Dimetridazole

Last updated
Dimetridazole
Dimetridazole structure.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATCvet code
Identifiers
  • 1,2-dimethyl-5-nitro-1H-imidazole
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.008.184 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C5H7N3O2
Molar mass 141.130 g·mol−1
3D model (JSmol)
  • Cc1ncc([N](=O)=O)n1C
  • InChI=1S/C5H7N3O2/c1-4-6-3-5(7(4)2)8(9)10/h3H,1-2H3 Yes check.svgY
  • Key:IBXPYPUJPLLOIN-UHFFFAOYSA-N Yes check.svgY
   (verify)

Dimetridazole is a drug that combats protozoan infections. It is a nitroimidazole class drug. [1] It used to be commonly added to poultry feed. This led to it being found in eggs. Because of suspicions of it being carcinogenic its use has been legally limited but it is still found in the eggs. [2] [3] It is now banned as a livestock feed additive in many jurisdictions, for example in the European Union, [4] Canada. [5] and the United States. [6] In the US, the Food and Drug Administration bans it for extralabel use [7]

See also

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References

  1. Dalton, P. (1996). "Use of dimetridazole in gamebirds". The Veterinary Record. 139 (16): 399. PMID   8913016.
  2. Posyniak A, Semeniuk S, Zmudzki J, Niedzielska J, Biernacki B (1996). "Residues of dimetridazole in eggs after treatment of laying hens". Veterinary Research Communications. 20 (2): 167–74. doi:10.1007/bf00385638. PMID   8711897. S2CID   38729121.
  3. Cannavan A, Kennedy DG (1997). "Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry". The Analyst. 122 (9): 963–6. Bibcode:1997Ana...122..963C. doi:10.1039/a703193i. PMID   9374025.
  4. Council Regulation (EEC) No 2377/90 of 26 June 1990
  5. Canadian Food Inspection Agency update Archived May 7, 2005, at the Wayback Machine
  6. US Food and Drugs Administration, Food Additives Status List
  7. US Food and Drug Administration, Code of Federal Regulations, Title 21, Volume 6, Revised as of April 1, 2020