-substance-related disorder is a form of addiction that involves a compulsion to engage in a rewarding non-substance-related behavior – sometimes called a natural reward – despite any negative consequences to the person's physical, mental, social or financial well-being. In the brain's reward system, a gene transcription factor known as ΔFosB has been identified as a necessary common factor involved in both behavioral and drug addictions, which are associated with the same set of neural adaptations.
Robert L. DuPont is an American psychiatrist, known for his advocacy in the field of substance abuse. He is president of the Institute for Behavior and Health, whose mission is "to reduce the use of illegal drugs". He has written books including Chemical Slavery: Understanding Addiction and Stopping the Drug Epidemic,The Selfish Brain: Learning from Addiction, as well as Drug Testing in Treatment Settings, Drug Testing in Schools, and Drug Testing in Correctional Settings, published by the Hazelden Foundation. DuPont is a fellow of the American Society of Addiction Medicine and a life fellow of the American Psychiatric Association.
Substance use disorder (SUD) is the persistent use of drugs despite the substantial harm and adverse consequences to one's own self and others, as a result of their use. In perspective, the effects of the wrong use of substances that are capable of causing harm to the user or others, have been extensively described in different studies using a variety of terms such as substance use problems, problematic drugs or alcohol use, and substance use disorder. The National Institute of Mental Health (NIMH) states that "Substance use disorder (SUD) is a treatable mental disorder that affects a person's brain and behavior, leading to their inability to control their use of substances like legal or illegal drugs, alcohol, or medications. Symptoms can be moderate to severe, with addiction being the most severe form of SUD". Substance use disorders (SUD) are considered to be a serious mental illness that fluctuates with the age that symptoms first start appearing in an individual, the time during which it exists and the type of substance that is used. It is not uncommon for those who have SUD to also have other mental health disorders. Substance use disorders are characterized by an array of mental/emotional, physical, and behavioral problems such as chronic guilt; an inability to reduce or stop consuming the substance(s) despite repeated attempts; operating vehicles while intoxicated; and physiological withdrawal symptoms. Drug classes that are commonly involved in SUD include: alcohol (alcoholism); cannabis; opioids; stimulants such as nicotine, cocaine and amphetamines; benzodiazepines; barbiturates; and other substances.
Patrick Karel Kroupa known colloquially as Lord Digital is an American writer, hacker and activist. Kroupa was a member of the Legion of Doom and Cult of the Dead Cow hacker groups and co-founded MindVox in 1991, with Bruce Fancher.
Bell's mania, also known as delirious mania, refers to an acute neurobehavioral syndrome. This is usually characterized by an expeditious onset of delirium, mania, psychosis, followed by grandiosity, emotional lability, altered consciousness, hyperthermia, and in extreme cases, death. It is sometimes misdiagnosed as excited delirium (EXD) or catatonia due to the presence of overlapping symptoms. Pathophysiology studies reveal elevated dopamine levels in the neural circuit as the underlying mechanism. Psychostimulant users as well as individuals experiencing severe manic episodes are more prone to the manifestation of this condition. Management solutions such as sedation and ketamine injections have been discussed for medical professionals and individuals with the condition. Bell's mania cases are commonly reported in countries like the United States and Canada and are commonly associated with psychostimulant use and abuse.
Ayana Jordan is an American addiction psychiatrist and immunopathologist. She researches treatments for substance use disorders in marginalized communities. She is the Barbara Wilson Associate Professor of Psychiatry at NYU Langone Health and was a professor at Yale School of Medicine. She served as an attending psychiatrist in the Yale University Department of Psychiatry. She was elected to the Board of Trustees of the American Psychiatric Association in 2018. She attended Hampton University and received her MD and PhD from the Albert Einstein College of Medicine.
References
- 1 2 3 Mash, Deborah. "Interesting People: Dr. Deborah Mash" (Interview). The Herbert W. Hoover Foundation. Retrieved November 23, 2017.
- 1 2 3 "Deborah Mash". uhealthsystem.com. University of Miami Health System. Retrieved November 23, 2017.
- ↑ Price, Stephanie (June 12, 2020). "Could ibogaine offer a revolutionary long-term solution to addiction?". Health Europa. Retrieved March 11, 2021.
- 1 2 "Uncovering Ibogaine: The Deborah Mash Interview". Let Them Talk (Interview). Interviewed by Paul De Rienzo. New York. July 1996. Archived from the original on March 11, 2016. Retrieved November 23, 2017.
- 1 2 "Ibogaine: Treatment Outcomes and Observations" (PDF). 13 (2). Multidisciplinary Association for Psychedelic Studies. 2003: 16. Retrieved November 23, 2017.
{{cite journal}}: Cite journal requires|journal=(help) - ↑ Obembe, Samuel B. (2012). Practical Skills and Clinical Management of Alcoholism and Drug Addiction. Elsevier. p. 90. ISBN 978-0-12-398518-7 . Retrieved November 23, 2017.
- ↑ Mash, Deborah (May 3, 2010). "Clean, Ibogaine Clean". The Gnostic Media Podcast (Interview). Interviewed by Jan Irvin. Gnostic Media.
- ↑ Humberto, Fernandez; Libby, Therissa A. (May 17, 2011). Heroin: Its History, Pharmacology & Treatment. Simon and Schuster. ISBN 978-1-59285-990-0 . Retrieved November 23, 2017.
- ↑ Szep, Jason; Reid, Tim; Eisler, Peter (August 24, 2017). "How Taser inserts itself into investigations involving its own weapons". Reuters Investigates. Reuters . Retrieved November 23, 2017.
- 1 2 Miletich, John J.; Lindstrom, Tia Laura (2010). An Introduction to the Work of a Medical Examiner: From Death Scene to Autopsy Suite. Praeger. p. 32. ISBN 9780275995089 . Retrieved November 23, 2017.
- ↑ Position Statement on Concerns About Use of the Term "Excited Delirium" and Appropriate Medical Management in Out-of-Hospital Contexts (PDF) (Report). American Psychiatric Association. November 2020. Retrieved December 28, 2021.
- ↑ Vilke GM, Payne-James JJ (2016). Current Practice in Forensic Medicine. John Wiley & Sons, Ltd. pp. 97–117. doi:10.1002/9781118456026.ch6. ISBN 9781118456026.
