Dinitolmide

Last updated
Dinitolmide
Zoalene.png
Names
Preferred IUPAC name
2-Methyl-3,5-dinitrobenzamide
Other names
3,5-Dinitro-o-toluamide
Zoalene
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.005.189 OOjs UI icon edit-ltr-progressive.svg
PubChem CID
UNII
  • InChI=1S/C8H7N3O5/c1-4-6(8(9)12)2-5(10(13)14)3-7(4)11(15)16/h2-3H,1H3,(H2,9,12) Yes check.svgY
    Key: ZEFNOZRLAWVAQF-UHFFFAOYSA-N Yes check.svgY
  • InChI=1/C8H7N3O5/c1-4-6(8(9)12)2-5(10(13)14)3-7(4)11(15)16/h2-3H,1H3,(H2,9,12)
    Key: ZEFNOZRLAWVAQF-UHFFFAOYAL
  • O=[N+]([O-])c1cc(cc(C(=O)N)c1C)[N+]([O-])=O
Properties
C8H7N3O5
Molar mass 225.16 g/mol
Melting point 177 °C; 351 °F; 450 K [1]
Pharmacology
QP51AX12 ( WHO )
Hazards
Flash point noncombustible [1]
NIOSH (US health exposure limits):
PEL (Permissible)
none [1]
REL (Recommended)
TWA 5 mg/m3 [1]
IDLH (Immediate danger)
N.D. [1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Dinitolmide (or zoalene) is a fodder additive for poultry, used to prevent coccidiosis infections. [2] It is sold under trade names such as Coccidine A, Coccidot, and Zoamix.

Dinitolmide is usually added to feed in doses of 125 ppm (preventive) or 250 ppm (curative). It is a broad-spectrum anticoccidial drug, [2] preventing seven main strains of Eimeria coccidium . It leaves no residues in tissues.[ citation needed ] It can be also used to prevent coccidiosis of domestic rabbits.

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Eimeria arlongi is a species of Eimeria that causes clinical coccidiosis in goats. It and Eimeria ninakohlyakimovae are two of the most pathogenic species for goats. It is particularly prevalent in goat kids in Iran. Issues with coccidiosis specifically due to Eimeria arloingi have also been reported in Egypt and Portugal. It is unclear whether this species is present in the Americas as most of the case reports of coccidiosis in these areas do not differentiate the species causing the disease. Infections with this species are commonly compounded by infections with other Eimeria species in "mixed infections." This species is closely related to Eimeria bovis and Eimeria zuernii which are both highly pathogenic in cattle' Infections with this species are characterized by lesions specifically in the jejunum, but also the ilium and cecum which results in diarrhea. Oocysts begin shedding between 16 and 18 days after the animal is infected which is when the parasite is spread. The shedding can last as long as 15 days. This parasite causes an immune response in its host that includes accumulation of fluid in body cavities, presence of large numbers of leukocytes in the small intestine, and necrosis of the tissue of the small intestine. Pale yellow plaques can be seen on the small intestine of severely affected kids at necropsy.

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References

  1. 1 2 3 4 5 NIOSH Pocket Guide to Chemical Hazards. "#0230". National Institute for Occupational Safety and Health (NIOSH).
  2. 1 2 Gerhold, R. W.; Fuller, A. L.; Lollis, L.; Parr, C.; McDougald, L. R. (2011). "The Efficacy of Anticoccidial Products against Eimeria spp. in Northern Bobwhites". Avian Diseases. 55 (1): 59–64. doi:10.1637/9572-101310-Reg.1. PMID   21500637. S2CID   30943649.