Dunedin Multidisciplinary Health and Development Study

Last updated

The Dunedin Multidisciplinary Health and Development Study (also known as the Dunedin Study) is a detailed study of human health, development and behaviour. Based at the University of Otago in New Zealand, the Dunedin Study has followed the lives of 1037 babies born between 1 April 1972 and 31 March 1973 at Dunedin's former Queen Mary Maternity Centre since their birth. Teams of national and international collaborators work on the Dunedin Study, including a team at Duke University in the United States. The research is constantly evolving to encompass research made possible by new technology and seeks to answer questions about how people's early years have an impact on mental and physical health as they age.[ citation needed ]

Contents

The study is now in its fifth decade and has produced over 1300 publications and reports, many of which have influenced or helped inform policy makers in New Zealand and overseas; many of these can be found on the publications section of their website.[ citation needed ]

History

The Dunedin Study was the idea of psychology student Phil Silva, who worked on a neonatology survey involving 250 children with learning and behavioural issues. He identified that 10% had significant problems that had previously been undiagnosed, a topic that he researched in his 1978 doctoral thesis. [1] He realised that a larger sample size was needed; this resulted in the Dunedin Study. [2] The original pool of study members was selected from children born at the Queen Mary Maternity Centre in Dunedin who were still living in the wider Otago region three years later. In early years the study was not well funded and the local community helped collect data. [3] The study members include 535 males and 502 females, 1013 singletons and 12 sets of twins. At the age 38 assessment, only one-third of members still resided in Dunedin; most of the remainder lived elsewhere in New Zealand and Australia. [4] Study members were assessed at age three, and then at ages 5, 7, 9, 11, 13, 15, 18, 21, 26, 32, 38 and, most recently, at age 45 (2017–2019). Future assessments are scheduled for age 52. [5] Silva directed the study until he retired from the role in 2000. [2] Professor Richie Poulton was the study's director from 2000 to 2023, [6] and was succeeded by Associate Professor Moana Theodore. [7] She first worked for the study as an assistant in 1998, and returned in 2010 to work with Poulton. [8]

During an assessment, study members are brought back to Dunedin from wherever in the world they live. They participate in a day of interviews, physical tests, dental examinations, blood tests, computer questionnaires, and surveys. Sub-studies of the Dunedin Study include the Family Health History Study which involved the parents of Dunedin Study members to find out about the health of family members (2003–2006); the ongoing Parenting Study which focuses on the Dunedin Study member and their first three-year-old child; and the Next Generation Study which involves the offspring of Dunedin Study members as they turn 15 and looks at the lifestyles, behaviours, attitudes, and health of today's teenagers. It aims to see how these have changed from when the original Study Members were 15 (in 1987–88). This means that information across three generations of the same families will be available. [9]

Great emphasis is placed on retention of study members. At the most recent (age 45) assessments, 94% of all living eligible study members, or 961 people, participated. This is unprecedented for a longitudinal study, with many others worldwide experiencing more than 40% drop-out rates. [10]

The resulting database has produced a wealth of information on many aspects of human health and development. As of 2015 over 1,200 papers, reports, book chapters and other publications have been produced using findings from the study. [2] [3] The multidisciplinary aspect of the study has always been a central focus, with information ranging across:[ citation needed ]

A book, From Child to Adult: Dunedin Multidisciplinary Health and Development Study, was published in 1996 and aimed at presenting the major findings in a form accessible to the non-specialist. It only includes information up to the age-21 assessment. Future plans for the Dunedin Multidisciplinary Health and Development Study include another popular science book, upgrading their website for more non-specialist appeal, and introducing more resources for the general public. [11]

This study was awarded the 2016 Prime Minister's Science Prize. [12] In 2022 it was awarded the Royal Society Te Apārangi's Rutherford Medal. [13]

Findings

The Dunedin Study has found that walking speed is related to small brain differences, that the speed of ageing of one's brain relates to their general speed of ageing, a link between the amount of white matter hyperintensities and a person's rate of cognitive decline, that there are differences in brain structure of people with and without antisocial behaviour in their teenage/young adult years, a link between IQ and brain size; the correspondence of brain structure with poor mental state, cardiovascular fitness, lead exposure, difficult childhoods, childhood self-control, and cannabis use. [14] They have also found that children experiencing social isolation between the ages of 5 and 11 were more likely to have poor cardiovascular health, and increased age-related cognitive decline compared to those who were not socially isolated. [15]

The Dunedin Study has also suggested that poor mental health can cause poor physical health, and increased rates of ageing. [16]

See also

Related Research Articles

<span class="mw-page-title-main">Acrophobia</span> Extreme fear of heights

Acrophobia is an extreme or irrational fear or phobia of heights, especially when one is not particularly high up. It belongs to a category of specific phobias, called space and motion discomfort, that share similar causes and options for treatment.

<span class="mw-page-title-main">Rutherford Medal (Royal Society of New Zealand)</span> Award of the Royal Society of New Zealand

The Rutherford Medal is the most prestigious award offered by the Royal Society of New Zealand, consisting of a medal and prize of $100,000. It is awarded at the request of the New Zealand Government to recognize exceptional contributions to the advancement and promotion of public awareness, knowledge and understanding in addition to eminent research or technological practice by a person or group in any field of science, mathematics, social science, or technology. It is funded by the New Zealand government and awarded annually.

Sir Albert William Liley was a New Zealand medical practitioner, renowned for developing techniques to improve the health of foetuses in utero.

Psychiatric epidemiology is a field which studies the causes (etiology) of mental disorders in society, as well as conceptualization and prevalence of mental illness. It is a subfield of the more general epidemiology. It has roots in sociological studies of the early 20th century. However, while sociological exposures are still widely studied in psychiatric epidemiology, the field has since expanded to the study of a wide area of environmental risk factors, such as major life events, as well as genetic exposures. Increasingly neuroscientific techniques like MRI are used to explore the mechanisms behind how exposures to risk factors may impact psychological problems and explore the neuroanatomical substrate underlying psychiatric disorders.

Lawrence J. Whalley MB, BS, MD, DPM, FRCP(E), FRC Psych was formerly the Crombie Ross Professor of Mental Health in the University of Aberdeen, Scotland, UK from 1992 to 2008. He remains professor emeritus at the University of Aberdeen and from 2010-2020 part-time professor of research at the University of the Highlands and Islands.

Accident-proneness is the idea that some people have a greater predisposition than others to experience accidents, such as car crashes and industrial injuries. It may be used as a reason to deny any insurance on such individuals.

David Murray Fergusson was a New Zealand psychologist. He was a professor of psychological medicine at the University of Otago, Christchurch, from 1999 until 2015. He is notable for work on the Christchurch Health and Development Study and for his research on abortion and mental health.

The fear of falling (FOF), also referred to as basophobia, is a natural fear and is typical of most humans and mammals, in varying degrees of extremity. It differs from acrophobia, although the two fears are closely related. The fear of falling encompasses the anxieties accompanying the sensation and the possibly dangerous effects of falling, as opposed to the heights themselves. Those who have little fear of falling may be said to have a head for heights. Basophobia is sometimes associated with astasia-abasia, the fear of walking/standing erect.

Terrie Edith Moffitt is an American-British clinical psychologist who is best known for her pioneering research on the development of antisocial behavior and for her collaboration with colleague and partner Avshalom Caspi in research on gene-environment interactions in mental disorders.

Why Am I?: The Science of Us is a 2016 New Zealand documentary series about the Dunedin Multidisciplinary Health and Development Study, a long-running cohort study following 1037 people born in Dunedin, New Zealand during 1972 and 1973. The study revealed the result of the combined effects of hereditary (genes) and environment (upbringing) on how people turn out.

The University of Sydney's Brain and Mind Centre was established for the research and treatment of disorders of the brain and mind.

Avshalom Caspi is an Israeli-American psychologist and the Edward M. Arnett Professor of Psychology and Neuroscience in the Trinity College of Arts and Sciences at Duke University, as well as Professor of Personality Development at King's College London's Institute of Psychiatry, Psychology and Neuroscience. He is known for his research on mental health and human development, much of which he has conducted with his wife and longtime research partner, Terrie Moffitt. The two first met when they presented adjacent posters at a 1987 conference in St. Louis, Missouri entitled "Deviant Pathways from Childhood to Adulthood". Among Caspi's notable discoveries was that of an association between the 5-HTTLPR polymorphism and clinical depression. This discovery, originally reported in a 2003 study, spurred a wave of subsequent research on the potential genetic roots of various psychiatric conditions. However, a 2017 meta-analysis did not support the original finding, nor did a large analysis with nearly 100% power to detect the original finding. Therefore, the general approach of candidate gene or candidate gene by environment interaction research in single small studies is no longer widely accepted.

Adverse childhood experiences (ACEs) include childhood emotional, physical, or sexual abuse and household dysfunction during childhood. The categories are verbal abuse, physical abuse, contact sexual abuse, a battered mother, household substance abuse, household mental illness, incarcerated household members, and parental separation or divorce. The experiences chosen were based upon prior research that has shown to them to have significant negative health or social implications, and for which substantial efforts are being made in the public and private sector to reduce their frequency of occurrence. Scientific evidence is mounting that such adverse childhood experiences (ACEs) have a profound long-term effect on health. Research shows that exposure to abuse and to serious forms of family dysfunction in the childhood family environment are likely to activate the stress response, thus potentially disrupting the developing nervous, immune, and metabolic systems of children. ACEs are associated with lifelong physical and mental health problems that emerge in adolescence and persist into adulthood, including cardiovascular disease, chronic obstructive pulmonary disease, autoimmune diseases, substance abuse, and depression.

<span class="mw-page-title-main">Richie Poulton</span> New Zealand psychologist (1962–2023)

Richie Graham Poulton was a New Zealand psychologist and the director of the University of Otago's Dunedin Multidisciplinary Health & Development Research Unit, which runs the Dunedin Multidisciplinary Health and Development Study. He was also a professor of psychology at the University of Otago, the 2007 founder and co-director of the National Centre for Lifecourse Research, the founder in 2011 of the Graduate Longitudinal Study, New Zealand, and the chief science adviser of the Ministry of Social Development in the New Zealand government.

<span class="mw-page-title-main">Jim Mann (scientist)</span> New Zealand nutritionist and endocrinologist

Sir Joel Ivor Mann, generally known as Jim Mann, is a New Zealand nutritionist and endocrinologist. He is professor in human nutrition and medicine at the University of Otago and consultant physician (endocrinology) at Dunedin Hospital. He has researched the role of lipids and carbohydrates in coronary heart disease, diabetes, and obesity, as well as the relationship between obesity and cancer. He was knighted in the 2022 New Year Honours.

Louise Arseneault is a Canadian psychologist and Professor of Developmental Psychology in the Social, Genetic & Developmental Psychiatry Centre in the Institute of Psychiatry, Psychology and Neuroscience at King's College London, where she has taught since 2001.

Betty Margaret Bernardelli was a physiological psychologist at the University of Otago in New Zealand. With an MA from Cambridge University, Bernardelli was the commanding officer at the WAAF training school for psychology instructors. After the war, Bernardelli worked in a team advising demobilised air force personnel on their future employment prospects, and set up a testing unit for the Royal Navy. Bernardelli was also part of a research team in Cambridge, focusing on about how best to assist men and women aged 35–40 forced to change their occupation.

Anne Briar Smith was a New Zealand professor at the University of Otago, and was a pioneering children's rights researcher.

<span class="mw-page-title-main">Moana Theodore</span> New Zealand epidemiologist

Reremoana Farquharson Theodore is a New Zealand epidemiologist specialising in longitudinal research in Māori health and education. She is the director of the Dunedin Multidisciplinary Health and Development Study and was director of the University of Otago's National Centre for Lifecourse Research in Dunedin.

<span class="mw-page-title-main">Ageing Well</span> Collaborative public health research programme in New Zealand (2015–2024)

Ageing Well is one of New Zealand's eleven collaborative research programmes known as National Science Challenges. Running from 2015 to 2024, the focus of Ageing Well National Science Challenge (AWNSC) research is sustaining health and wellbeing towards the end of life, particularly in Māori and Pacific populations in New Zealand.

References

  1. Silba, Phil A. "Some neurological and psychological characteristics of children who were preterm and small for gestational age : a multi-disciplinary study" . Retrieved 18 October 2022.
  2. 1 2 3 Matthews, Philip (16 June 2016). "National portrait: Phil Silva, psychology pioneer". Stuff . Retrieved 10 October 2021.
  3. 1 2 Poulton, Richie; Moffitt, Terrie E.; Silva, Phil (2015). "The Dunedin Multidisciplinary Health and Development Study: overview of the first 40 years, with an eye to the future". Social Psychiatry and Psychiatric Epidemiology. 50 (5): 679–693. doi:10.1007/s00127-015-1048-8. ISSN   0933-7954. PMC   4412685 . PMID   25835958.
  4. "The Study Members". Dunedin Multidisciplinary Health & Development Research Unit. Retrieved 13 March 2016.
  5. "Dunedin Study published information". Dunedin Study. Archived from the original on 12 October 2014.
  6. Chisholm, Donna (February 2017). "Finding the key to successful ageing". North & South (371): 36–49. Archived from the original on 4 July 2017. Retrieved 10 July 2017.
  7. "New Dunedin Study director named". Stuff. 24 October 2023. Retrieved 24 October 2023.
  8. "New Dunedin Study director announced after Richie Poulton's death". 1 News. Retrieved 25 October 2023.
  9. Hancox, Bob. "Next Generation Study". Dunedin Multidisciplinary Health & Research Unit. Dunedin Multidisciplinary Health and Development Study. Retrieved 18 October 2022.
  10. Roberts, Brent; Walton, Kate; Viechtbauer, Wolfgang (2006). "Patterns of mean-level change in personality traits across the life course: A meta-analysis of longitudinal studies". Psychological Bulletin. 132 (1): 1–25. doi:10.1037/0033-2909.132.1.1. PMID   16435954. S2CID   16606495 . Retrieved 18 October 2022.
  11. Silva, Phil A.; Stanton, Warren R., eds. (1996). From child to adult : the Dunedin multidisciplinary health and development study. Auckland: Oxford University Press. ISBN   0195583604. Archived from the original on 1 October 2023. Retrieved 1 October 2023.
  12. "2016 Prime Minister's Science Prize Winner | The Prime Minister's Science Prizes". www.pmscienceprizes.org.nz. Retrieved 6 August 2017.
  13. "The Dunedin Study wins Rutherford Medal and other Research Honours Aotearoa winners celebrated in Ōtepoti Dunedin". Royal Society Te Apārangi. Retrieved 16 November 2022.
  14. "What are our main findings so far? | The Dunedin Study – Dunedin Multidisciplinary Health & Development Research Unit". dunedinstudy.otago.ac.nz. Retrieved 7 October 2023.
  15. "Dunedin Study Evidence Summary Submission to the Royal Commission into Early Childhood Education and Care" (PDF). Royal Commission into Early Childhood Education and Care . Retrieved 8 October 2023.
  16. "Dunedin Study data provides evidence that youth mental health issues impact adult physical health". New Zealand Doctor. 5 November 2023. Retrieved 7 October 2023.