EXOC7

EXOC7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PFT
Identifiers
Aliases	EXOC7 , 2-5-3p, EX070, EXO70, EXOC1, Exo70p, YJL085W, exocyst complex component 7, BLOM4, NEDSEBA
External IDs	OMIM: 608163; MGI: 1859270; HomoloGene: 41019; GeneCards: EXOC7; OMA:EXOC7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q25.1 Start 76,081,016 bp [1] End 76,121,576 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E2 Start 116,178,827 bp [2] End 116,198,059 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ganglionic eminence parotid gland ventricular zone right lobe of thyroid gland stromal cell of endometrium external globus pallidus pituitary gland right hemisphere of cerebellum left lobe of thyroid gland Top expressed in triceps brachii muscle spermatocyte spermatid superior frontal gyrus ventricular zone muscle of thigh primary visual cortex temporal muscle neural layer of retina neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm cytosol plasma membrane growth cone membrane exocyst centriolar satellite membrane microtubule organizing center Flemming body Biological process protein transport regulation of entry of bacterium into host cell regulation of macroautophagy exocytosis transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23265 53413 Ensembl ENSG00000182473 ENSMUSG00000020792 UniProt Q9UPT5 O35250 RefSeq (mRNA) NM_001013839 NM_001145297 NM_001145298 NM_001145299 NM_001282313 NM_001282314 NM_015219 NM_001375974 NM_001375975 NM_001375976 NM_001162872 NM_016857 NM_001347636 NM_001362838 NM_001362839 NM_001378960 NM_001378961 RefSeq (protein) NP_001013861 NP_001138769 NP_001138770 NP_001138771 NP_001269242 NP_001269243 NP_056034 NP_001362903 NP_001362904 NP_001362905 NP_001156344 NP_001334565 NP_058553 NP_001349767 NP_001349768 NP_001365889 NP_001365890 Location (UCSC) Chr 17: 76.08 – 76.12 Mb Chr 11: 116.18 – 116.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Exo70 exocyst complex subunit
crystal structure of the s. cerevisiae exocyst component exo70p
Identifiers
Symbol	Exo70
Pfam	PF03081
Pfam clan	CL0295
InterPro	IPR004140
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene. ^{[5] [6]} It was formerly known as Exo70.

It forms one subunit of the exocyst complex. First discovered in Saccharomyces cerevisiae , this and other exocyst proteins have been observed in several other eukaryotes, including humans. ^[7] In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the major site of exocytosis in yeast. ^[7] It interacts with the Rho3 GTPase. ^[8] This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud). ^[9] In humans, the functions of this protein and the exocyst complex are less well characterised: this protein is expressed in several tissues and is thought to also be involved in exocytosis. ^[10]

Interactions

EXOC7 has been shown to interact with EXOC4 ^{[11] [12]} and RHOQ. ^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000182473 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020792 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
6. "Entrez Gene: EXOC7 exocyst complex component 7".
7. TerBush DR, Maurice T, Roth D, Novick P (December 1996). "The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae". EMBO J. 15 (23): 6483–94. doi:10.1002/j.1460-2075.1996.tb01039.x. PMC   452473 . PMID   8978675.
8. Robinson NG, Guo L, Imai J, Toh-E A, Matsui Y, Tamanoi F (May 1999). "Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70". Mol. Cell. Biol. 19 (5): 3580–7. doi:10.1128/MCB.19.5.3580. PMC   84150 . PMID   10207081.
9. Adamo JE, Rossi G, Brennwald P (December 1999). "The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity". Mol. Biol. Cell. 10 (12): 4121–33. doi:10.1091/mbc.10.12.4121. PMC   25747 . PMID   10588647.
10. Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH (December 1997). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. Bibcode:1997PNAS...9414438K. doi: 10.1073/pnas.94.26.14438 . PMC   25013 . PMID   9405631.
11. Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ (Jun 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol. 5 (6): 520–530. doi:10.1038/ncb990. PMID   12738960. S2CID   13444388.
12. Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (Apr 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature . 422 (6932): 629–633. Bibcode:2003Natur.422..629I. doi:10.1038/nature01533. hdl: 2027.42/62982 . PMID   12687004. S2CID   4395760.

Further reading

• Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH (1998). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–14443. Bibcode:1997PNAS...9414438K. doi: 10.1073/pnas.94.26.14438 . PMC   25013 . PMID   9405631.
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID   10470851.
• Soudeyns H, Champagne P, Holloway CL, Silvestri GU, Ringuette N, Samson J, Lapointe N, Sékaly RP (2000). "Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotyping". J. Infect. Dis. 181 (1): 107–120. doi: 10.1086/315181 . PMID   10608757.
• Ignatovich O, Tomlinson IM, Popov AV, Brüggemann M, Winter G (2000). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire". J. Mol. Biol. 294 (2): 457–465. doi:10.1006/jmbi.1999.3243. PMID   10610771.
• Holtmeier W, Hennemann A, Caspary WF (2000). "IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated". Gastroenterology. 119 (5): 1253–1266. doi:10.1053/gast.2000.20219. PMID   11054383.
• Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". J. Biol. Chem. 276 (32): 29792–29797. doi: 10.1074/jbc.C100320200 . PMID   11406615.
• Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. 422 (6932): 629–633. Bibcode:2003Natur.422..629I. doi:10.1038/nature01533. hdl: 2027.42/62982 . PMID   12687004. S2CID   4395760.
• Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–51748. doi: 10.1074/jbc.M308702200 . PMID   14525976.
• Wang S, Liu Y, Adamson CL, Valdez G, Guo W, Hsu SC (2005). "The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization". J. Biol. Chem. 279 (34): 35958–35966. doi: 10.1074/jbc.M313778200 . PMID   15205466.
• Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M (2005). "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2784–2789. Bibcode:2005PNAS..102.2784X. doi: 10.1073/pnas.0409871102 . PMC   549493 . PMID   15705715.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.

This article incorporates text from the public domain Pfam and InterPro: IPR004140