EIF4EBP2

EIF4EBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MX4, 3AM7
Identifiers
Aliases	EIF4EBP2 , 4EBP2, PHASII, eukaryotic translation initiation factor 4E binding protein 2
External IDs	OMIM: 602224; MGI: 109198; HomoloGene: 3022; GeneCards: EIF4EBP2; OMA:EIF4EBP2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q22.1 Start 70,404,145 bp [1] End 70,428,618 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 B4|10 32.21 cM Start 61,264,270 bp [2] End 61,288,440 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell internal globus pallidus parotid gland epithelium of colon amniotic fluid jejunal mucosa ganglionic eminence palpebral conjunctiva mucosa of ileum tendon of biceps brachii Top expressed in extensor digitorum longus muscle lactiferous gland tail of embryo genital tubercle plantaris muscle gallbladder Ileal epithelium superior surface of tongue transitional epithelium of urinary bladder yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding eukaryotic initiation factor 4E binding translation repressor activity translation initiation factor activity Cellular component cytoplasm postsynapse intracellular anatomical structure Biological process social behavior insulin receptor signaling pathway modulation of chemical synaptic transmission negative regulation of translation memory TOR signaling protein biosynthesis cAMP-mediated signaling regulation of translation negative regulation of translational initiation regulation of synaptic plasticity translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1979 13688 Ensembl ENSG00000148730 ENSMUSG00000020091 UniProt Q13542 P70445 RefSeq (mRNA) NM_004096 NM_010124 RefSeq (protein) NP_004087 NP_004087.1 NP_034254 Location (UCSC) Chr 10: 70.4 – 70.43 Mb Chr 10: 61.26 – 61.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene. ^{[5] [6] [7]}

Animal studies

EIF4EBP2 knockout mice have been used as an animal model of autism. Mice without the Eif4ebp2 gene exhibited autism-like symptoms, including poor social interaction, altered communication and repetitive behaviors. Knockout mice have high levels of Neuroligins. ^[8]

Interactions

EIF4EBP2 has been shown to interact with EIF4E. ^{[5] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000148730 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020091 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N (October 1994). "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function". Nature. 371 (6500): 762–7. Bibcode:1994Natur.371..762P. doi:10.1038/371762a0. PMID   7935836. S2CID   4360955.
6. Tsukiyama-Kohara K, Vidal SM, Gingras AC, Glover TW, Hanash SM, Heng H, Sonenberg N (December 1996). "Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2". Genomics. 38 (3): 353–63. doi:10.1006/geno.1996.0638. PMID   8975712.
7. "Entrez Gene: EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2".
8. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N (January 2013). "Autism-related deficits via dysregulated eIF4E-dependent translational control". Nature. 493 (7432): 371–7. Bibcode:2013Natur.493..371G. doi:10.1038/nature11628. PMC   4133997 . PMID   23172145.
9. Mader S, Lee H, Pause A, Sonenberg N (September 1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins". Molecular and Cellular Biology. 15 (9): 4990–7. doi:10.1128/mcb.15.9.4990. PMC   230746 . PMID   7651417.

Further reading

• Lin TA, Lawrence JC (November 1996). "Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes". The Journal of Biological Chemistry. 271 (47): 30199–204. doi: 10.1074/jbc.271.47.30199 . PMID   8939971.
• Dilling MB, Germain GS, Dudkin L, Jayaraman AL, Zhang X, Harwood FC, Houghton PJ (April 2002). "4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin". The Journal of Biological Chemistry. 277 (16): 13907–17. doi: 10.1074/jbc.M110782200 . PMID   11847216.
• Shenberger JS, Adams MH, Zimmer SG (August 2002). "Oxidant-induced hypertrophy of A549 cells is accompanied by alterations in eukaryotic translation initiation factor 4E and 4E-binding protein-1". American Journal of Respiratory Cell and Molecular Biology. 27 (2): 250–6. doi:10.1165/ajrcmb.27.2.4785. PMID   12151318.
• Ferguson G, Mothe-Satney I, Lawrence JC (November 2003). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E". The Journal of Biological Chemistry. 278 (48): 47459–65. doi: 10.1074/jbc.M307949200 . PMID   14507920.
• Joshi B, Cameron A, Jagus R (June 2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry. 271 (11): 2189–203. doi: 10.1111/j.1432-1033.2004.04149.x . PMID   15153109.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.