ERC1

ERC1
Identifiers
Aliases	ERC1 , Cast2, ELKS, ERC-1, RAB6IP2, ELKS/RAB6-interacting/CAST family member 1
External IDs	OMIM: 607127 MGI: 2151013 HomoloGene: 14229 GeneCards: ERC1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	1,495,933 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	119,848,167 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; cerebellar vermis; ; saphenous vein; ; stromal cell of endometrium; ; ganglionic eminence; ; cerebellar hemisphere; ; corpus callosum; ; islet of Langerhans; ; popliteal artery;
	Top expressed in
	cumulus cell; ; stria vascularis; ; cerebellum; ; outer plexiform layer; ; cerebellar cortex; ; yolk sac; ; condyle; ; upper arm; ; cerebellar vermis; ; fossa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	leucine zipper domain binding ; protein binding ; PDZ domain binding ; cadherin binding ;
Cellular component	cytoplasm ; presynaptic active zone ; Golgi membrane ; Golgi apparatus ; synapse ; IkappaB kinase complex ; presynaptic membrane ; membrane ; centrosome ; ciliary basal body ; microtubule organizing center ; cytoskeleton ;
Biological process	multicellular organism development ; protein transport ; retrograde transport, endosome to Golgi ; regulation of transcription, DNA-templated ; I-kappaB phosphorylation ; positive regulation of NF-kappaB transcription factor activity ; negative regulation of apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	23085
	111173
	ENSG00000082805
	ENSMUSG00000030172
	Q8IUD2
	Q99MI1
	NM_001301248 ; NM_178039 ; NM_178040
	NM_053204 ; NM_178085
	NP_001288177 ; NP_829883 ; NP_829884
	NP_444434 ; NP_835186
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 30, 2024

ELKS/RAB6-interacting/CAST family member 1 is a protein that in humans is encoded by the ERC1 gene.^[5]^[6]^[7] The name ELKS is derived from "protein rich in the amino acids E, L, K and S"^[8]

The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene.^[7] ELKS has been reported to direct vesicles with RAB6A to melanosomes.^[8]

Interactions

ERC1 has been shown to interact with RAB6A.^[6]

Related Research Articles

Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is secreted and accumulated at hundreds of grams per litre in the extracellular compartment of the thyroid follicles, accounting for approximately half of the protein content of the thyroid gland. Human TG (hTG) is a homodimer of subunits each containing 2768 amino acids as synthesized.

Midkine, also known as neurite growth-promoting factor 2 (NEGF2), is a protein that in humans is encoded by the MDK gene.

The RETproto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules. RET loss of function mutations are associated with the development of Hirschsprung's disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, pheochromocytoma and parathyroid hyperplasia.

The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or Takeda G protein-coupled receptor 5 (TGR5) as is a protein that in humans is encoded by the GPBAR1 gene.

BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf.

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome. Its main function is the regulation of protein transport from the Golgi complex to the endoplasmic reticulum and the exocytosis along with the microtubules.

NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.

Paired box gene 8, also known as PAX8, is a protein which in humans is encoded by the PAX8 gene.

Kinesin-like protein KIF1B is a protein that in humans is encoded by the KIF1B gene.

Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.

Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene.

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.

Kinesin-like protein KIF20A is a protein that in humans is encoded by the KIF20A gene.

CCAAT/enhancer-binding protein gamma (C/EBPγ) is a protein that in humans is encoded by the CEBPG gene. This gene has no introns.

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.

Proline-rich protein PRCC is a protein that, in humans, is encoded by the PRCC gene.

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.

Protein Niban is a protein that in humans is encoded by the FAM129A gene. Paralogs of this protein include FAM129B, and FAM129C.

High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene.

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000082805 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030172 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yokota T, Nakata T, Minami S, Inazawa J, Emi M (Apr 2000). "Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma". J Hum Genet. 45 (1): 6–11. doi: 10.1007/s100380050002 . PMID 10697956.
1 2 Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (Apr 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic. 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610. S2CID 22993226.
1 2 "Entrez Gene: ERC1 ELKS/RAB6-interacting/CAST family member 1".
1 2 Patwardhan A, Bardin S, Miserey-Lenkei S, Larue L, Goud B, Raposo G, Delevoye C (2017). "Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes". Nature Communications. 8: 15835. Bibcode:2017NatCo...815835P. doi:10.1038/ncomms15835. PMC 5474736 . PMID 28607494.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Armour JA, Crosier M, Jeffreys AJ (1992). "Human minisatellite alleles detectable only after PCR amplification". Genomics. 12 (1): 116–24. doi:10.1016/0888-7543(92)90413-M. PMID 1733848.
Nakata T, Kitamura Y, Shimizu K, et al. (1999). "Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma". Genes Chromosomes Cancer. 25 (2): 97–103. doi:10.1002/(SICI)1098-2264(199906)25:2<97::AID-GCC4>3.0.CO;2-L. PMID 10337992. S2CID 290489.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID 10470851.
Nakata T, Yokota T, Emi M, Minami S (2002). "Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma". Genes Chromosomes Cancer. 35 (1): 30–7. doi:10.1002/gcc.10095. PMID 12203787. S2CID 21891794.
Wang Y, Liu X, Biederer T, Südhof TC (2002). "A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14464–9. Bibcode:2002PNAS...9914464W. doi: 10.1073/pnas.182532999 . PMC 137906 . PMID 12391317.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ko J, Na M, Kim S, et al. (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID 12923177.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Deguchi-Tawarada M, Inoue E, Takao-Rikitsu E, et al. (2004). "CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST". Genes Cells. 9 (1): 15–23. doi: 10.1111/j.1356-9597.2004.00697.x . PMID 14723704. S2CID 13337267.
Ducut Sigala JL, Bottero V, Young DB, et al. (2004). "Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit". Science. 304 (5679): 1963–7. Bibcode:2004Sci...304.1963D. doi:10.1126/science.1098387. PMID 15218148. S2CID 29198955.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000082805 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030172 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10697956-5] Yokota T, Nakata T, Minami S, Inazawa J, Emi M (Apr 2000). "Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma". J Hum Genet. 45 (1): 6–11. doi: 10.1007/s100380050002 . PMID 10697956.

[pmid11929610-6] 1 2 Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (Apr 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic. 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610. S2CID 22993226.

[entrez-7] 1 2 "Entrez Gene: ERC1 ELKS/RAB6-interacting/CAST family member 1".

[pmid28607494-8] 1 2 Patwardhan A, Bardin S, Miserey-Lenkei S, Larue L, Goud B, Raposo G, Delevoye C (2017). "Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes". Nature Communications. 8: 15835. Bibcode:2017NatCo...815835P. doi:10.1038/ncomms15835. PMC 5474736 . PMID 28607494.

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ERC1

Contents

Interactions

Related Research Articles

References

Further reading