ELAV-like protein 3

ELAVL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D8Z, 1D9A, 1FNX
Identifiers
Aliases	ELAVL3 , HUC, HUCL, PLE21, ELAV like neuron-specific RNA binding protein 3, ELAV like RNA binding protein 3
External IDs	OMIM: 603458; MGI: 109157; HomoloGene: 31035; GeneCards: ELAVL3; OMA:ELAVL3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 11,451,326 bp [1] End 11,481,046 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 A3|9 8.07 cM Start 21,926,301 bp [2] End 21,963,319 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve postcentral gyrus entorhinal cortex ventral tegmental area superior vestibular nucleus ganglionic eminence cerebellar cortex paraflocculus of cerebellum cerebellar vermis pons Top expressed in Rostral migratory stream cerebellar cortex lobe of cerebellum cerebellar vermis habenula superior frontal gyrus ganglionic eminence subiculum pontine nuclei medial geniculate nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 1995 15571 Ensembl ENSG00000196361 ENSMUSG00000003410 UniProt Q14576 Q60900 RefSeq (mRNA) NM_001420 NM_032281 NM_010487 RefSeq (protein) NP_001411 NP_115657 NP_034617 Location (UCSC) Chr 19: 11.45 – 11.48 Mb Chr 9: 21.93 – 21.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ELAV-like protein 3 is a protein that in humans is encoded by the ELAVL3 gene. ^{[5] [6]}

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000196361 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003410 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH (Dec 1998). "Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique". Genomics. 53 (3): 296–9. doi:10.1006/geno.1998.5468. PMID   9799595.
6. "Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library". Int. J. Cancer. 100 (6): 669–77. doi:10.1002/ijc.10550. PMID   12209604. S2CID   35369661.
• Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC   85909 . PMID   10848602.
• Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA". Biochem. Biophys. Res. Commun. 256 (2): 263–8. Bibcode:1999BBRC..256..263S. doi:10.1006/bbrc.1999.0282. PMID   10079173.
• Sakai K, Gofuku M, Kitagawa Y, et al. (1994). "A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma". Biochem. Biophys. Res. Commun. 199 (3): 1200–8. Bibcode:1994BBRC..199.1200S. doi:10.1006/bbrc.1994.1358. PMID   7511893.