Dolosigranulum pigrum

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Dolosigranulum pigrum
Scientific classification
Domain:
Bacteria
Phylum:
Bacillota
Class:
Bacilli
Order:
Lactobacillales
Family:
Carnobacteriaceae
Genus:
Dolosigranulum
Species:
D. pigrum
Binomial name
Dolosigranulum pigrum
Aguirre et al. 1994 [1]
Type strain
ATCC 51524, CCUG 33392, CIP 104051, IFO 15550, LMG 15126, NBRC 15550, NCFB 2975, NCIMB 702975, R91/1468 [2]

Dolosigranulum pigrum is a Gram-positive bacterium from the genus of Dolosigranulum. [1] [2] [3] Dolosigranulum pigrum can cause infections in the upper respiratory tract, as well as nosocomial pneumonia and sepsis. [4] [5] [6] The metabolism of this organism has been reconstructed. It is available as a genome-scale metabolic model, which indicates incomplete biochemical pathways within the central carbon metabolism. [7] Consequently, its metabolism depends on other members of its microbial habitat, such as Staphylococcus aureus , whose growth D. pigrum negatively impacts. [8]

D. pigrum is highly adapted to the human nasal passages. In an analysis of 8,184 samples from six human body sites, Dolosigranulum sequencing reads were identified in 41% of nasal samples, 15% of skin samples, and less than 1% of fecal and oral cavity samples. Moreover, in samples in which Dolosigranulum was detected, the organism was far more abundant in nasal samples (18% mean relative abundance) than in samples from other body sites (less than 2% mean relative abundance). Analyses of data from the Earth Microbiome Project revealed that Dolosigranulum reads were rarely identified in environmental sources (e.g., water, soil) but were found in samples from a variety of animal species, including rodents, fish, birds, dogs, and primates. [9]

References

  1. 1 2 Parte, A.C. "Dolosigranulum". LPSN .
  2. 1 2 "Dolosigranulum pigrum". www.uniprot.org.
  3. ↑ Stephen, Dr. Berger (2015). GIDEON Guide to Medically Important Bacteria. GIDEON Informatics Inc. ISBN   978-1-4988-0429-5.
  4. ↑ "Dolosigranulum pigrum ATCC 51524 (ID 67783) - BioProject - NCBI". www.ncbi.nlm.nih.gov.
  5. ↑ Laclaire, L.; Facklam, R. (1 July 2000). "Antimicrobial Susceptibility and Clinical Sources of Dolosigranulum pigrum Cultures". Antimicrobial Agents and Chemotherapy. 44 (7): 2001–2003. doi:10.1128/AAC.44.7.2001-2003.2000. PMC   90003 . PMID   10858372.
  6. ↑ Lecuyer, H.; Audibert, J.; Bobigny, A.; Eckert, C.; Janniere-Nartey, C.; Buu-Hoi, A.; Mainardi, J.-L.; Podglajen, I. (8 August 2007). "Dolosigranulum pigrum Causing Nosocomial Pneumonia and Septicemia". Journal of Clinical Microbiology. 45 (10): 3474–3475. doi:10.1128/JCM.01373-07. PMC   2045320 . PMID   17687015.
  7. ↑ Renz, Alina; Widerspick, Lina; Dräger, Andreas (2021). "First Genome-Scale Metabolic Model of Dolosigranulum pigrum Confirms Multiple Auxotrophies". Metabolites. 11 (4): 232. doi: 10.3390/metabo11040232 . PMC   8069353 . PMID   33918864.
  8. ↑ Mostolizadeh, Reihaneh; Glöckler, Manuel; Dräger, Andreas (2022). "Towards the human nasal microbiome: simulating D. pigrum and S. aureus". Frontiers in Cellular and Infection Microbiology. 12. doi: 10.3389/fcimb.2022.925215 . PMC   9810029 . PMID   36605126.
  9. ↑ Stubbendieck, Reed M.; Hurst, Jillian H.; Kelly, Matthew S. (1 February 2024). "Dolosigranulum pigrum: A promising nasal probiotic candidate". PLOS Pathogens. 20 (2): e1011955. doi: 10.1371/journal.ppat.1011955 . ISSN   1553-7374. PMC   10833571 . Creative Commons by small.svg  This article incorporates textfrom this source, which is available under the CC BY 4.0 license.


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